Results 21 to 30 of about 651,747 (238)

Dual miRNases for Triple Incision of miRNA Target: Design Concept and Catalytic Performance

Molecules, 2020
Irreversible destruction of disease-associated regulatory RNA sequences offers exciting opportunities for safe and powerful therapeutic interventions against human pathophysiology.
Olga Patutina, Daria Chiglintseva, Elena Bichenkova, Svetlana Gaponova, Nadezhda Mironova, Valentin Vlassov, Marina Zenkova   +6 more
doaj   +1 more source

Synthesis of Oligonucleotide–Peptide Conjugates for Biomedical and Technological Applications [PDF]

, 2011
Oligonucleotide-peptide conjugates have attracted considerable interest especially for biomedical uses. In the first part of this chapter, we describe protocols for the stepwise synthesis of oligonucleotides carrying peptide sequences at the 3'-end on a single support.
Anna, Aviñó, Santiago, Grijalvo, Sónia, Pérez-Rentero, Alejandra, Garibotti, Montserrat, Terrazas, Ramon, Eritja   +5 more
openaire   +2 more sources

Modified peptide-oligonucleotide conjugate

, 2023
The present invention relates to a modified peptide-oligonucleotide conjugates (POC) composed of a cell-penetrating peptide (CPP) conjugated to an antisense oligonucleotide.
Azevedo, Nuno Filipe, Wengel, Jesper Thagaard, Pereira, Sara Raquel do Souto, Santos, Rita Sobral Fernandes Machado dos, Guimarães, Nuno Miguel da Rocha, Moreira, Luis Miguel de Aquino   +5 more
core   +1 more source

Stepwise synthesis of oligonucleotide–peptide conjugates containing guanidinium and lipophilic groups in their 3′-termini [PDF]

Bioorganic & Medicinal Chemistry Letters, 2010
Two different series of oligonucleotide-peptide conjugates have been efficiently synthesized by stepwise solid-phase synthesis. First, oligonucleotides and oligonucleotide phosphorothioates containing polar groups at the 3'-termini, such as amine and guanidinium groups were prepared.
Grijalvo, Santiago, Terrazas Martínez, Montserrat, Aviñó Andrés, Anna, Eritja i Casadellà, Ramon   +3 more
openaire   +4 more sources

Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency

Molecular Therapy: Nucleic Acids, 2013
We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as B peptide) and muscle-targeting peptide (referred as MSP) motifs significantly improve the systemic exon-skipping activity of ...
HaiFang Yin, Prisca Boisguerin, Hong M Moulton, Corinne Betts, Yiqi Seow, Jordan Boutilier, Qingsong Wang, Anthony Walsh, Bernard Lebleu, Matthew JA Wood   +9 more
doaj   +1 more source

Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase

Molecules, 2019
Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and ...
Ian J. Huggins, Carlos A. Medina, Aaron D. Springer, Arjen van den Berg, Satish Jadhav, Xianshu Cui, Steven F. Dowdy   +6 more
doaj   +1 more source

Oligonucleotide-Peptide Conjugates: Solid-Phase Synthesis under Acidic Conditions and Use in ELISA Assays [PDF]

Molecules, 2012
Here we used solid-phase methods to prepare oligonucleotides carrying fibrin/ filaggrin citrullinated peptides. Post-synthetic conjugation protocols were successfully applied for the synthesis of oligonucleotides carrying small peptides. A stepwise protocol using acid treatment for the final deprotection allowed the preparation of polypyrimidine ...
Anna Aviñó, Maria José Gómara, Morteza Malakoutikhah, Isabel Haro, Ramon Eritja   +4 more
openaire   +4 more sources

Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model

Frontiers in Pharmacology, 2019
Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases ...
Olga A. Patutina, Svetlana K. Miroshnichenko, Nadezhda L. Mironova, Aleksandra V. Sen’kova, Elena V. Bichenkova, David J. Clarke, Valentin V. Vlassov, Marina A. Zenkova   +7 more
doaj   +1 more source

Optimizing Tissue-Specific Antisense Oligonucleotide–Peptide Conjugates

, 2012
Cell-targeting peptides which improve tissue-specific delivery of antisense oligonucleotides (AONs) are a new exciting "next-generation" potential AON therapy. New peptides are regularly developed which increase targeting and cell penetration for the AON treatment of mRNA misregulated diseases.
Betts, C, Hammond, S, Yin, H, Wood, M
openaire   +2 more sources

Method of expanded porphyrin-oligonucleotide conjugate synthesis [PDF]

, 1995
The invention is directed to a method of incorporating expanded porphyrins, and particularly of incorporating a sapphyrin or a texaphyrin, before, during, or after chemical synthesis of an oligomer to form an expanded porphyrin-oligonucleotide conjugate,
Magda, Darren, Iverson, Brent L., Sessler, Jonathan L., Crofts, Shaun P., Sansom, Petra I.   +4 more
core   +1 more source