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Microbiology Spectrum, 2022 Human enteroviruses cause many diseases; however, there is no specific therapeutic drug. G-quadruplex is an atypical secondary structure formed in the guanine rich region of DNA or RNA, which can exist in the viral genome.
Lu Lv, Leiliang Zhang
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AGAPE (Computational G‑Quadruplex Stabilization Prediction): The First Machine Learning Workflow for G‑Quadruplex Stabilization Prediction [PDF]
ACS OmegaLuisa D’Anna +9 more
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iScience, 2021 Summary: G-quadruplex structures are associated with various biological activities, while in vivo evidence is essential to confirm the formation of G-quadruplexes inside cells.
Zhen Yu +2 more
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iScience, 2022 Summary: DNA G-quadruplex is a non-canonical secondary structure that could epigenetically regulate gene expression. To investigate the regulating role of G-quadruplex, we devised an integrating method to perform the algorithm profiling and genome-wide ...
Xiaolin Wang +10 more
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G-Quadruplexes in Human Telomere: Structures, Properties, and Applications
Molecules, 2023 G-quadruplexes, intricate four-stranded structures composed of G-tetrads formed by four guanine bases, are prevalent in both DNA and RNA. Notably, these structures play pivotal roles in human telomeres, contributing to essential cellular functions ...
Yan Xu, Makoto Komiyama
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Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2023 Determination of G-quadruplex formation in DNA is required for the design of small molecules (drugs) targeting G-quadruplex. In previous studies, we used the fluorescent protein RHAU53-CFP capable of recognizing parallel G-quadruplex structures through a
Trương Thị Tinh Tươm +3 more
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Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids
Pharmaceuticals, 2021 The role of G-quadruplexes in human cancers is increasingly well-defined. Accordingly, G-quadruplexes can be suitable drug targets and many small molecules have been identified to date as G-quadruplex binders, some using computer-based design methods and
Stephen Neidle
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PLoS ONE, 2022 GW-2974 is a potent tyrosine kinase receptor inhibitor while SCH-442416 is a potent adenosine receptors' antagonist with high selectivity towards human adenosine A2A receptor over other adenosine receptors. The two compounds were reported to possess anti-
Alaa A Salem +2 more
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Heliyon, 2023 G-quadruplex, a structurally unique structure in nucleic acids present all throughout the human genome, has sparked great attention in therapeutic investigations. Targeting G-quadruplex structure is a new strategy for the drug development. Flavonoids are
Sagar Bag +2 more
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Binding-Induced Diversity of a Human Telomeric G-Quadruplex Stability Phase Space
Pharmaceuticals, 2022 The structural polymorphism of G-quadruplex nucleic acids is an important factor in their recognition by proteins and small-molecule ligands. However, it is not clear why the binding of several ligands alters G-quadruplex topology.
Domen Oblak +3 more
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