Results 11 to 20 of about 1,485,663 (260)
Organomercury oligonucleotide conjugates as artificial ribonucleases
Journal of Inorganic Biochemistry, 2023 Two oligonucleotide conjugates sharing the same sequence but incorporating a different 5'-terminal organometallic moiety were synthesized, by either direct mercuration in solution or oximation with an organomercury aldehyde on solid support. The potential of these conjugates to serve as new type of artificial ribonucleases was tested with a ...
Saleh Lange.Y. +2 more
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Development of artificial ribonucleases [PDF]
Pure and Applied Chemistry, 1998 Abstract
Robert Häner +3 more
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Development of Site-specific Artificial Ribonucleases [PDF]
Nucleic Acids Symposium Series, 2007 Recently we found that an antisense 2'-O-methyloligonucleotide, with two terpyridine*Cu(II) complexes at contiguous internal sites, was highly active as a site-specific (sequence-specific) artificial ribonuclease, with the activity derived from the cooperative action of the complexes.
Hiroshi, Takayama +3 more
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Synthesis and Antiviral Activity of Bis-Histidyl Diaminoalkanes in Relation to Feline calicivirus
Антибиотики и Химиотерапия, 2020 An RNA-containing virus of the Vesivirus genus Caliciviridae family causes feline calicivirosis, a disease widely spread worldwide. The literature describes a systemic form of infection leading to the death of up to 60% of sick animals (FCV-VSD).
L. S. Koroleva +5 more
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Enhanced RNA cleavage within bulge-loops by an artificial ribonuclease. [PDF]
Nucleic Acids Res, 2005 Cleavage of phosphodiester bonds by small ribonuclease mimics within different bulge-loops of RNA was investigated. Bulge-loops of different size (1-7 nt) and sequence composition were formed in a 3' terminal fragment of influenza virus M2 RNA (96 nt) by hybridization of complementary oligodeoxynucleotides. Small bulges (up to 4 nt) were readily formed
Kuznetsova IL +3 more
europepmc +4 more sources
Molecules, 2017 In this report, we investigate the efficiency and selectivity of a Zn2+-dependent peptide nucleic acid-based artificial ribonuclease (PNAzyme) that cleaves RNA target sequences. The target RNAs are varied to form different sizes (3 and 4 nucleotides, nt)
Merita Murtola +3 more
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The effect of ribonuclease on phage-host interaction [PDF]
, 1954 SUMMARY: Pancreatic ribonuclease inhibits the multiplication of a Rhizobium bacteriophage in liquid bacterial cultures by preventing permanent combination between phage and host.
Kleczkowski, A.
core +1 more source
Further Probing of Cu2+-Dependent PNAzymes Acting as Artificial RNA Restriction Enzymes
Molecules, 2019 Peptide nucleic acid (PNA)-neocuproine conjugates have been shown to efficiently catalyse the cleavage of RNA target sequences in the presence of Cu2+ ions in a site-specific manner. These artificial enzymes are designed to force the formation of a bulge
Olivia Luige +3 more
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Rethinking Leucine Zipper : ribonuclease activity and structural dynamics of a ubiquitous oligomerization motif [PDF]
, 2011 This dissertation focuses on structural, dynamic and catalytic properties of a Leucine Zipper (LZ) motif – a family of protein oligomerization domains which belong to the structural class of coiled coil proteins.
Nikolaev, Yaroslav
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Target-directed catalytic metallodrugs
Brazilian Journal of Medical and Biological Research, 2013 Most drugs function by binding reversibly to specific biological targets, and therapeutic effects generally require saturation of these targets.
J.C. Joyner, J.A. Cowan
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