Results 31 to 40 of about 723,122 (201)

Method of expanded porphyrin-oligonucleotide conjugate synthesis [PDF]

, 1995
The invention is directed to a method of incorporating expanded porphyrins, and particularly of incorporating a sapphyrin or a texaphyrin, before, during, or after chemical synthesis of an oligomer to form an expanded porphyrin-oligonucleotide conjugate,
Magda, Darren, Iverson, Brent L., Sessler, Jonathan L., Crofts, Shaun P., Sansom, Petra I.   +4 more
core   +1 more source

Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase

Molecules, 2019
Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and ...
Ian J. Huggins, Carlos A. Medina, Aaron D. Springer, Arjen van den Berg, Satish Jadhav, Xianshu Cui, Steven F. Dowdy   +6 more
doaj   +1 more source

Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model

Frontiers in Pharmacology, 2019
Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases ...
Olga A. Patutina, Svetlana K. Miroshnichenko, Nadezhda L. Mironova, Aleksandra V. Sen’kova, Elena V. Bichenkova, David J. Clarke, Valentin V. Vlassov, Marina A. Zenkova   +7 more
doaj   +1 more source

2025 FDA TIDES (Peptides and Oligonucleotides) Harvest

Pharmaceuticals
In 2025, the FDA approved 46 novel drugs, including four TIDEs (one peptide, three oligonucleotides, and one antibody drug conjugate containing peptide as a payload). The three approved oligonucleotide therapeutics—fitusiran, donidalorsen, and plozasiran—
Danah AlShaer, Othman Al Musaimi, Fernando Albericio, Beatriz G. de la Torre   +3 more
doaj   +1 more source

Peptide-oligonucleotide conjugates exhibiting pyrimidine-X cleavage specificity efficiently silence miRNA target acting synergistically with RNase H

Scientific Reports, 2018
Taking into account the important role of miRNA in carcinogenesis, oncogenic miRNAs are attractive molecules for gene-targeted therapy. Here, we developed a novel series of peptide-oligonucleotide conjugates exhibiting ribonuclease activity targeted to ...
O. Patutina, M. A. Bazhenov, S. Miroshnichenko, N. Mironova, D. Pyshnyi, V. Vlassov, M. Zenkova   +6 more
semanticscholar   +1 more source

Novel approaches to oligonucleotide conjugation to a cell penetrating (Tat) peptide [PDF]

, 2009
Modifed oligonucleotides are routinely employed as bioanalytical probes for use in diagnostics; however, a major limiting factor in oligonucleotide-based diagnostics is poor cellular uptake.
Steven, Victoria
core   +16 more sources

High-Resolution HPLC for Separating Peptide–Oligonucleotide Conjugates

ACS Omega
Peptide–oligonucleotide conjugates (POCs) are chimeric molecules that combine the specificity of oligonucleotides with the functionality of peptides, improving the delivery and therapeutic potential of nucleic acid-based drugs.
Miyako Naganuma, Genichiro Tsuji, Misato Amiya, Reira Hirai, Yuki Higuchi, Naoko Hata, Saoko Nozawa, Daishi Watanabe, Taeko Nakajima, Y. Demizu   +9 more
semanticscholar   +1 more source

Peptide catalyzed conjugate addition reactions of aldehydes to nitroolefins [PDF]

, 2013
In this thesis mechanistic investigations into the peptide catalyzed conjugate addition reaction between aldehydes and nitroolefins are described.
Duschmalé, Jörg
core   +1 more source

Peptide−Oligonucleotide Conjugates Form Stable and Selective Complexes with Antibody and DNA

, 2016
The present work demonstrates that the relatively low molecular weight synthetic peptide−oligonucleotide conjugates are capable of stable and selective three-component complex formation with complementary 72−100mer DNA oligonucleotides and a cardiac ...
Alex Azhayev (2429830), Tuula Tennilä (2429827), Maxim Antopolsky (1443790), Elena Azhayeva (2429833)   +3 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source