Results 51 to 60 of about 535,239 (304)

GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics

Nucleic Acid Therapeutics, 2018
Short-interfering RNA (siRNA)-induced RNAi responses have great potential to treat a wide variety of human diseases from cancer to pandemic viral outbreaks to Parkinson's Disease.
Aaron D Springer, S. Dowdy
semanticscholar   +1 more source

siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

Science Translational Medicine, 2020
Targeted siRNA nanoparticles can specifically inhibit pro-atherogenic macrophage pathways to combat atherosclerotic vascular disease. Perturbing plaque macrophages Macrophages in atherosclerotic lesions promote inflammation and plaque progression and are
Wei Tao, Arif Yurdagul, Na Kong, Wenliang Li, Xiaobo Wang, Amanda C. Doran, Chan Feng, Junqing Wang, M. Islam, O. Farokhzad, I. Tabas, Jinjun Shi   +11 more
semanticscholar   +1 more source

Dendrimers for siRNA Delivery [PDF]

Pharmaceuticals, 2013
Since the discovery of the “starburst polymer”, later renamed as dendrimer, this class of polymers has gained considerable attention for numerous biomedical applications, due mainly to the unique characteristics of this macromolecule, including its monodispersity, uniformity, and the presence of numerous functionalizable terminal groups.
Swati Biswas, Vladimir P. Torchilin
openaire   +3 more sources

Knocking down barriers: advances in siRNA delivery

Nature reviews. Drug discovery, 2009
In the 10 years that have passed since the Nobel prize-winning discovery of RNA interference (RNAi), billions of dollars have been invested in the therapeutic application of gene silencing in humans.
K. Whitehead, R. Langer, Daniel G. Anderson   +2 more
semanticscholar   +1 more source

Overcoming Barriers for siRNA Therapeutics: From Bench to Bedside

Pharmaceuticals, 2020
The RNA interference (RNAi) pathway possesses immense potential in silencing any gene in human cells. Small interfering RNA (siRNA) can efficiently trigger RNAi silencing of specific genes.
M. Sajid, Muhammad Moazzam, Shun Kato, Kayley Yeseom Cho, R. Tiwari   +4 more
semanticscholar   +1 more source

Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems

Biomolecules, 2019
Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate ...
Shima Tavakol, Milad Ashrafizadeh, Shuo Deng, Maryam Azarian, Asghar Abdoli, Mahsa Motavaf, Delaram Poormoghadam, Hashem Khanbabaei, Elham Ghasemipour Afshar, Ali Mandegary, Abbas Pardakhty, Celestial T. Yap, Reza Mohammadinejad, Alan Prem Kumar   +13 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Low energy vs. high energy depositional settings related sedimentary bodies in early Senonian rudist bearing carbonate shelves (central-southern Italy)

, 2001
Carannante Gabriele, Laviano A., Ruberti D., Simone Lucia, Sirna G., Sirna M., Tropeano M. Low energy vs. high energy depositional settings and related sedimentary bodies in early Senenian rudist bearing carbonate shelves (central-southern Italy).
SIRNA, Maurizio, LAVIANO A., CARANNANTE G, R. Graziano, SIRNA G, SIMONE, LUCIA, CARANNANTE G., Tropeano M., SIMONE L, CARANNANTE, GABRIELE, Sirna, M., Sirna M, Sirna, G., Laviano, A., GRAZIANO R., RUBERTI D., LAVIANO A, D. Ruberti, L. Simone, G. Sirna, SIRNA G., RUBERTI, Daniela, TROPEANO, MARCELLO, SIMONE L., SIRNA M., Ruberti, D., Tropeano, M., G. Carannante, LAVIANO, Angela   +28 more
core   +1 more source