Results 31 to 40 of about 382,657 (316)

A method for concentrating lipid peptide DNA and siRNA nanocomplexes that retains their structure and transfection efficiency.

, 2015
Nonviral gene and small interfering RNA (siRNA) delivery formulations are extensively used for biological and therapeutic research in cell culture experiments, but less so in in vivo and clinical research.
Hart, S.L., Zhou, Haiyan, Munye, Mustafa M, Hart, Stephen L, Munye, MM, Munye MM, Tagalakis AD, Tagalakis, Aristides D, Tagalakis, Aristides, White, Edward A, White, EA, Castellaro, S, Zhou, H, Zhou H, Castellaro S, White EA, Bienemann, A, White, E.A., McCarthy, David, Munye, M.M., Castellaro, Sara, Tagalakis, AD, Hart, SL, Bienemann, Ali S, McCarthy, D, Bienemann A, Hart SL, McCarthy D   +27 more
core   +1 more source

Dual-targeting siRNAs [PDF]

RNA, 2010
We have developed an algorithm for the prediction of dual-targeting short interfering RNAs (siRNAs) in which both strands are deliberately designed to separately target different mRNA transcripts with complete complementarity. An advantage of this approach versus the use of two separate duplexes is that only two strands, as opposed to four, are ...
Katrin, Tiemann, Britta, Höhn, Ali, Ehsani, Stephen J, Forman, John J, Rossi, Pål, Saetrom   +5 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

THE siRNA EFFICACY OF SOLUBLE ACID INVERTASE DOWN-REGULATION IN SUGARCANE (SACCHARUM SPP.) [PDF]

Arab Universities Journal of Agricultural Sciences, 2018
Sugarcane (Saccharum sp. hybrids) is a C4 grass used as a major source of sucrose. Invertase enzymes hydrolyse sucrose into hexose sugars reducing the production markedly.
Shereen K.M. Khaled, F.M. Abdel-Tawab, Eman M. Fahmy, E.A.M. Amer, K.A. Khaled   +4 more
doaj   +1 more source

Low energy vs. high energy depositional settings related sedimentary bodies in early Senonian rudist bearing carbonate shelves (central-southern Italy)

, 2001
Carannante Gabriele, Laviano A., Ruberti D., Simone Lucia, Sirna G., Sirna M., Tropeano M. Low energy vs. high energy depositional settings and related sedimentary bodies in early Senenian rudist bearing carbonate shelves (central-southern Italy).
SIRNA, Maurizio, LAVIANO A., CARANNANTE G, R. Graziano, SIRNA G, SIMONE, LUCIA, CARANNANTE G., Tropeano M., SIMONE L, CARANNANTE, GABRIELE, Sirna, M., Sirna M, Sirna, G., Laviano, A., GRAZIANO R., RUBERTI D., LAVIANO A, D. Ruberti, L. Simone, G. Sirna, SIRNA G., RUBERTI, Daniela, TROPEANO, MARCELLO, SIMONE L., SIRNA M., Ruberti, D., Tropeano, M., G. Carannante, LAVIANO, Angela   +28 more
core   +1 more source

Molecular genetic analysis of siRNA biogenesis and function in Arabidopsis thaliana [PDF]

, 2009
In diverse eukaryotes, small RNA products of Dicer-like (DCL) proteins regulate mRNA stability or translation, and direct chromatin modifications to genomic regions, phenomena collectively known as RNA silencing.
Blevins, Todd Lucas
core   +1 more source

siRNA applications in nanomedicine [PDF]

WIREs Nanomedicine and Nanobiotechnology, 2010
AbstractThe ability to specifically silence genes using RNA interference (RNAi) has wide therapeutic applications for the treatment of disease or the augmentation of tissue formation. RNAi is the sequence‐specific gene silencing mediated by a 21–25 nucleotide double‐stranded small interfering RNA (siRNA) molecule.
Talar, Tokatlian, Tatiana, Segura
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Study of LBHD1 Expression with Invasion and Migration of Bladder Cancer

Open Life Sciences, 2019
LBHD1 (C11ORF48) is one of the ten potential tumor antigens identified by immunoscreening the urinary bladder cancer cDNA library in our previous study. We suspect that its expression is associated with human bladder cancer.
Dong Chunhui, Liu Yihui, Yu Guiping, Li Xu, Chen Ling   +4 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source