Anti-Metastatic Effects on Melanoma via Intravenous Administration of Anti-NF-κB siRNA Complexed with Functional Peptide-Modified Nano-Micelles [PDF]
Pharmaceutics, 2020 Controlling metastasis is an important strategy in cancer treatment. Nanotechnology and nucleic acids with novel modalities are promising regulators of cancer metastasis.
Hisako Ibaraki +5 more
doaj +2 more sources
TME-Responsive Multistage Nanoplatform for siRNA Delivery and Effective Cancer Therapy
International Journal of Nanomedicine, 2021 Shuwen Cao,1,2 Chunhao Lin,1,2 Xiuling Li,1,2 Yixia Liang,1,2 Phei Er Saw1,2 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ...
Cao S, Lin C, Li X, Liang Y, Saw PE
doaj +3 more sources
Blockade of CD73 Increases the Cytotoxic Effects of Fludarabine in Chronic Lymphocytic Leukemia [PDF]
ImmunoAnalysis, 2022 Background: Ecto-5’-nucleotidase (CD73) is a membrane-bound enzyme that converts adenosine 5’-monophosphate into adenosine. It is proven that the presence of elevated levels of adenosine in the tumor microenvironment induces tumor growth while ...
Mohammad Sadeghi +5 more
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THE EFFECT OF SILENCING THE Tip60 GENE ON THE RESPONSE TO RADIOTHERAPY IN BREAST CANCER CELLS
Sabiad, 2022 One of the most important problems encountered in patients with triple-negative breast cancer (BC) treatment is the inadequate response of tumor tissue to treatment.
Ece Miser Salihoğlu +2 more
doaj +1 more source
Effect of antiviral siRNAs on the production of cytokines in vitro
Тонкие химические технологии, 2022 Objectives. To evaluate the dynamics of the expression level of IL-1β and IL-28β (IFN-λ3) genes as a result of complex knockdown of some cellular genes, whose expression products play an important role in the reproduction of the influenza virus.Methods ...
A. V. Pak +8 more
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Progress in RNA-targeting and Gene Editing Therapies for Transthyretin Amyloidosis Cardiomyopathy
罕见病研究, 2023 Transthyretin(TTR) protein is a tetramer protein, synthesized mainly by the liver. TTR can be misfolded and deposited as amyloid fibrilae and deposited in the myocardial interstroma leading to transthyroxin amyloidosis cardiomyopathy (ATTR-CM).
NIU Ziran +6 more
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Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis [PDF]
, 2020 Strategies for controlled delivery of therapeutic siRNA into living cells are in high demand as endosomal escape remains the most prominent bottleneck at the intracellular level.
Barriga, Gerardo Garcia-Diaz +16 more
core +3 more sources
Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9[S]
Journal of Lipid Research, 2011 Reducing circulating LDL-cholesterol (LDL-c) reduces the risk of cardiovascular disease in people with hypercholesterolemia. Current approaches to reduce circulating LDL-c include statins, which inhibit cholesterol synthesis, and ezetimibe, which blocks ...
Brandon Ason +18 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2019 Drug combinations can improve the control of diseases involving redundant and highly regulated pathways. Validating a multi-target therapy early in drug development remains difficult.
Radu Mihaila +14 more
doaj +1 more source
The influence of natural pulmonary surfactant on the efficacy of siRNA-loaded dextran nanogels [PDF]
, 2013 Aim: Topical administration of siRNA nanocarriers is a promising approach in the treatment of pulmonary disorders. Pulmonary surfactant, covering the entire alveolar surface of mammalian lungs, will be one of the first interfaces that siRNA nanocarriers ...
Braeckmans, Kevin +4 more
core +1 more source