Results 41 to 50 of about 723,122 (201)
BioanalysisBackground: Antisense oligonucleotides (ASOs) have been conjugated to various moieties, such as peptides, antibodies or Fab regions of antibodies, to enhance their delivery to target tissues.
Di Jiang, Pei-Chuan Li, Long Yuan
semanticscholar +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
bioRxiv, 2019 The blood-brain barrier (BBB), hinders the distribution of therapeutics, intended for treatment of diseases of the brain. A twelve-amino acid peptide, termed MTfp, was derived from MTf, and retains the ability to cross the BBB intact and ferry cargo into
B. A. Eyford +17 more
semanticscholar +1 more source
, 2003 The synthesis of a peptide-PEG-oligonucleotide chimera is compared when starting from the peptide or from the oligonucleotide ...
BALLICO M. +9 more
core +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj +23 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Prostate patient‐derived organoids (PDOs) were established from TURP and biopsy specimens with >90% success and retain key features of their tissues of origin, making them functional avatars for antisense oligonucleotide (ASO) therapy . Transfecting single cells outside the Matrigel matrix and then reconstituting organoids overcomes the 3D delivery ...
Thi Thom Tran +15 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Recent advances in microfluidic technologies for microgel fabrication are critically reviewed, highlighting the capabilities and limitations of major microfluidic platforms and discussing how platform design, material selection, and crosslinking strategies influence microgel architecture and functionality. Current challenges and future opportunities in
Afshin Abrishamkar +6 more
wiley +1 more source
Total Stepwise Solid-Phase Synthesis of Oligonucleotide-(3‘→N)-Peptide Conjugates
, 2016 An efficient total stepwise solid-phase synthesis of oligonucleotide-(3‘→N)-peptide conjugates is described that makes use of either a controlled pore glass support or macroporous polystyrene beads.
Dmitry A. Stetsenko (1796035) +2 more
core +2 more sources
Synthesis of Peptide-plasmid Conjugate.
, 2015 (A) Scheme for oligonucleotide-polyR synthesis using click chemistry and incorporation into GFP reporter plasmid. (B) Reaction scheme for the coupling of Dibenzocyclooctyne (DBCO)-PEG4-maleimide to peptides using Michael-type addition, and the reaction ...
Yixin Zhang (173038) +5 more
core +1 more source