Results 51 to 60 of about 20,124 (257)

Oligodeoxynucleotides Modified with 2O(Cysteinylaminobutyl)carbamoylethylribothymidine Residues for Native Chemical Ligation with Peptide at Internal Positions

, 2022
We used native chemical ligation (NCL) to synthesize a 2′-O-{N-[N-(S-tert-butylthiocysteinyl)­aminobutyl]­carbamoylethyl} (CysBCE) ribothymidine-derived oligonucleotide to expand the variety of peptide conjugation sites, allowing the incorporation of ...
Atsuya Maruyama, Takahito Tomori (1633387), Takahito Tomori, Kohji Seio, Yoshiaki Masaki (1269162), Yoshiaki Masaki, Tomohiro Kishimura (12055664), Kohji Seio (107992), Keita Yoshida, Atsuya Maruyama (12055661), Keita Yoshida (603890), Tomohiro Kishimura   +11 more
core   +1 more source

A Bioinspired Three‐Dimensional High‐Curvature Nano‐Interface Integrated Microfluidic Chip for Small Extracellular Vesicles Enrichment and Machine Learning‐Assisted Prostate Cancer Precision Diagnosis

Advanced Science, EarlyView.
A biotin‐modified artificial insertion peptide functionalized three‐dimensional high‐curvature‐TiO2 nano‐interface was engineered in a microfluidic chip to improve the isolation efficiency of small extracellular vesicles (sEVs). This chip balanced affinity, releasability, and extendibility, enabling high‐throughput recovery of sEVs for downstream ...
Le Wang, Yizhong Liang, Manan Sulaiman, Jiaqi Du, Ming Jiang, Zhihua Wang, Xu Yu, Li Xu   +7 more
wiley   +1 more source

Cationic Oligonucleotide−Peptide Conjugates with Aggregating Properties Enter Efficiently into Cells while Maintaining Hybridization Properties and Enzymatic Recognition

, 2016
Oligonucleotide delivery is a crucial issue for therapeutical purposes and is often addressed by conjugation to short cationic peptides although with controversial results.
Deniz Dalkara (258466), Gérard Nullans (2530699), Andrew W. Fraley (2530702), Bénédicte Pons (2530696), Guy Zuber (2293897), Jean-Paul Behr (2017954)   +5 more
core   +1 more source

Design and Evaluation of a Novel Peptide–Drug Conjugate Covalently Targeting SARS-CoV-2 Papain-like Protease

, 2022
Coronavirus disease 2019 (COVID-19) pandemic, a global health threat, was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 papain-like cysteine protease (PLpro) was recognized as a promising drug target because of ...
Zhang, Yichi, Zhan, Meimiao, An, Yuhao, Zhan, Jian, Liu, Na, Zhou, Yaoqi, Li, Zigang, Yin, Feng, Liu, Jianbo, Lei, Yingshou, Wang, Rui   +10 more
core   +1 more source

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Synthesis of a Peptide-Human Telomere DNA Conjugate as a Fluorometric Imaging Reagent for Biological Sodium Ion

, 2019
A peptide-oligonucleotide conjugate (1) was synthesized by the attachment of FAM, TAMRA, and biotin moieties to a telomere DNA sequence of 5′-TAG GGT TAG GGT TAG GGT TAG GG-3′.
24989, Nakazawa, Koji, Takenaka, Shigeori, 7202789037, サトウ, シノブ, Sato, Shinobu, 24988, 395, 24987, Yoshiura, Yukiko, 竹中, 繁織, 7501769466, 60188208, Imaichi, Yuuki, 5963, 佐藤, しのぶ, タケナカ, シゲオリ, 80510677, 6749   +18 more
core   +2 more sources

Hepatoma‐Derived Growth Factor Coordinates STAT3 Pathway and Exosome‐Mediated Intrahepatic Crosstalk to Control Hepatic Steatosis and MASLD

Advanced Science, EarlyView.
Hepatic HDGF as a key mediator in coordinating hepatic steatosis and intrahepatic crosstalk in MASLD. Activation of HDGF facilitates its interaction with both STAT3 and S6K1, driving the S6K1‐dependent STAT3 phosphorylation and subsequently enhancing hepatic lipogenesis.
Jian Wen, Dong Ding, Zengpeng Zheng, Xufeng Chen, Wenjing Li, Jiaxin Shen, Zhiwei Huang, Peng Tan, Junjie Bai, Xia Fang, Baofang Xing, Puyuan Hu, Linghao Xu, Haokai Yu, Yixi Wang, Zongzhe Jiang, Yang Long, Tiejun Zhou, Mingxin Ye, Yu Jiang, Aoyuan Cui, Hong Li, Qiurong Ding, Yong Xu, Yu Li, Weitong Su, Feng Shen, Chenlin Gao, Wenguang Fu   +28 more
wiley   +1 more source

Novel approaches to oligonucleotide conjugation to a cell penetrating (Tat) peptide

, 2009
Modifed oligonucleotides are routinely employed as bioanalytical probes for use in diagnostics; however, a major limiting factor in oligonucleotide-based diagnostics is poor cellular uptake.
Steven, Victoria
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source