Results 11 to 20 of about 723,122 (201)
Molecules, 2020 Radiotherapy, the most common therapy for the treatment of solid tumors, exerts its effects by inducing DNA damage. To fully understand the extent and nature of this damage, DNA models that mimic the in vivo situation should be utilized.
Paweł Wityk +3 more
doaj +3 more sources
New developments in the synthesis of oligonucleotide-peptide conjugates [PDF]
Nucleosides, Nucleotides and Nucleic Acids, 2007 The stability of oligodeoxynucleotides to trifluoroacetic acid is studied. Pyrimidine oligonucleotides were stable in the conditions used for the removal of t-butyl groups.
Ramon Eritja +2 more
exaly +3 more sources
Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation
Frontiers in Chemistry, 2021 Cell penetrating peptides (CPPs) are being increasingly used as efficient vectors for intracellular delivery of biologically active agents, such as therapeutic antisense oligonucleotides (ASOs).
Mohadeseh Dastpeyman +5 more
doaj +2 more sources
A Review of Protein- and Peptide-Based Chemical Conjugates: Past, Present, and Future
Pharmaceutics, 2023 Over the past few decades, the complexity of molecular entities being advanced for therapeutic purposes has continued to evolve. A main propellent fueling innovation is the perpetual mandate within the pharmaceutical industry to meet the needs of novel ...
Emily Holz +3 more
doaj +2 more sources
Fluorescence Imaging of Extracellular Potassium Ion Using Potassium Sensing Oligonucleotide
Frontiers in Chemistry, 2022 Potassium-sensing oligonucleotide, PSO, a conjugate of a quadruplex structure-forming oligonucleotide with a peptide incorporating a Förster Resonance Energy Transfer (FRET) chromophore pair, has been developed for fluorescent detection of potassium ion (
Shinobu Sato +8 more
doaj +2 more sources
Frontiers in Molecular Biosciences, 2021 The blood-brain barrier (BBB) hinders the distribution of therapeutics intended for treatment of neuroinflammation (NI) of the central nervous system. A twelve-amino acid peptide that transcytoses the BBB, termed MTfp, was chemically conjugated to siRNA ...
Brett A. Eyford +42 more
doaj +2 more sources
Targeted Delivery of a Splice-Switching Oligonucleotide by Cationic Polyplexes of RGD-Oligonucleotide Conjugate [PDF]
Molecular Pharmaceutics, 2012 Nanoparticle-based delivery has become an important strategy to advance therapeutic oligonucleotides into clinical reality. Delivery by nanocarriers can enhance access of oligonucleotides to their pharmacological targets within cells; preferably ...
Ming Xin, Lan Feng
semanticscholar +2 more sources
Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy [PDF]
Nucleic Acid Therapeutics, 2017 Splice-switching antisense oligonucleotides are emerging treatments for neuromuscular diseases, with several splice-switching oligonucleotides (SSOs) currently undergoing clinical trials such as for Duchenne muscular dystrophy (DMD) and spinal muscular ...
Fazel Shabanpoor +5 more
semanticscholar +2 more sources
Analytical Sciences, 2018 A peptide-oligonucleotide conjugate ( 1 ) was synthesized by the attachment of FAM, TAMRA, and biotin moieties to a telomere DNA sequence of 5'-TAG GGT TAG GGT TAG GGT TAG GG-3'.
Shinobu Sato +4 more
semanticscholar +2 more sources
Pharmaceutics, 2023 Currently, oligonucleotide therapy has emerged as a new paradigm in the treatment of human diseases. In many cases, however, therapeutic oligonucleotides cannot be used directly without modification.
Irina V. Varizhuk +6 more
doaj +1 more source