Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing
Journal of Lipid Research, 2012 Microsomal triglyceride transfer protein (Mtp) inhibitors represent a novel therapeutic approach to lower circulating LDL cholesterol, although therapeutic development has been hindered by the observed increase in hepatic triglycerides and liver ...
Samnang Tep +11 more
doaj +1 more source
Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy [PDF]
, 2007 The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Here we demonstrate cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer. The
Haitang Li +4 more
core +2 more sources
Journal of Lipid Research, 2011 Increased serum apolipoprotein (apo)B and associated LDL levels are well-correlated with an increased risk of coronary disease. ApoE–/– and low density lipoprotein receptor (LDLr)–/– mice have been extensively used for studies of coronary atherosclerosis.
Marija Tadin-Strapps +24 more
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Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA [PDF]
, 2019 Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by various extra-
De Backer, Lynn +7 more
core +1 more source
siRNA-optimized Modifications for Enhanced In Vivo Activity
Molecular Therapy: Nucleic Acids, 2012 Current modifications used in small interfering RNAs (siRNAs), such as 2’-methoxy (2’-OMe) and 2’-fluoro (2’-F), improve stability, specificity or immunogenic properties but do not improve potency.
Denise M Kenski +8 more
doaj +1 more source
Role of non-coding RNAs in Dengue virus-host interaction
Frontiers in Bioscience-Scholar, 2021 Dengue is potentially a life-threatening arthropod-borne viral infection for which there are no known therapeutic agents till date. Early stage diagnosis of dengue infection is still lacking.
Deeksha Madhry +8 more
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RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]
, 2013 Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Ahmed +38 more
core +2 more sources
Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA
Molecular Therapy: Nucleic Acids, 2017 Lipid nanoparticles (LNPs) have been used to successfully deliver small interfering RNAs (siRNAs) to target cells in both preclinical and clinical studies and currently are the leading systems for in vivo delivery. Here, we propose the use of an ordinary
Radu Mihaila +9 more
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Receptors for hyaluronic acid and poliovirus: a combinatorial role in glioma invasion? [PDF]
, 2012 CD44 has long been associated with glioma invasion while, more recently, CD155 has been implicated in playing a similar role. Notably, these two receptors have been shown closely positioned on monocytes.) on glioblastoma cell processes whereas siRNA ...
Maherally, Zaynah +3 more
core +5 more sources
Addis Ababa/Finfinee: A Blueprint towards Twin-city Administration
Ethiopian Journal of the Social Sciences and Humanities, 2018 This article analyses the challenge of Addis Ababa´s double status – both as capital of Ethiopia and that of the Regional State of Oromia. It delves into the unresolved issue of the special interest of Oromia in Addis Ababa/Finfinnee.
Zelalem T. Sirna
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