Results 31 to 40 of about 411,726 (313)
, 2023 Supplementary Table 1. The major characteristics of CSPC and CRPC. CSPC, Castration-Sensitive Prostate Cancer; CRPC, Castration-Resistant Prostate Cancer.Supplementary Table 2. Interventional clinical trials of siRNA use for cancer.
Nino Rcheulishvili (11975999) +9 more
core +1 more source
Dendrimers for siRNA Delivery [PDF]
Pharmaceuticals, 2013 Since the discovery of the “starburst polymer”, later renamed as dendrimer, this class of polymers has gained considerable attention for numerous biomedical applications, due mainly to the unique characteristics of this macromolecule, including its monodispersity, uniformity, and the presence of numerous functionalizable terminal groups.
Swati Biswas, Vladimir P. Torchilin
openaire +3 more sources
Design of double-walled carbon nanotubes for biomedical applications [PDF]
, 2012 Double-walled carbon nanotubes (DWNTs) prepared by catalytic chemical vapour deposition were functionalized in such a way that they were optimally designed as a nano-vector for the delivery of small interfering RNA (siRNA), which is of great interest for
Coley, Helen M. +19 more
core +1 more source
Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems
Biomolecules, 2019 Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate ...
Shima Tavakol +13 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
siRNA-mediated Silencing of Peroxisomal Genes in Mammalian Cells
, 2017 RNAi technologies are a valuable tool in the identification and investigation of proteins which are involved in peroxisome biogenesis and function. Small interfering RNA (siRNA) has developed into the most commonly used RNAi tool for the induction of ...
M Schrader (16286) +1 more
core +3 more sources
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Screening for the optimal siRNA targeting a novel gene (HA117) and construction and evaluation of a derivative recombinant adenovirus [PDF]
, 2010 We found a novel gene named as HA117 in our previous research. At this study, we screened for an optimal siRNA targeting the novel gene HA117 using the pSOS-HUS method, verified the results of pSOS-HUS siRNA screening for optimal affinity for the target ...
Youhua Xu +4 more
core
Nuclear condensation and cell cycle arrest induced by telomerase siRNA in neuroblastoma cells
, 2017 Neuroblastoma is a type of malignant extracranial tumor that occurs in children. Advanced neuroblastoma, and tumors with MYCN amplification in particular, have poor prognoses. Therefore, it is important to find an effective cure for this disease.
Tsai, Ming-Dar;Chen, Pei-Rong;Tien, Lu-Tai;Cai, Yu-Jyun;Lee, Yih-Jing
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