Results 11 to 20 of about 1,576,930 (245)
An Artificial Imine Reductase based on the Ribonuclease S Scaffold
ChemCatChem, 2014 AbstractDative anchoring of a piano‐stool complex within ribonuclease S resulted in an artificial imine reductase. The catalytic performance was modulated upon variation of the coordinating amino acid residues in the S‐peptide. Binding of Cp*Ir (Cp*=C5Me5) to the native active site resulted in good conversions and moderate enantiomeric excess values ...
Maika Genz +6 more
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RNase T1 mimicking artificial ribonuclease. [PDF]
Nucleic Acids Res, 2007 Recently, artificial ribonucleases (aRNases)--conjugates of oligodeoxyribonucleotides and peptide (LR)(4)-G-amide--were designed and assessed in terms of the activity and specificity of RNA cleavage. The conjugates were shown to cleave RNA at Pyr-A and G-X sequences. Variations of oligonucleotide length and sequence, peptide and linker structure led to
Mironova NL +5 more
europepmc +4 more sources
Organomercury oligonucleotide conjugates as artificial ribonucleases
Journal of Inorganic Biochemistry, 2023 Two oligonucleotide conjugates sharing the same sequence but incorporating a different 5'-terminal organometallic moiety were synthesized, by either direct mercuration in solution or oximation with an organomercury aldehyde on solid support. The potential of these conjugates to serve as new type of artificial ribonucleases was tested with a ...
Saleh Lange.Y. +2 more
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Development of artificial ribonucleases [PDF]
Pure and Applied Chemistry, 1998 Abstract
Robert Häner +3 more
openaire +1 more source
Development of Site-specific Artificial Ribonucleases [PDF]
Nucleic Acids Symposium Series, 2007 Recently we found that an antisense 2'-O-methyloligonucleotide, with two terpyridine*Cu(II) complexes at contiguous internal sites, was highly active as a site-specific (sequence-specific) artificial ribonuclease, with the activity derived from the cooperative action of the complexes.
Hiroshi, Takayama +3 more
openaire +2 more sources
Molecules, 2017 In this report, we investigate the efficiency and selectivity of a Zn2+-dependent peptide nucleic acid-based artificial ribonuclease (PNAzyme) that cleaves RNA target sequences. The target RNAs are varied to form different sizes (3 and 4 nucleotides, nt)
Merita Murtola +3 more
doaj +1 more source
The effect of ribonuclease on phage-host interaction [PDF]
, 1954 SUMMARY: Pancreatic ribonuclease inhibits the multiplication of a Rhizobium bacteriophage in liquid bacterial cultures by preventing permanent combination between phage and host.
Kleczkowski, A.
core +1 more source
Further Probing of Cu2+-Dependent PNAzymes Acting as Artificial RNA Restriction Enzymes
Molecules, 2019 Peptide nucleic acid (PNA)-neocuproine conjugates have been shown to efficiently catalyse the cleavage of RNA target sequences in the presence of Cu2+ ions in a site-specific manner. These artificial enzymes are designed to force the formation of a bulge
Olivia Luige +3 more
doaj +1 more source
Construction of Ribonuclease-Decorated Artificial Virus-like Capsid by Peptide Self-assembly [PDF]
Artificial virus-like capsids decorated with ribonuclease S (RNase S) on their exterior were constructed by the self-assembly of β-annulus-S-peptide and the interaction between S-peptide moiety and S-protein.
Matsuura, Kazunori +17 more
core +2 more sources
Structure and evolution of pancreatic ribonuclease [PDF]
, 1979 Dit proefschrift gaat over de structuur en de evolutie van het spijsverteringsenzym ribonuclease. In het eerste hoofdstuk wordt in het kort de stand van zaken beschreven in de eiwitchemie, waarvoor ribonuclease aI drie decennia dienst doet aIs ...
Lenstra, Johannes Arjen
core +4 more sources