Results 11 to 20 of about 535,239 (304)
Recent advances in siRNA delivery mediated by lipid-based nanoparticles
Advanced Drug Delivery Reviews, 2020 Small interfering RNA (siRNA) has been expected to be a unique pharmaceutic for the treatment of broad-spectrum intractable diseases. However, its unfavorable properties such as easy degradation in the blood and negative-charge density are still a ...
Hiroyuki Koide, Sei Yonezawa
exaly +2 more sources
Strategies, design, and chemistry in siRNA delivery systems
Advanced Drug Delivery Reviews, 2019 Emerging therapeutics that utilize RNA interference (RNAi) have the potential to treat broad classes of diseases due to their ability to reversibly silence target genes.
Daniel Griffith Anderson +2 more
exaly +2 more sources
Engineering siRNA therapeutics: challenges and strategies
Journal of Nanobiotechnology, 2023 Small interfering RNA (siRNA) is a potential method of gene silencing to target specific genes. Although the U.S. Food and Drug Administration (FDA) has approved multiple siRNA-based therapeutics, many biological barriers limit their use for treating ...
Syed Saqib Ali Zaidi +5 more
semanticscholar +1 more source
Therapeutic siRNA: State-of-the-Art and Future Perspectives
BioDrugs, 2022 The highly specific induction of RNA interference-mediated gene knockdown, based on the direct application of small interfering RNAs (siRNAs), opens novel avenues towards innovative therapies.
M. Friedrich, A. Aigner
semanticscholar +1 more source
The growth of siRNA-based therapeutics: updated clinical studies
Biochemical Pharmacology, 2021 More than two decades after the natural gene-silencing mechanism of RNA interference was elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the pharmaceutical market.
M. Zhang +4 more
semanticscholar +1 more source
Where should siRNAs go: applicable organs for siRNA drugs
Experimental and Molecular Medicine, 2023 RNA interference mediated by small interfering RNAs (siRNAs) has been exploited for the development of therapeutics. siRNAs can be a powerful therapeutic tool because the working mechanisms of siRNAs are straightforward. siRNAs determine targets based on
Insook Ahn, Chanhee S. Kang, Jinju Han
semanticscholar +1 more source
Therapeutic siRNA: state of the art
Signal Transduction and Targeted Therapy, 2020 RNA interference (RNAi) is an ancient biological mechanism used to defend against external invasion. It theoretically can silence any disease-related genes in a sequence-specific manner, making small interfering RNA (siRNA) a promising therapeutic ...
Bo Hu +6 more
semanticscholar +1 more source
Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome
Acta Pharmaceutica Sinica B, 2021 The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of several unmet medical needs, including acute lung injury/acute respiratory distress syndrome (ALI/ARDS) wherein siRNA may be implemented to modify the expression
Makhloufi Zoulikha +5 more
semanticscholar +1 more source
An Engineering Approach to Cancer Therapy Using Systemically Delivered siRNA [PDF]
, 2007 The next generation of cancer therapeutics will specifically target processes responsible for the growth and survival of cancer cells. Among the most promising of these molecularly targeted therapeutics are small interfering RNAs (siRNAs). These siRNAs
Bartlett, Derek William
core +1 more source
Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy [PDF]
, 2007 The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Here we demonstrate cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer. The
Haitang Li +4 more
core +1 more source