Results 1 to 10 of about 535,239 (304)
Blockade of CD73 Increases the Cytotoxic Effects of Fludarabine in Chronic Lymphocytic Leukemia [PDF]
ImmunoAnalysis, 2022 Background: Ecto-5’-nucleotidase (CD73) is a membrane-bound enzyme that converts adenosine 5’-monophosphate into adenosine. It is proven that the presence of elevated levels of adenosine in the tumor microenvironment induces tumor growth while ...
Mohammad Sadeghi +5 more
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THE EFFECT OF SILENCING THE Tip60 GENE ON THE RESPONSE TO RADIOTHERAPY IN BREAST CANCER CELLS
Sabiad, 2022 One of the most important problems encountered in patients with triple-negative breast cancer (BC) treatment is the inadequate response of tumor tissue to treatment.
Ece Miser Salihoğlu +2 more
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Effect of antiviral siRNAs on the production of cytokines in vitro
Тонкие химические технологии, 2022 Objectives. To evaluate the dynamics of the expression level of IL-1β and IL-28β (IFN-λ3) genes as a result of complex knockdown of some cellular genes, whose expression products play an important role in the reproduction of the influenza virus.Methods ...
A. V. Pak +8 more
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Molecular Cell, 2004 An array of gene silencing pathways share a common early step: Dicer cleaves double-stranded RNA (dsRNA) into approximately 20-25 nucleotide fragments that direct the silencing machinery to specific targets. A recent report in Cell reveals how Dicer's two RNase III domains collaborate during dsRNA processing and sets the stage for a deeper ...
Pham, John W, Sontheimer, Erik J
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Filtering of Ineffective siRNAs and Improved siRNA Design Tool [PDF]
Bioinformatics, 2004 Abstract Motivation: Short interfering RNAs (siRNAs) can be used to suppress gene expression and possess many potential applications in therapy, but how to design an effective siRNA is still not clear. Based on the MPI (Max-Planck-Institute) basic principles, a number of siRNA design tools have been developed recently.
Siu-Ming Yiu +6 more
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Targeted Delivery of siRNA [PDF]
BioMed Research International, 2006 Therapeutic application of siRNA requires delivery to the correct intracellular location, to interact with the RNAi machinery within the target cell, within the target tissue responsible for the pathology. Each of these levels of targeting poses a significant barrier.
Oliveira, S. +2 more
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Progress in RNA-targeting and Gene Editing Therapies for Transthyretin Amyloidosis Cardiomyopathy
罕见病研究, 2023 Transthyretin(TTR) protein is a tetramer protein, synthesized mainly by the liver. TTR can be misfolded and deposited as amyloid fibrilae and deposited in the myocardial interstroma leading to transthyroxin amyloidosis cardiomyopathy (ATTR-CM).
NIU Ziran +6 more
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Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9[S]
Journal of Lipid Research, 2011 Reducing circulating LDL-cholesterol (LDL-c) reduces the risk of cardiovascular disease in people with hypercholesterolemia. Current approaches to reduce circulating LDL-c include statins, which inhibit cholesterol synthesis, and ezetimibe, which blocks ...
Brandon Ason +18 more
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Molecular Therapy: Nucleic Acids, 2019 Drug combinations can improve the control of diseases involving redundant and highly regulated pathways. Validating a multi-target therapy early in drug development remains difficult.
Radu Mihaila +14 more
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Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing
Journal of Lipid Research, 2012 Microsomal triglyceride transfer protein (Mtp) inhibitors represent a novel therapeutic approach to lower circulating LDL cholesterol, although therapeutic development has been hindered by the observed increase in hepatic triglycerides and liver ...
Samnang Tep +11 more
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