Results 1 to 10 of about 723,122 (201)

The synthesis of polyamide-oligonucleotide conjugate molecules.

Nucleic Acids Research, 1990
We have developed methods for the synthesis of peptide-oligodeoxyribonucleotide conjugate molecules in particular, and polyamide-oligonucleotide conjugates in general.
J. Haralambidis, Lucy Duncan, K. Angus, G. Tregear   +3 more
semanticscholar   +2 more sources

Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes

Proceedings of the National Academy of Sciences of the United States of America, 2011
Basic peptides covalently linked to nucleic acids, or chemically modified nucleic acids, enable the insertion of such a conjugate into bacteria grown in liquid medium and mammalian cells in tissue culture.
D. Wesolowski, H. Tae, Neeru Gandotra, P. Llopis, N. Shen, S. Altman   +5 more
semanticscholar   +2 more sources

Inducible Alkylation of DNA by a Quinone Methide-Peptide Nucleic Acid Conjugate

Biochemistry, 2012
The reversibility of alkylation by a quinone methide intermediate (QM) avoids the irreversible consumption that plagues most reagents based on covalent chemistry and allows for site specific reaction that is controlled by the thermodynamics rather than ...
Yang Liu, S. Rokita
semanticscholar   +1 more source

Novel Convenient Approach to the Solid-Phase Synthesis of Oligonucleotide Conjugates

Molecules, 2019
A novel and convenient approach for the solid-phase 5′-functionalization of oligonucleotides is proposed in this article. The approach is based on the activation of free 5′-hydroxyl of polymer support-bound protected oligonucleotides by N,N ...
M. Meschaninova, D. Novopashina, O. Semikolenova, V. Silnikov, A. Venyaminova   +4 more
semanticscholar   +1 more source

Corrigendum: A Nanomule Peptide Carrier Delivers siRNA Across the Intact Blood-Brain Barrier to Attenuate Ischemic Stroke

Frontiers in Molecular Biosciences, 2021
Brett A. Eyford, Brett A. Eyford, Brett A. Eyford, Brett A. Eyford, Chaahat S. B. Singh, Chaahat S. B. Singh, Chaahat S. B. Singh, Chaahat S. B. Singh, Chaahat S. B. Singh, Thomas Abraham, Lonna Munro, Lonna Munro, Kyung Bok Choi, Kyung Bok Choi, Tracy Hill, Rhonda Hildebrandt, Ian Welch, Timothy Z. Vitalis, Timothy Z. Vitalis, Reinhard Gabathuler, Reinhard Gabathuler, Jacob A. Gordon, Jacob A. Gordon, Hans Adomat, Hans Adomat, Emma S.T. Guns, Emma S.T. Guns, Chieh-Ju Lu, Chieh-Ju Lu, Chieh-Ju Lu, Chieh-Ju Lu, Cheryl G. Pfeifer, Cheryl G. Pfeifer, Cheryl G. Pfeifer, Cheryl G. Pfeifer, Mei Mei Tian, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies   +43 more
doaj   +1 more source

Gene silencing using a conjugate comprising Tat peptide and antisense oligonucleotide with phosphorothioate backbones.

Bioorganic & Medicinal Chemistry Letters, 2016
Yoshiya Maegawa, S. Mochizuki, Noriko Miyamoto, K. Sakurai   +3 more
semanticscholar   +1 more source

Combined effect of a peptide–morpholino oligonucleotide conjugate and a cell-penetrating peptide as an antibiotic

Proceedings of the National Academy of Sciences of the United States of America, 2013
D. Wesolowski, Dulce Alonso, S. Altman
semanticscholar   +1 more source

Synthesis of Antisense Oligonucleotide−Peptide Conjugate Targeting to GLUT-1 in HepG-2 and MCF-7 Cells

Bioconjugate Chemistry, 2002
Li-He Zhang, Kwok-Pui Fung
exaly   +2 more sources

Total Stepwise Solid-Phase Peptide-Oligonucleotide Conjugate Synthesis on Macroporous Polystyrene

Nucleosides, Nucleotides and Nucleic Acids, 2003
Dmitry Stetsenko, Michael J Gait
exaly   +2 more sources

PDL1-binding peptide/anti-miRNA21 conjugate as a therapeutic modality for PD-L1high tumors and TAMs.

Journal of Controlled Release, 2022
Upregulation of oncogenic miRNA21 (miR-21) plays a pivotal role in proliferation, migration and invasion of cancer cells. In addition to cancer cells, tumor-associated macrophages (TAMs) also have high abundance of miR-21, which accelerates malignant ...
Eun Hye Kim, Jongwon Lee, Gijung Kwak, Hochung Jang, Hyosuk Kim, Haeun Cho, Yeongji Jang, Jiwoong Choi, Sung-Gil Chi, Kwangmeyung Kim, I. Kwon, Yoosoo Yang, Sun Hwa Kim   +12 more
semanticscholar   +1 more source