Results 31 to 40 of about 535,239 (304)
Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA
Molecular Therapy: Nucleic Acids, 2017 Lipid nanoparticles (LNPs) have been used to successfully deliver small interfering RNAs (siRNAs) to target cells in both preclinical and clinical studies and currently are the leading systems for in vivo delivery. Here, we propose the use of an ordinary
Radu Mihaila +9 more
doaj +1 more source
RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]
, 2013 Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Jo Milner +4 more
core +1 more source
siRNA-mediated Silencing of Peroxisomal Genes in Mammalian Cells
, 2017 RNAi technologies are a valuable tool in the identification and investigation of proteins which are involved in peroxisome biogenesis and function. Small interfering RNA (siRNA) has developed into the most commonly used RNAi tool for the induction of ...
M Schrader (16286) +1 more
core +6 more sources
Addis Ababa/Finfinee: A Blueprint towards Twin-city Administration
Ethiopian Journal of the Social Sciences and Humanities, 2018 This article analyses the challenge of Addis Ababa´s double status – both as capital of Ethiopia and that of the Regional State of Oromia. It delves into the unresolved issue of the special interest of Oromia in Addis Ababa/Finfinnee.
Zelalem T. Sirna
doaj +1 more source
Revue Européenne des Migrations Internationales, 2017 Migration studies often neglect return mobility or, on the contrary, the latter becomes the object of studies that do not consider the country where migrants settled, sometimes during years. Building on a critical understanding of “return”, this research
Blanchard Melissa, Sirna Francesca
doaj +1 more source
Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates
Nucleic Acids Research, 2020 One hallmark of trivalent N-acetylgalactosamine (GalNAc)-conjugated siRNAs is the remarkable durability of silencing that can persist for months in preclinical species and humans.
Christopher R. Brown +23 more
semanticscholar +1 more source
Beilstein Journal of Organic Chemistry, 2021 Over the past 25 years, the acceleration of achievements in the development of oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the market for the treatment of various diseases. Oligonucleotides with alterations to their
Christopher Liczner +4 more
doaj +1 more source
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity [PDF]
, 2009 The use of chemically synthesized short interfering RNAs (siRNAs) is currently the method of choice to manipulate gene expression in mammalian cell culture, yet improvements of siRNA design is expectably required for successful application in vivo ...
Laursen, Maria B. +42 more
core +1 more source
Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics.
Accounts of Chemical Research, 2019 Delivering nucleic acid-based therapeutics to cells is an attractive approach to target the genetic cause of various diseases. In contrast to conventional small molecule drugs that target gene products (i.e., proteins), genetic drugs induce therapeutic ...
Jayesh A. Kulkarni +4 more
semanticscholar +1 more source
Vaccines, 2020 The contactless high intensity pulsed electromagnetic field (HI-PEMF)-induced increase of cell membrane permeability is similar to conventional electroporation, with the important difference of inducing an electric field non-invasively by exposing a ...
Simona Kranjc Brezar +5 more
doaj +1 more source