Results 1 to 10 of about 11,711,774 (302)

Exclusion of RNA-binding domains from G-quadruplex condensates by G-quadruplex ligands [PDF]

RSC Chemical Biology
Biomolecular liquid–liquid phase separation, which forms droplets in living cells, plays a crucial role in the regulation of gene expression. Dysfunction of liquid–liquid phase separation leads to aberrant aggregates that sequester RNA-binding proteins ...
Yoshiki Hashimoto, Ryosuke Suzuki, Mizuho Aya, Nagisa Takamiya, Mitsuki Tsuruta, Takeru Torii, Toshiyuki Goto, Keiko Kawauchi, Daisuke Miyoshi   +8 more
doaj   +2 more sources

AGAPE (Computational G‑Quadruplex Stabilization Prediction): The First Machine Learning Workflow for G‑Quadruplex Stabilization Prediction [PDF]

ACS Omega
Luisa D’Anna, Salvatore Contino, Rosalinda Marinello, Julie Fares, Giada De Simone, Antonio Monari, Florent Barbault, Giampaolo Barone, Alessio Terenzi, Ugo Perricone   +9 more
doaj   +2 more sources

G-quadruplex targeting chemical nucleases as a nonperturbative tool for analysis of cellular G-quadruplex DNA

iScience, 2021
Summary: G-quadruplex structures are associated with various biological activities, while in vivo evidence is essential to confirm the formation of G-quadruplexes inside cells.
Zhen Yu, Amber L. Hendricks, James A. Cowan   +2 more
doaj   +1 more source

Genomic G-quadruplex folding triggers a cytokine-mediated inflammatory feedback loop to aggravate inflammatory diseases

iScience, 2022
Summary: DNA G-quadruplex is a non-canonical secondary structure that could epigenetically regulate gene expression. To investigate the regulating role of G-quadruplex, we devised an integrating method to perform the algorithm profiling and genome-wide ...
Xiaolin Wang, Shunlun Chen, Zhuoyang Zhao, Fan Chen, Yuming Huang, Xingyu Guo, Linchuan Lei, Wantao Wang, Yanxin Luo, Huichuan Yu, Jianru Wang   +10 more
doaj   +1 more source

G-Quadruplexes in Human Telomere: Structures, Properties, and Applications

Molecules, 2023
G-quadruplexes, intricate four-stranded structures composed of G-tetrads formed by four guanine bases, are prevalent in both DNA and RNA. Notably, these structures play pivotal roles in human telomeres, contributing to essential cellular functions ...
Yan Xu, Makoto Komiyama
doaj   +1 more source

Evaluating RHAU140-CFP molecule for specific recognition of parallel DNA G-Quadruplex by the fluorescence spectrophotometer

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2023
Determination of G-quadruplex formation in DNA is required for the design of small molecules (drugs) targeting G-quadruplex. In previous studies, we used the fluorescent protein RHAU53-CFP capable of recognizing parallel G-quadruplex structures through a
Trương Thị Tinh Tươm, Nguyễn Viết Chánh, Phan Thị Phượng Trang, Đặng Thanh Dũng   +3 more
doaj   +1 more source

Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids

Pharmaceuticals, 2021
The role of G-quadruplexes in human cancers is increasingly well-defined. Accordingly, G-quadruplexes can be suitable drug targets and many small molecules have been identified to date as G-quadruplex binders, some using computer-based design methods and
Stephen Neidle
doaj   +1 more source

GW-2974 and SCH-442416 modulators of tyrosine kinase and adenosine receptors can also stabilize human telomeric G-quadruplex DNA.

PLoS ONE, 2022
GW-2974 is a potent tyrosine kinase receptor inhibitor while SCH-442416 is a potent adenosine receptors' antagonist with high selectivity towards human adenosine A2A receptor over other adenosine receptors. The two compounds were reported to possess anti-
Alaa A Salem, Ismail A El Haty, Mohammad A Ghattas   +2 more
doaj   +3 more sources

Structural insights and shedding light on preferential interactions of dietary flavonoids with G-quadruplex DNA structures: A new horizon

Heliyon, 2023
G-quadruplex, a structurally unique structure in nucleic acids present all throughout the human genome, has sparked great attention in therapeutic investigations. Targeting G-quadruplex structure is a new strategy for the drug development. Flavonoids are
Sagar Bag, Mangal Deep Burman, Sudipta Bhowmik   +2 more
doaj   +1 more source

Binding-Induced Diversity of a Human Telomeric G-Quadruplex Stability Phase Space

Pharmaceuticals, 2022
The structural polymorphism of G-quadruplex nucleic acids is an important factor in their recognition by proteins and small-molecule ligands. However, it is not clear why the binding of several ligands alters G-quadruplex topology.
Domen Oblak, San Hadži, Črtomir Podlipnik, Jurij Lah   +3 more
doaj   +1 more source