Results 51 to 60 of about 382,657 (316)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Российский кардиологический журналPatients after heart transplantation (HT) are at very high risk for cardiovascular disease. Protocols for the management of heart recipients include the initiation of lipid-lowering therapy (LLT), regardless of sex, age and origin of heart failure. Given
M. A. Simonenko +3 more
doaj +1 more source
Genotyping and siRNA-Mediated Quorum Sensing Inhibition in Staphylococcus aureus: Exploring New Approaches for Treating Persistent Infections [PDF]
Journal of Bioscience and Applied ResearchEmersion of persistent Staphylococcus aureus requires original research and developmental planning. Repression of virulence genes might be a committed therapeutic approach in this regard. Gene-quenching with short interfering RNA (siRNA) is considered an
Tabark Qader, Munim Ali, Ali Alsakini
doaj +1 more source
PepFect6 Mediated SiRNA Delivery into Organotypic Cultures
, 2016 Gene silencing by small interfering RNA (SiRNA) is an attractive therapeutic approach for pathological disorders that targets a specific gene. However, its applications are limited, as naked RNA is rapidly degraded by RNases and is inadequately ...
Ulfendahl, Mats +8 more
core +1 more source
Design of double-walled carbon nanotubes for biomedical applications [PDF]
, 2012 Double-walled carbon nanotubes (DWNTs) prepared by catalytic chemical vapour deposition were functionalized in such a way that they were optimally designed as a nano-vector for the delivery of small interfering RNA (siRNA), which is of great interest for
Coley, Helen M. +19 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
siRNA-knockdown of MYO1C enhanced viability.
, 2016 (a) Immunoblot of MYO1C protein expression in MCF10A cells transfected with MYO1C-siRNA and negative control (scrambled siRNA) to the final concentration of 10nM at 24, 48, 72 and 96 hours post-transfection.
Kittichate Visuttijai (3204519) +10 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
siRNA-mediated knockdown of selected IGCs impairs GSC viability.
, 2017 A. Real-time qPCR analysis of IGC expression levels 24 hours after transfection of scrambled negative control siRNA (siScr) and individual siRNA candidates (1, 2, 3) for each IGC.
Robert C. Rostomily (650567) +9 more
core +1 more source