Results 21 to 30 of about 411,726 (313)

Addis Ababa/Finfinee: A Blueprint towards Twin-city Administration

Ethiopian Journal of the Social Sciences and Humanities, 2018
This article analyses the challenge of Addis Ababa´s double status – both as capital of Ethiopia and that of the Regional State of Oromia. It delves into the unresolved issue of the special interest of Oromia in Addis Ababa/Finfinnee.
Zelalem T. Sirna
doaj   +1 more source

Exosomes are natural carriers of exogenous siRNA to human cells in vitro [PDF]

, 2013
© 2013 Shtam et al. Background: Exosomes are nano-sized vesicles of endocytic origin that are involved in cell-to-cell communication including shuttle RNA, mainly mRNA and microRNA.
Varfolomeeva, EY, Kovalev, RA, Makarov, EM, Kil, YV, Filatov, MV, Shtam, TA, Elena Varfolomeeva, Roman A Kovalev, Tatyana A Shtam, Michael V Filatov, Evgeny M Makarov, Yury V Kil   +11 more
core   +1 more source

siRNA-mediated downregulation of HMB45 in differentiated ADSCs.

, 2021
siRNA resulted in the downregulation of HMB45 in undifferentiated ADSCs and differentiated ADSCs.
Yuri Ikeda (7360736), Toshio Hasegawa (695821), Masato Koike (209042), Mutsumi Yokota (9668895), Akino Wada (695823), Shigaku Ikeda (695826)   +5 more
core   +1 more source

Migrations de retour dans les Alpes italiennes : mobilités, « cittadinanza » et sentiment d’appartenance

Revue Européenne des Migrations Internationales, 2017
Migration studies often neglect return mobility or, on the contrary, the latter becomes the object of studies that do not consider the country where migrants settled, sometimes during years. Building on a critical understanding of “return”, this research
Blanchard Melissa, Sirna Francesca
doaj   +1 more source

Beyond ribose and phosphate: Selected nucleic acid modifications for structure–function investigations and therapeutic applications

Beilstein Journal of Organic Chemistry, 2021
Over the past 25 years, the acceleration of achievements in the development of oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the market for the treatment of various diseases. Oligonucleotides with alterations to their
Christopher Liczner, Kieran Duke, Gabrielle Juneau, Martin Egli, Christopher J. Wilds   +4 more
doaj   +1 more source

Electrotransfer of siRNA to Silence Enhanced Green Fluorescent Protein in Tumor Mediated by a High Intensity Pulsed Electromagnetic Field

Vaccines, 2020
The contactless high intensity pulsed electromagnetic field (HI-PEMF)-induced increase of cell membrane permeability is similar to conventional electroporation, with the important difference of inducing an electric field non-invasively by exposing a ...
Simona Kranjc Brezar, Matej Kranjc, Maja Čemažar, Simon Buček, Gregor Serša, Damijan Miklavčič   +5 more
doaj   +1 more source

MIL-101-NH₂-mediated nucleic acid delivery and gene silencing

上海师范大学学报. 自然科学版, 2021
Nucleic acids, including DNA and RNA, can participate in the regulation of gene expression in all organisms. However, those nucleic acid molecules are easily to be degraded. If they are directly administered orally or intravenously, their bioavailability
AI Yichun, YUAN Xuejiao, YU Yicheng, LYU Min, CHEN Nan   +4 more
doaj   +1 more source

Synthesis of Cationic and Ionizable Amphiphiles Based on Heminal Aminodiol as Potential siRNA Delivery Systems

Тонкие химические технологии, 2019
Research methods based on the use of RNA interference mechanisms are now included among the basic methods of molecular biology. Drugs based on siRNA are being developed for the treatment of cancer, infectious diseases and other pathologies that are ...
Z. G. Denieva, U. A. Budanova, Yu. L. Sebyakin   +2 more
doaj   +1 more source

Digital modeling by biomedical informatics analysis predicts suppression of COVID-19 infectivity via ‘targeting oligonucleotide-directed devolution’ [PDF]

Exploration of Digital Health Technologies
Aim: Genetic instability represents the hallmark of carcinogenesis. For cancer, the retinoblastoma (RB) gene defect allowing genetic instability was successfully exploited to eliminate cancer.
Frank-Un Hong, Miguel Marciano Castro, Klaus D. Linse   +2 more
doaj   +1 more source

Anti-Metastatic Effects on Melanoma via Intravenous Administration of Anti-NF-κB siRNA Complexed with Functional Peptide-Modified Nano-Micelles

Pharmaceutics, 2020
Controlling metastasis is an important strategy in cancer treatment. Nanotechnology and nucleic acids with novel modalities are promising regulators of cancer metastasis.
Hisako Ibaraki, Takanori Kanazawa, Minami Owada, Keiko Iwaya, Yuuki Takashima, Yasuo Seta   +5 more
doaj   +1 more source