Results 21 to 30 of about 723,122 (201)

A transferrin receptor 1-targeted PNA-peptide conjugate inhibits microRNA-21 expression in cardiac and other mouse tissues

bioRxiv, 2023
MicroRNAs (miRNAs) are implicated in the onset and progression of a variety of diseases. Modulating the expression of specific miRNAs is a possible option for therapeutic intervention.
Genwei Zhang, Sarah Antilla, Cheng-Xi Li, A. Loas, Thomas E. Nielsen, B. Pentelute   +5 more
semanticscholar   +1 more source

Peptide Conjugates of a 2′-O-Methoxyethyl Phosphorothioate Splice-Switching Oligonucleotide Show Increased Entrapment in Endosomes

ACS Omega, 2023
Antisense oligonucleotides (ASOs) are short, single-stranded nucleic acid molecules that alter gene expression. However, their transport into appropriate cellular compartments is a limiting factor in their potency.
Alyssa C. Hill, J. Becker, Daria Slominski, François Halloy, C. Søndergaard, Jacob Ravn, Jonathan Hall   +6 more
semanticscholar   +1 more source

Efficient Synthesis of 2’‐O‐Methoxyethyl Oligonucleotide‐Cationic Peptide Conjugates

ChemMedChem, 2021
Single‐stranded phosphorothioate (PS) oligonucleotide drugs have shown potential for the treatment of several rare diseases. However, a barrier to their widespread use is that they exhibit activity in only a narrow range of tissues. One way to circumvent
François Halloy, Alyssa C. Hill, Jonathan Hall   +2 more
semanticscholar   +1 more source

Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences

Molecules, 2021
RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are currently ...
Yaroslav Staroseletz, Svetlana Gaponova, Olga Patutina, Elena Bichenkova, Bahareh Amirloo, Thomas Heyman, Daria Chiglintseva, Marina Zenkova   +7 more
doaj   +1 more source

RNA-Peptide Conjugation through an Efficient Covalent Bond Formation

Applied Sciences, 2020
Many methods for modification of an oligonucleotide with a peptide have been developed to apply for the therapeutic and diagnostic applications or for the assembly of nanostructure.
Shun Nakano, Taiki Seko, Zhengxiao Zhang, Takashi Morii   +3 more
doaj   +1 more source

Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases

RNA Biology, 2022
RNA therapeutics comprise a diverse group of oligonucleotide-based drugs such as antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and short hairpin RNAs (shRNAs) that can be designed to selectively interact with drug targets currently ...
Anja Holm, Stine N. Hansen, Henrik Klitgaard, Sakari Kauppinen   +3 more
doaj   +1 more source

Exploiting Protected Maleimides to Modify Oligonucleotides, Peptides and Peptide Nucleic Acids

Molecules, 2015
This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids ...
Clément Paris, Omar Brun, Enrique Pedroso, Anna Grandas   +3 more
doaj   +1 more source

Dual miRNases for Triple Incision of miRNA Target: Design Concept and Catalytic Performance

Molecules, 2020
Irreversible destruction of disease-associated regulatory RNA sequences offers exciting opportunities for safe and powerful therapeutic interventions against human pathophysiology.
Olga Patutina, Daria Chiglintseva, Elena Bichenkova, Svetlana Gaponova, Nadezhda Mironova, Valentin Vlassov, Marina Zenkova   +6 more
doaj   +1 more source

Modified peptide-oligonucleotide conjugate

, 2023
The present invention relates to a modified peptide-oligonucleotide conjugates (POC) composed of a cell-penetrating peptide (CPP) conjugated to an antisense oligonucleotide.
Azevedo, Nuno Filipe, Wengel, Jesper Thagaard, Pereira, Sara Raquel do Souto, Santos, Rita Sobral Fernandes Machado dos, Guimarães, Nuno Miguel da Rocha, Moreira, Luis Miguel de Aquino   +5 more
core   +1 more source

Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency

Molecular Therapy: Nucleic Acids, 2013
We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as B peptide) and muscle-targeting peptide (referred as MSP) motifs significantly improve the systemic exon-skipping activity of ...
HaiFang Yin, Prisca Boisguerin, Hong M Moulton, Corinne Betts, Yiqi Seow, Jordan Boutilier, Qingsong Wang, Anthony Walsh, Bernard Lebleu, Matthew JA Wood   +9 more
doaj   +1 more source