Results 11 to 20 of about 317,404 (266)
Molecular Cell, 2004 An array of gene silencing pathways share a common early step: Dicer cleaves double-stranded RNA (dsRNA) into approximately 20-25 nucleotide fragments that direct the silencing machinery to specific targets. A recent report in Cell reveals how Dicer's two RNase III domains collaborate during dsRNA processing and sets the stage for a deeper ...
Pham, John W, Sontheimer, Erik J
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Filtering of Ineffective siRNAs and Improved siRNA Design Tool [PDF]
Bioinformatics, 2004 Abstract Motivation: Short interfering RNAs (siRNAs) can be used to suppress gene expression and possess many potential applications in therapy, but how to design an effective siRNA is still not clear. Based on the MPI (Max-Planck-Institute) basic principles, a number of siRNA design tools have been developed recently.
Siu-Ming Yiu +6 more
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Targeted Delivery of siRNA [PDF]
BioMed Research International, 2006 Therapeutic application of siRNA requires delivery to the correct intracellular location, to interact with the RNAi machinery within the target cell, within the target tissue responsible for the pathology. Each of these levels of targeting poses a significant barrier.
Oliveira, S. +2 more
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Retrovirus-delivered siRNA [PDF]
BMC Biotechnology, 2002 The ability of transfected synthetic small interfering (si) RNAs to suppress the expression of specific transcripts has proved a useful technique to probe gene function in mammalian cells. However, high production costs limit this technology's utility for many laboratories and experimental situations.
Devroe, Eric, Silver, Pamela
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Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA
Molecular Therapy: Nucleic Acids, 2017 Lipid nanoparticles (LNPs) have been used to successfully deliver small interfering RNAs (siRNAs) to target cells in both preclinical and clinical studies and currently are the leading systems for in vivo delivery. Here, we propose the use of an ordinary
Radu Mihaila +9 more
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Addis Ababa/Finfinee: A Blueprint towards Twin-city Administration
Ethiopian Journal of the Social Sciences and Humanities, 2018 This article analyses the challenge of Addis Ababa´s double status – both as capital of Ethiopia and that of the Regional State of Oromia. It delves into the unresolved issue of the special interest of Oromia in Addis Ababa/Finfinnee.
Zelalem T. Sirna
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Revue Européenne des Migrations Internationales, 2017 Migration studies often neglect return mobility or, on the contrary, the latter becomes the object of studies that do not consider the country where migrants settled, sometimes during years. Building on a critical understanding of “return”, this research
Blanchard Melissa, Sirna Francesca
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Beilstein Journal of Organic Chemistry, 2021 Over the past 25 years, the acceleration of achievements in the development of oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the market for the treatment of various diseases. Oligonucleotides with alterations to their
Christopher Liczner +4 more
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Vaccines, 2020 The contactless high intensity pulsed electromagnetic field (HI-PEMF)-induced increase of cell membrane permeability is similar to conventional electroporation, with the important difference of inducing an electric field non-invasively by exposing a ...
Simona Kranjc Brezar +5 more
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MIL-101-NH2-mediated nucleic acid delivery and gene silencing
上海师范大学学报. 自然科学版, 2021 Nucleic acids, including DNA and RNA, can participate in the regulation of gene expression in all organisms. However, those nucleic acid molecules are easily to be degraded. If they are directly administered orally or intravenously, their bioavailability
AI Yichun +4 more
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