Results 1 to 10 of about 32,953 (312)
Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity. [PDF]
PLoS ONE, 2013 G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome.
Rosalba Perrone +7 more
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Major G-Quadruplex Form of HIV-1 LTR Reveals a (3 + 1) Folding Topology Containing a Stem-Loop [PDF]
Journal of the American Chemical Society, 2018 Nucleic acids can form noncanonical four-stranded structures called G-quadruplexes. G-quadruplex-forming sequences are found in several genomes including human and viruses.
Brahim Heddi +2 more
exaly +4 more sources
G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]
Nucleic Acids Research, 2018 G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in ...
Richter, Sara N, Ruggiero, Emanuela
core +4 more sources
Microbiology Spectrum, 2022 Human enteroviruses cause many diseases; however, there is no specific therapeutic drug. G-quadruplex is an atypical secondary structure formed in the guanine rich region of DNA or RNA, which can exist in the viral genome.
Lu Lv, Leiliang Zhang
doaj +3 more sources
G-Quadruplexes and Their Ligands: Biophysical Methods to Unravel G-Quadruplex/Ligand Interactions [PDF]
Pharmaceuticals, 2021 Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of approaches that assess the binding mode and nature of the interactions between G4 forming sequences and their putative ligands. The experimental approaches used to characterize G4/ligand interactions can be categorized into structure-based methods (circular ...
Tiago Santos +3 more
openaire +4 more sources
iScience, 2021 Summary: G-quadruplex structures are associated with various biological activities, while in vivo evidence is essential to confirm the formation of G-quadruplexes inside cells.
Zhen Yu +2 more
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iScience, 2022 Summary: DNA G-quadruplex is a non-canonical secondary structure that could epigenetically regulate gene expression. To investigate the regulating role of G-quadruplex, we devised an integrating method to perform the algorithm profiling and genome-wide ...
Xiaolin Wang +10 more
doaj +1 more source
G-Quadruplexes in Human Telomere: Structures, Properties, and Applications
Molecules, 2023 G-quadruplexes, intricate four-stranded structures composed of G-tetrads formed by four guanine bases, are prevalent in both DNA and RNA. Notably, these structures play pivotal roles in human telomeres, contributing to essential cellular functions ...
Yan Xu, Makoto Komiyama
doaj +1 more source
G-Quadruplexes in the Archaea Domain [PDF]
Biomolecules, 2020 The importance of unusual DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, G-quadruplexes (G4s) have gained in popularity during the last decade, and their presence and functional relevance at the DNA and RNA level has been demonstrated in a number of viral, bacterial ...
Václav Brázda +13 more
openaire +6 more sources
Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2023 Determination of G-quadruplex formation in DNA is required for the design of small molecules (drugs) targeting G-quadruplex. In previous studies, we used the fluorescent protein RHAU53-CFP capable of recognizing parallel G-quadruplex structures through a
Trương Thị Tinh Tươm +3 more
doaj +1 more source