Results 41 to 50 of about 535,239 (304)

MIL-101-NH₂-mediated nucleic acid delivery and gene silencing

上海师范大学学报. 自然科学版, 2021
Nucleic acids, including DNA and RNA, can participate in the regulation of gene expression in all organisms. However, those nucleic acid molecules are easily to be degraded. If they are directly administered orally or intravenously, their bioavailability
AI Yichun, YUAN Xuejiao, YU Yicheng, LYU Min, CHEN Nan   +4 more
doaj   +1 more source

Carbon nanocarriers deliver siRNA to intact plant cells for efficient gene knockdown

Science Advances, 2020
Carbon nanoparticles, carrying small interfering RNA, enter plant cells to silence genes in plants. Posttranscriptional gene silencing (PTGS) is a powerful tool to understand and control plant metabolic pathways, which is central to plant biotechnology ...
Gozde S. Demirer, Huan Zhang, Natalie S. Goh, R. Pinals, Roger L. Chang, M. Landry   +5 more
semanticscholar   +1 more source

The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress

Drug development research (Print), 2019
Lung diseases are the leading cause of mortality worldwide. The currently available therapies are not sufficient, leading to the urgent need for new therapies with sustained anti‐inflammatory effects.
K. Dua, Ridhima Wadhwa, Gautam Singhvi, V. Rapalli, S. Shukla, M. Shastri, G. Gupta, S. Satija, Meenu Mehta, N. Khurana, R. Awasthi, P. K. Maurya, Lakshmi Thangavelu, R. S., M. Tambuwala, T. Collet, P. Hansbro, D. Chellappan   +17 more
semanticscholar   +1 more source

Synthesis of Cationic and Ionizable Amphiphiles Based on Heminal Aminodiol as Potential siRNA Delivery Systems

Тонкие химические технологии, 2019
Research methods based on the use of RNA interference mechanisms are now included among the basic methods of molecular biology. Drugs based on siRNA are being developed for the treatment of cancer, infectious diseases and other pathologies that are ...
Z. G. Denieva, U. A. Budanova, Yu. L. Sebyakin   +2 more
doaj   +1 more source

siRNA-mediated downregulation of HMB45 in differentiated ADSCs.

, 2021
siRNA resulted in the downregulation of HMB45 in undifferentiated ADSCs and differentiated ADSCs.
Yuri Ikeda (7360736), Toshio Hasegawa (695821), Masato Koike (209042), Mutsumi Yokota (9668895), Akino Wada (695823), Shigaku Ikeda (695826)   +5 more
core   +1 more source

Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy

Science Advances, 2020
Glycosylated “triple-interaction” stabilized siRNA nanomedicine ameliorated AD neuropathology by targeting BACE1. Toxic aggregated amyloid-β accumulation is a key pathogenic event in Alzheimer’s disease (AD), which derives from amyloid precursor protein (
Yutong Zhou, Feiyan Zhu, Yang Liu, Meng Zheng, Yibin Wang, Dongya Zhang, Y. Anraku, Yan Zou, Jia Li, Haigang Wu, Xiaobin Pang, Wei Tao, O. Shimoni, A. Bush, Xue Xue, Bingyang Shi   +15 more
semanticscholar   +1 more source

Digital modeling by biomedical informatics analysis predicts suppression of COVID-19 infectivity via ‘targeting oligonucleotide-directed devolution’ [PDF]

Exploration of Digital Health Technologies
Aim: Genetic instability represents the hallmark of carcinogenesis. For cancer, the retinoblastoma (RB) gene defect allowing genetic instability was successfully exploited to eliminate cancer.
Frank-Un Hong, Miguel Marciano Castro, Klaus D. Linse   +2 more
doaj   +1 more source

Anti-Metastatic Effects on Melanoma via Intravenous Administration of Anti-NF-κB siRNA Complexed with Functional Peptide-Modified Nano-Micelles

Pharmaceutics, 2020
Controlling metastasis is an important strategy in cancer treatment. Nanotechnology and nucleic acids with novel modalities are promising regulators of cancer metastasis.
Hisako Ibaraki, Takanori Kanazawa, Minami Owada, Keiko Iwaya, Yuuki Takashima, Yasuo Seta   +5 more
doaj   +1 more source

Molecular genetic analysis of siRNA biogenesis and function in Arabidopsis thaliana [PDF]

, 2009
In diverse eukaryotes, small RNA products of Dicer-like (DCL) proteins regulate mRNA stability or translation, and direct chromatin modifications to genomic regions, phenomena collectively known as RNA silencing.
Blevins, Todd Lucas
core   +1 more source

The Landscape of Nanoparticle-based siRNA Delivery and Therapeutic Development.

Molecular Therapy
Five siRNA-based therapeutics have been approved by the Food and Drug Administration (FDA), including patisiran, givosiran, lumasiran, inclisiran and vutrisiran.
Muhammad Moazzam, Mengjie Zhang, Abid Hussain, Xiaotong Yu, Jia Huang, Yuanyu Huang   +5 more
semanticscholar   +1 more source