Results 1 to 10 of about 20,124 (257)
Generation and Characterization of a DNA-GCN4 Oligonucleotide-Peptide Conjugate: The Impact DNA/Protein Interactions on the Sensitization of DNA. [PDF]
Molecules, 2020 Radiotherapy, the most common therapy for the treatment of solid tumors, exerts its effects by inducing DNA damage. To fully understand the extent and nature of this damage, DNA models that mimic the in vivo situation should be utilized.
Wityk P +3 more
europepmc +6 more sources
Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation [PDF]
Frontiers in Chemistry, 2021 Cell penetrating peptides (CPPs) are being increasingly used as efficient vectors for intracellular delivery of biologically active agents, such as therapeutic antisense oligonucleotides (ASOs).
Mohadeseh Dastpeyman +5 more
doaj +2 more sources
2025 FDA TIDES (Peptides and Oligonucleotides) Harvest [PDF]
Pharmaceuticals (Basel)In 2025, the FDA approved 46 novel drugs, including four TIDEs (one peptide, three oligonucleotides, and one antibody drug conjugate containing peptide as a payload). The three approved oligonucleotide therapeutics—fitusiran, donidalorsen, and plozasiran—
AlShaer D +3 more
europepmc +2 more sources
Molecular Pharmaceutics, 2012 Nanoparticle-based delivery has become an important strategy to advance therapeutic oligonucleotides into clinical reality. Delivery by nanocarriers can enhance access of oligonucleotides to their pharmacological targets within cells; preferably ...
Xin Ming
exaly +3 more sources
Fluorescence Imaging of Extracellular Potassium Ion Using Potassium Sensing Oligonucleotide
Frontiers in Chemistry, 2022 Potassium-sensing oligonucleotide, PSO, a conjugate of a quadruplex structure-forming oligonucleotide with a peptide incorporating a Förster Resonance Energy Transfer (FRET) chromophore pair, has been developed for fluorescent detection of potassium ion (
Shinobu Sato +8 more
doaj +1 more source
Pharmaceutics, 2023 Currently, oligonucleotide therapy has emerged as a new paradigm in the treatment of human diseases. In many cases, however, therapeutic oligonucleotides cannot be used directly without modification.
Irina V. Varizhuk +6 more
doaj +1 more source
A Review of Protein- and Peptide-Based Chemical Conjugates: Past, Present, and Future
Pharmaceutics, 2023 Over the past few decades, the complexity of molecular entities being advanced for therapeutic purposes has continued to evolve. A main propellent fueling innovation is the perpetual mandate within the pharmaceutical industry to meet the needs of novel ...
Emily Holz +3 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 The blood-brain barrier (BBB) hinders the distribution of therapeutics intended for treatment of neuroinflammation (NI) of the central nervous system. A twelve-amino acid peptide that transcytoses the BBB, termed MTfp, was chemically conjugated to siRNA ...
Brett A. Eyford +42 more
doaj +1 more source
Molecules, 2021 RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are currently ...
Yaroslav Staroseletz +7 more
doaj +1 more source
RNA-Peptide Conjugation through an Efficient Covalent Bond Formation
Applied Sciences, 2020 Many methods for modification of an oligonucleotide with a peptide have been developed to apply for the therapeutic and diagnostic applications or for the assembly of nanostructure.
Shun Nakano +3 more
doaj +1 more source