New developments in the synthesis of oligonucleotide-peptide conjugates [PDF]
Nucleosides, Nucleotides & Nucleic Acids, 2007 The stability of oligodeoxynucleotides to trifluoroacetic acid is studied. Pyrimidine oligonucleotides were stable in the conditions used for the removal of t-butyl groups.
Eritja Casadellà, Ramón +15 more
core +5 more sources
Russian Journal of Bioorganic Chemistry, 2019 : Nowadays, application of miRNases—artificial ribonucleases aimed at degradation of noncoding RNAs, in particular, miRNAs—represents one of the novel experimental approaches to inhibit tumorigenesis.
Patutina, O. A. +5 more
core +2 more sources
IGF1R-targeted delivery of a bridged nucleic acid oligonucleotide-peptide conjugate for microRNA-21 inhibition in triple-negative breast cancer. [PDF]
NAR CancerAbstract Triple-negative breast cancer (TNBC), defined by the absence of ER, PR, and Her2, impacts over 46 000 U.S. women annually, disproportionately affecting minority ethnic groups and individuals with BRCA mutations. Despite advancements such as PARP inhibitors, TNBC remains highly aggressive, with frequent recurrences and a 50 ...
Jin Y +3 more
europepmc +5 more sources
Antisense Inhibition of Human Telomerase by Phosphorothioate Oligonucleotide-Peptide Conjugates [PDF]
Nucleic Acids Symposium Series, 2008 Oligonucleotides can be covalently linked to peptides composed of any sequence of amino acids by SPFC. The peptides incorporated into the conjugates include nuclear localizing signals (NLS), nuclear export signals (NES), membrane fusion domain of some viral proteins and some designed peptides with amphipathic character.
Irmina, Diala +2 more
openaire +2 more sources
Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases
RNA Biology, 2022 RNA therapeutics comprise a diverse group of oligonucleotide-based drugs such as antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and short hairpin RNAs (shRNAs) that can be designed to selectively interact with drug targets currently ...
Anja Holm +3 more
doaj +1 more source
Peptide catalyzed conjugate addition reactions of aldehydes to nitroolefins [PDF]
, 2013 In this thesis mechanistic investigations into the peptide catalyzed conjugate addition reaction between aldehydes and nitroolefins are described.
Duschmalé, Jörg
core +1 more source
International Journal of Molecular Sciences, 2022 Oligonucleotide–peptide conjugates (OPCs) are a promising class of biologically active compounds with proven potential for improving nucleic acid therapeutics. OPCs are commonly recognized as an efficient instrument to enhance the cellular delivery of therapeutic nucleic acids.
Vladimir B. Tsvetkov +7 more
openaire +2 more sources
Dual miRNases for Triple Incision of miRNA Target: Design Concept and Catalytic Performance
Molecules, 2020 Irreversible destruction of disease-associated regulatory RNA sequences offers exciting opportunities for safe and powerful therapeutic interventions against human pathophysiology.
Olga Patutina +6 more
doaj +1 more source
Exploiting Protected Maleimides to Modify Oligonucleotides, Peptides and Peptide Nucleic Acids
Molecules, 2015 This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids ...
Clément Paris +3 more
doaj +1 more source
Synthesis of Oligonucleotide–Peptide Conjugates for Biomedical and Technological Applications [PDF]
, 2011 Oligonucleotide-peptide conjugates have attracted considerable interest especially for biomedical uses. In the first part of this chapter, we describe protocols for the stepwise synthesis of oligonucleotides carrying peptide sequences at the 3'-end on a single support.
Aviñó, Anna +5 more
openaire +3 more sources