Results 21 to 30 of about 382,657 (316)

Beyond ribose and phosphate: Selected nucleic acid modifications for structure–function investigations and therapeutic applications

Beilstein Journal of Organic Chemistry, 2021
Over the past 25 years, the acceleration of achievements in the development of oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the market for the treatment of various diseases. Oligonucleotides with alterations to their
Christopher Liczner, Kieran Duke, Gabrielle Juneau, Martin Egli, Christopher J. Wilds   +4 more
doaj   +1 more source

Electrotransfer of siRNA to Silence Enhanced Green Fluorescent Protein in Tumor Mediated by a High Intensity Pulsed Electromagnetic Field

Vaccines, 2020
The contactless high intensity pulsed electromagnetic field (HI-PEMF)-induced increase of cell membrane permeability is similar to conventional electroporation, with the important difference of inducing an electric field non-invasively by exposing a ...
Simona Kranjc Brezar, Matej Kranjc, Maja Čemažar, Simon Buček, Gregor Serša, Damijan Miklavčič   +5 more
doaj   +1 more source

MIL-101-NH₂-mediated nucleic acid delivery and gene silencing

上海师范大学学报. 自然科学版, 2021
Nucleic acids, including DNA and RNA, can participate in the regulation of gene expression in all organisms. However, those nucleic acid molecules are easily to be degraded. If they are directly administered orally or intravenously, their bioavailability
AI Yichun, YUAN Xuejiao, YU Yicheng, LYU Min, CHEN Nan   +4 more
doaj   +1 more source

Synthesis of Cationic and Ionizable Amphiphiles Based on Heminal Aminodiol as Potential siRNA Delivery Systems

Тонкие химические технологии, 2019
Research methods based on the use of RNA interference mechanisms are now included among the basic methods of molecular biology. Drugs based on siRNA are being developed for the treatment of cancer, infectious diseases and other pathologies that are ...
Z. G. Denieva, U. A. Budanova, Yu. L. Sebyakin   +2 more
doaj   +1 more source

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity [PDF]

, 2009
The use of chemically synthesized short interfering RNAs (siRNAs) is currently the method of choice to manipulate gene expression in mammalian cell culture, yet improvements of siRNA design is expectably required for successful application in vivo ...
Laursen, Maria B., Bobkov, Georgii V., Herdewijn, Piet, Chattopadhyaya, Jyoti,, Hess, Simone, Van Aerschot, Arthur, Barman, Jharna,, Hansen, Thomas B., Barman, Jharna, Haas, Jens, Zhou, Chuanzheng,, Højland, Torben, Bramsen, Jesper B., Andree, Cordula, Srivastava, Puneet,, Hojland, Torben, Honcharenko, Dmytro,, Meyer, Thomas F., Kjems, Jørgen, Kjems, Jorgen, Wenska, Malgorzata,, Zhou, Chuanzheng, Babu, B. Ravindra, Smicius, Romualdas, Srivastava, Puneet, Nielsen, Anne F., Odadžić, Dalibor, Müller, Elke, Wengel, Jesper, Bus, Claus, Engels, Joachim W. (Prof. Dr.), Honcharenko, Dmytro, Chattopadhyaya, Jyoti, Abramov, Mikhail, Langkjaer, Niels, Fava, Eugenio, Laursen, Maria B, Mikhailov, Sergey N., Langkjær, Niels, Engels, Joachim W., Wenska, Malgorzata, Aerschot, Arthur Van, Zerial, Marino   +42 more
core   +1 more source

Digital modeling by biomedical informatics analysis predicts suppression of COVID-19 infectivity via ‘targeting oligonucleotide-directed devolution’ [PDF]

Exploration of Digital Health Technologies
Aim: Genetic instability represents the hallmark of carcinogenesis. For cancer, the retinoblastoma (RB) gene defect allowing genetic instability was successfully exploited to eliminate cancer.
Frank-Un Hong, Miguel Marciano Castro, Klaus D. Linse   +2 more
doaj   +1 more source

Anti-Metastatic Effects on Melanoma via Intravenous Administration of Anti-NF-κB siRNA Complexed with Functional Peptide-Modified Nano-Micelles

Pharmaceutics, 2020
Controlling metastasis is an important strategy in cancer treatment. Nanotechnology and nucleic acids with novel modalities are promising regulators of cancer metastasis.
Hisako Ibaraki, Takanori Kanazawa, Minami Owada, Keiko Iwaya, Yuuki Takashima, Yasuo Seta   +5 more
doaj   +1 more source

siRNA-mediated downregulation of HMB45 in differentiated ADSCs.

, 2021
siRNA resulted in the downregulation of HMB45 in undifferentiated ADSCs and differentiated ADSCs.
Yuri Ikeda (7360736), Toshio Hasegawa (695821), Masato Koike (209042), Mutsumi Yokota (9668895), Akino Wada (695823), Shigaku Ikeda (695826)   +5 more
core   +1 more source

Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy

, 2007
The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Here we demonstrate cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer. The
Haitang Li, John Zaia, John Rossi, Jiehua Zhou, Shirley Li   +4 more
core   +1 more source

Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems

Biomolecules, 2019
Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate ...
Shima Tavakol, Milad Ashrafizadeh, Shuo Deng, Maryam Azarian, Asghar Abdoli, Mahsa Motavaf, Delaram Poormoghadam, Hashem Khanbabaei, Elham Ghasemipour Afshar, Ali Mandegary, Abbas Pardakhty, Celestial T. Yap, Reza Mohammadinejad, Alan Prem Kumar   +13 more
doaj   +1 more source