Results 41 to 50 of about 411,726 (313)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Study of LBHD1 Expression with Invasion and Migration of Bladder Cancer

Open Life Sciences, 2019
LBHD1 (C11ORF48) is one of the ten potential tumor antigens identified by immunoscreening the urinary bladder cancer cDNA library in our previous study. We suspect that its expression is associated with human bladder cancer.
Dong Chunhui, Liu Yihui, Yu Guiping, Li Xu, Chen Ling   +4 more
doaj   +1 more source

THE siRNA EFFICACY OF SOLUBLE ACID INVERTASE DOWN-REGULATION IN SUGARCANE (SACCHARUM SPP.) [PDF]

Arab Universities Journal of Agricultural Sciences, 2018
Sugarcane (Saccharum sp. hybrids) is a C4 grass used as a major source of sucrose. Invertase enzymes hydrolyse sucrose into hexose sugars reducing the production markedly.
Shereen K.M. Khaled, F.M. Abdel-Tawab, Eman M. Fahmy, E.A.M. Amer, K.A. Khaled   +4 more
doaj   +1 more source

PepFect6 Mediated SiRNA Delivery into Organotypic Cultures

, 2016
Gene silencing by small interfering RNA (SiRNA) is an attractive therapeutic approach for pathological disorders that targets a specific gene. However, its applications are limited, as naked RNA is rapidly degraded by RNases and is inadequately ...
Ulfendahl, Mats, Mats Ulfendahl, Ülo Langel, Langel, Ülo,, Langel, Ü, Dash-Wagh, S,, Suvarna Dash-Wagh, Dash-Wagh, Suvarna, Ulfendahl, M   +8 more
core   +1 more source

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity [PDF]

, 2009
The use of chemically synthesized short interfering RNAs (siRNAs) is currently the method of choice to manipulate gene expression in mammalian cell culture, yet improvements of siRNA design is expectably required for successful application in vivo ...
Laursen, Maria B., Bobkov, Georgii V., Herdewijn, Piet, Chattopadhyaya, Jyoti,, Hess, Simone, Van Aerschot, Arthur, Barman, Jharna,, Hansen, Thomas B., Barman, Jharna, Haas, Jens, Zhou, Chuanzheng,, Højland, Torben, Bramsen, Jesper B., Andree, Cordula, Srivastava, Puneet,, Hojland, Torben, Honcharenko, Dmytro,, Meyer, Thomas F., Kjems, Jørgen, Wenska, Malgorzata,, Zhou, Chuanzheng, Babu, B. Ravindra, Smicius, Romualdas, Srivastava, Puneet, Nielsen, Anne F., Odadžić, Dalibor, Müller, Elke, Wengel, Jesper, Bus, Claus, Engels, Joachim W. (Prof. Dr.), Honcharenko, Dmytro, Chattopadhyaya, Jyoti, Abramov, Mikhail, Langkjaer, Niels, Fava, Eugenio, Laursen, Maria B, Mikhailov, Sergey N., Langkjær, Niels, Engels, Joachim W., Wenska, Malgorzata, Zerial, Marino, Van, Aerschot A, Højland, T, Bramsen, JB, Hansen, TB, Laursen, MB, Bus, C, Babu, BR, Langkjaer, N, Nielsen, AF, Abramov, M   +50 more
core   +1 more source

siRNA-based depletion of select TurboID hits suggests a generalized role for PABC proteins in viral gene expression.

, 2023
(A) Representative western blots of siRNA-treated WT iSLK cell lysates at 48 h post reactivation showing the efficiency of XRN1, CASK, and PABPC1 depletion as well as levels of the representative late protein, K8.1, and early protein, ORF6.
Allison L. Didychuk (9344909), Dawei Liu (156201), Laura A. Murray-Nerger (15307232), Ileana M. Cristea (246789), Britt A. Glaunsinger (8423214), Chloe O. McCollum (9344915)   +5 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing

, 2010
We report that combining a DNA analog (2?F-ANA) with rigid RNA analogs [2?F-RNA and/or locked nucleic acid (LNA)] in siRNA duplexes can produce gene silencing agents with enhanced potency. The favored conformations of these two analogs are different, and
Alain, Tommy, Robert, Francis, Aishwarya, Veenu, Pelletier, Jerry, Deleavey, Glen F., Gewirtz, Alan M., Sonenberg, Nahum, Damha, Masad J., Kalota, Anna, Watts, Jonathan K.   +9 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A comparative study of cationic formulations for the delivery of siRNA and DNA [PDF]

, 2009
RNA interference (RNAi) provides a specific and efficient way to silence gene expression; therefore, it is an attractive tool to be used in basic research on gene function as well as gene therapy.
Kwok, N.P.A.
core