Electrochemical and AFM Characterization of G-Quadruplex Electrochemical Biosensors and Applications
Journal of Nucleic Acids, 2018 Guanine-rich DNA sequences are able to form G-quadruplexes, being involved in important biological processes and representing smart self-assembling nanomaterials that are increasingly used in DNA nanotechnology and biosensor technology.
Ana-Maria Chiorcea-Paquim +2 more
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Chiral metallohelices enantioselectively target hybrid human telomeric G-quadruplex DNA [PDF]
, 2017 The design and synthesis of metal complexes that can specifically target DNA secondary structure has attracted considerable attention. Chiral metallosupramolecular complexes (e.g.
Howson, Suzanne E. +6 more
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Multimerization rules for G-quadruplexes [PDF]
Nucleic Acids Research, 2017 G-quadruplexes can multimerize under certain conditions, but the sequence requirements of such structures are not well understood. In this study, we investigated the ability of all possible variants of the central tetrad in a monomeric, parallel-strand G-quadruplex to form higher-order structures.
Kolesnikova, S. (Sofia) +4 more
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Synthesis of copper (II) porphyrin complexes and their interaction with c-myc G-quadruplex DNA
Journal of Holistic Integrative Pharmacy, 2021 Objective: To synthesize copper (II) porphyrin complexes and study their interactions with c-myc G-quadruplex DNA. Methods: The 5-p-hydroxyphenyl-10, 15, 20-tris (p-methoxyphenyl) copper (II) porphyrin complex [p-HTMOPPCu (II)] was synthesized by the ...
Kunxian YANG +7 more
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A Catalytic and Selective Scissoring Molecular Tool for Quadruplex Nucleic Acids [PDF]
, 2018 A copper complex embedded in the structure of a water-soluble naphthalene diimide has been designed to bind and cleave G-quadruplex DNA. We describe the properties of this ligand, including its catalytic activity in the generation of ROS.
Amendola, Valeria +10 more
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G-Quadruplexes Involving Both Strands of Genomic DNA Are Highly Abundant and Colocalize with Functional Sites in the Human Genome. [PDF]
PLoS ONE, 2016 The G-quadruplex is a non-canonical DNA structure biologically significant in DNA replication, transcription and telomere stability. To date, only G4s with all guanines originating from the same strand of DNA have been considered in the context of the ...
Andrzej S Kudlicki
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Conformational profiling of a G-rich sequence within the c-KIT promoter [PDF]
, 2017 G-quadruplexes (G4) within oncogene promoters are considered to be promising anticancer targets. However, often they undergo complex structural rearrangements that preclude a precise description of the optimal target.
Chaires, Jonathan B +4 more
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Human Telomeric G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2017 G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures, and the human telomeric DNA G-quadruplexes are considered attractive targets for anticancer drugs.
Clement, Lin, Danzhou, Yang
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The Interaction of Cyclic Naphthalene Diimide with G-Quadruplex under Molecular Crowding Condition
Molecules, 2020 G-quadruplex specific targeting molecules, also termed as G4 ligands, are attracting increasing attention for their ability to recognize and stabilize G-quadruplex and high potentiality for biological regulation.
Tingting Zou +6 more
doaj +1 more source
G-quadruplex formation of FXYD1 pre-mRNA indicates the possiblity of regulating expression of its protein product [PDF]
, 2014 G-quadruplexes are higher-order nucleic acid structures formed of square-planar arrangements of four guanine bases held together by Hoogsteen-type hydrogen bonds. Stacks of guanine tetrads are stabilised by intercalating potassium ions. FXYD1 encodes for
Baydoun, A. R. +2 more
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