Results 21 to 30 of about 20,124 (257)

Modified peptide-oligonucleotide conjugate

, 2023
The present invention relates to a modified peptide-oligonucleotide conjugates (POC) composed of a cell-penetrating peptide (CPP) conjugated to an antisense oligonucleotide.
Azevedo, Nuno Filipe, Wengel, Jesper Thagaard, Pereira, Sara Raquel do Souto, Santos, Rita Sobral Fernandes Machado dos, Guimarães, Nuno Miguel da Rocha, Moreira, Luis Miguel de Aquino   +5 more
core   +1 more source

Stepwise synthesis of oligonucleotide–peptide conjugates containing guanidinium and lipophilic groups in their 3′-termini [PDF]

Bioorganic & Medicinal Chemistry Letters, 2010
Two different series of oligonucleotide-peptide conjugates have been efficiently synthesized by stepwise solid-phase synthesis. First, oligonucleotides and oligonucleotide phosphorothioates containing polar groups at the 3'-termini, such as amine and guanidinium groups were prepared.
Grijalvo, Santiago, Terrazas Martínez, Montserrat, Aviñó Andrés, Anna, Eritja i Casadellà, Ramon   +3 more
openaire   +4 more sources

Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency

Molecular Therapy: Nucleic Acids, 2013
We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as B peptide) and muscle-targeting peptide (referred as MSP) motifs significantly improve the systemic exon-skipping activity of ...
HaiFang Yin, Prisca Boisguerin, Hong M Moulton, Corinne Betts, Yiqi Seow, Jordan Boutilier, Qingsong Wang, Anthony Walsh, Bernard Lebleu, Matthew JA Wood   +9 more
doaj   +1 more source

Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase

Molecules, 2019
Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and ...
Ian J. Huggins, Carlos A. Medina, Aaron D. Springer, Arjen van den Berg, Satish Jadhav, Xianshu Cui, Steven F. Dowdy   +6 more
doaj   +1 more source

Synthesis of OligonucleotidePeptide Conjugates Carrying the c‐myc Peptide Epitope as Recognition System [PDF]

Chemistry & Biodiversity, 2004
AbstractOligonucleotidepeptide conjugates 1–3 were prepared by sequential addition of the appropriate Boc‐protected amino acids, followed by nucleoside phosphoramidites in the same support. These molecules are designed to be used for triplex formation and for the directed assembly of nanomaterials. The structures of the desired oligonucleotidepeptide
Frieden, Miriam, Eritja Casadellà, Ramón, Aviñó, Anna, Tarrasón, Gema, Escorihuela, Marta, Piulats, Jaume   +5 more
openaire   +3 more sources

Oligonucleotide-Peptide Conjugates: Solid-Phase Synthesis under Acidic Conditions and Use in ELISA Assays [PDF]

Molecules, 2012
Here we used solid-phase methods to prepare oligonucleotides carrying fibrin/ filaggrin citrullinated peptides. Post-synthetic conjugation protocols were successfully applied for the synthesis of oligonucleotides carrying small peptides. A stepwise protocol using acid treatment for the final deprotection allowed the preparation of polypyrimidine ...
Anna Aviñó, Maria José Gómara, Morteza Malakoutikhah, Isabel Haro, Ramon Eritja   +4 more
openaire   +4 more sources

Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model

Frontiers in Pharmacology, 2019
Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases ...
Olga A. Patutina, Svetlana K. Miroshnichenko, Nadezhda L. Mironova, Aleksandra V. Sen’kova, Elena V. Bichenkova, David J. Clarke, Valentin V. Vlassov, Marina A. Zenkova   +7 more
doaj   +1 more source

Novel SPEA Superantigen Peptide Agonists and Peptide Agonist-TGFαL3 Conjugate. In Vitro Study of Their Growth-Inhibitory Effects for Targeted Cancer Immunotherapy

, 2023
Bacterial superantigens (SAgs) are effective T-cell stimulatory molecules that lead to massive cytokine production. Superantigens crosslink between MHC class II molecules on the Antigen Presenting Cells (APC) and TCR on T-cells.
Sayed, G., Bashraheel, S. S.
core   +1 more source

Optimizing Tissue-Specific Antisense Oligonucleotide–Peptide Conjugates

, 2012
Cell-targeting peptides which improve tissue-specific delivery of antisense oligonucleotides (AONs) are a new exciting "next-generation" potential AON therapy. New peptides are regularly developed which increase targeting and cell penetration for the AON treatment of mRNA misregulated diseases.
Betts, C, Hammond, S, Yin, H, Wood, M
openaire   +2 more sources

PNA-induced assembly of fluorescent proteins using DNA as a framework

, 2013
Controlled alignment of proteins on molecular frameworks requires the development of facile and orthogonal chemical approaches and molecular scaffolds. In this work, protein−PNA conjugates are brought forward as new chemical components allowing efficient
Gholami, Z., Brunsveld, L., Gholami, Z, Hanley, Q, Hanley, Q., Brunsweld, L, Brunsveld, L.; id_orcid   +6 more
core   +1 more source