Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model. [PDF]
Front Pharmacol, 2019 Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs) is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases ...
Patutina OA +7 more
europepmc +2 more sources
Site-Specific Cleavage of RNAs Derived from the PIM1 3'-UTR by a Metal-Free Artificial Ribonuclease. [PDF]
Molecules, 2019 Oligonucleotide conjugates of tris(2-aminobenzimidazole) have been reported previously to cleave complementary RNA strands with high levels of sequence and site specificity.
Zellmann F +4 more
europepmc +2 more sources
Rethinking Leucine Zipper : ribonuclease activity and structural dynamics of a ubiquitous oligomerization motif [PDF]
, 2011 This dissertation focuses on structural, dynamic and catalytic properties of a Leucine Zipper (LZ) motif – a family of protein oligomerization domains which belong to the structural class of coiled coil proteins.
Nikolaev, Yaroslav
core +1 more source
Zinc Ion-Dependent Peptide Nucleic Acid-Based Artificial Enzyme that Cleaves RNABulge Size and Sequence Dependence [PDF]
, 2022 In this report, we investigate the efficiency and selectivity of a Zn2+-dependent peptide nucleic acid-based artificial ribonuclease (PNAzyme) that cleaves RNA target sequences. The target RNAs are varied to form different sizes (3 and 4 nucleotides, nt)
Murtola M +3 more
core +2 more sources
Dressing up artificial viral capsids self-assembled from C-terminal-modified beta-annulus peptides [PDF]
A variety of chemical approaches for the rational design of artificial proteins and peptides have been developed in recent years for the construction of self-assembled nanocapsules. It was previously found that a synthetic 24-mer β-annulus peptide, which
Matsuura, Kazunori +5 more
core +2 more sources
Construction of Ribonuclease-Decorated Artificial Virus-like Capsid by Peptide Self-assembly [PDF]
Artificial virus-like capsids decorated with ribonuclease S (RNase S) on their exterior were constructed by the self-assembly of β-annulus-S-peptide and the interaction between S-peptide moiety and S-protein.
Matsuura, Kazunori +17 more
core +1 more source
Too large to fit? Recent developments in macromolecular imprinting. [PDF]
, 2008 Molecular imprinting involves the synthesis of polymers in the presence of a template to produce complementary binding sites with specific recognition ability.
Turner, Anthony P. F. +5 more
core +1 more source
Nano-yarn carbon nanotube fiber based enzymatic glucose biosensor [PDF]
, 2010 This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 IOP Publishing Ltd.A novel brush-like electrode based on carbon nanotube (CNT) nano-yarn fiber has been designed for electrochemical ...
Song, W +5 more
core +1 more source
Construction of Ribonuclease-Decorated Artificial Virus-like Capsid by Peptide Self-assembly
, 2019 Artificial virus-like capsids decorated with ribonuclease S (RNase S) on their exterior were constructed by the self-assembly of β-annulus-S-peptide and the interaction between S-peptide moiety and S-protein.
Junpei Ota (8257518) +4 more
core +1 more source
A novel biological actions acquired by ribonuclease through oligomerization
, 2008 After a short introduction with some examples of cytotoxic ribonucleases, the importance of natural or artificial dimerization (oligomerization) as a way for a ribonuclease to acquire novel functional properties has been pointed out.
LIBONATI, Massimo +2 more
core +1 more source