Results 11 to 20 of about 651,747 (238)

Synthesis of OligonucleotidePeptide Conjugates Carrying the c‐myc Peptide Epitope as Recognition System [PDF]

Chemistry & Biodiversity, 2004
AbstractOligonucleotidepeptide conjugates 1–3 were prepared by sequential addition of the appropriate Boc‐protected amino acids, followed by nucleoside phosphoramidites in the same support. These molecules are designed to be used for triplex formation and for the directed assembly of nanomaterials. The structures of the desired oligonucleotidepeptide
Frieden, Miriam, Eritja Casadellà, Ramón, Aviñó, Anna, Tarrasón, Gema, Escorihuela, Marta, Piulats, Jaume   +5 more
openaire   +5 more sources

Advances in antisense oligonucleotide development for target identification, validation, and as novel therapeutics [PDF]

, 2008
Antisense oligonucleotides (As-ODNs) are single stranded, synthetically prepared strands of deoxynucleotide sequences, usually 18–21 nucleotides in length, complementary to the mRNA sequence of the target gene.
Alirio J. Melendez, Mansoor, Moizza, Moizza Mansoor, Melendez, Alirio J.   +3 more
core   +8 more sources

A Nanomule Peptide Carrier Delivers siRNA Across the Intact Blood-Brain Barrier to Attenuate Ischemic Stroke

Frontiers in Molecular Biosciences, 2021
The blood-brain barrier (BBB) hinders the distribution of therapeutics intended for treatment of neuroinflammation (NI) of the central nervous system. A twelve-amino acid peptide that transcytoses the BBB, termed MTfp, was chemically conjugated to siRNA ...
Brett A. Eyford, Brett A. Eyford, Brett A. Eyford, Brett A. Eyford, Chaahat S. B. Singh, Chaahat S. B. Singh, Chaahat S. B. Singh, Chaahat S. B. Singh, Chaahat S. B. Singh, Thomas Abraham, Lonna Munro, Lonna Munro, Kyung Bok Choi, Kyung Bok Choi, Tracy Hill, Rhonda Hildebrandt, Ian Welch, Timothy Z. Vitalis, Reinhard Gabathuler, Reinhard Gabathuler, Jacob A. Gordon, Jacob A. Gordon, Hans Adomat, Hans Adomat, Emma S.T. Guns, Emma S.T. Guns, Chieh-Ju Lu, Chieh-Ju Lu, Chieh-Ju Lu, Chieh-Ju Lu, Cheryl G. Pfeifer, Cheryl G. Pfeifer, Cheryl G. Pfeifer, Cheryl G. Pfeifer, Mei Mei Tian, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies   +42 more
doaj   +1 more source

Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences

Molecules, 2021
RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are currently ...
Yaroslav Staroseletz, Svetlana Gaponova, Olga Patutina, Elena Bichenkova, Bahareh Amirloo, Thomas Heyman, Daria Chiglintseva, Marina Zenkova   +7 more
doaj   +1 more source

Oligonucleotide-templated reactions based on Peptide Nucleic Acid (PNA) probes: Concept and biomedical applications

, 2014
Sensing technologies based on Peptide Nucleic Acids (PNAs) and oligonucleotide-templated chemistry are perfectly suited for biomedical applications (e.g., diagnosis, prognosis and stratification of diseases) and could compete well with more traditional ...
Youngeun Choi (5470667), Gavin Metcalf (18566539), Mazen Haj Sleiman (18566542), Douglas Vair-Turnbull (18566545), Sylvain Ladame (1898404)   +4 more
core   +5 more sources

RNA-Peptide Conjugation through an Efficient Covalent Bond Formation

Applied Sciences, 2020
Many methods for modification of an oligonucleotide with a peptide have been developed to apply for the therapeutic and diagnostic applications or for the assembly of nanostructure.
Shun Nakano, Taiki Seko, Zhengxiao Zhang, Takashi Morii   +3 more
doaj   +1 more source

Antisense Inhibition of Human Telomerase by Phosphorothioate Oligonucleotide-Peptide Conjugates [PDF]

Nucleic Acids Symposium Series, 2008
Oligonucleotides can be covalently linked to peptides composed of any sequence of amino acids by SPFC. The peptides incorporated into the conjugates include nuclear localizing signals (NLS), nuclear export signals (NES), membrane fusion domain of some viral proteins and some designed peptides with amphipathic character.
Irmina, Diala, Satoshi, Murao, Masayuki, Fujii   +2 more
openaire   +2 more sources

Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases

RNA Biology, 2022
RNA therapeutics comprise a diverse group of oligonucleotide-based drugs such as antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and short hairpin RNAs (shRNAs) that can be designed to selectively interact with drug targets currently ...
Anja Holm, Stine N. Hansen, Henrik Klitgaard, Sakari Kauppinen   +3 more
doaj   +1 more source

Peptide catalyzed conjugate addition reactions of aldehydes to nitroolefins [PDF]

, 2013
In this thesis mechanistic investigations into the peptide catalyzed conjugate addition reaction between aldehydes and nitroolefins are described.
Duschmalé, Jörg
core   +1 more source

Exploiting Protected Maleimides to Modify Oligonucleotides, Peptides and Peptide Nucleic Acids

Molecules, 2015
This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids ...
Clément Paris, Omar Brun, Enrique Pedroso, Anna Grandas   +3 more
doaj   +1 more source