Results 31 to 40 of about 13,927,214 (311)
Re-evaluation of G-quadruplex propensity with G4Hunter
Nucleic Acids Research, 2016 Critical evidence for the biological relevance of G-quadruplexes (G4) has recently been obtained in seminal studies performed in a variety of organisms.
Amina Bedrat, L. Lacroix, J. Mergny
semanticscholar +1 more source
On the Road to Fight Cancer: The Potential of G-Quadruplex Ligands as Novel Therapeutic Agents
International Journal of Molecular Sciences, 2021 Nucleic acid sequences able to adopt a G-quadruplex conformation are overrepresented within the human genome. This evidence strongly suggests that these genomic regions have been evolutionary selected to play a pivotal role in several aspects of cell ...
Irene Alessandrini +3 more
semanticscholar +1 more source
Molecules, 2013 Pyridyl polyoxazoles are 24-membered macrocyclic lactams comprised of a pyridine, four oxazoles and a phenyl ring. A derivative having a 2-(dimethylamino)ethyl chain attached to the 5-position of the phenyl ring was recently identified as a selective G ...
Joseph E. Rice +7 more
doaj +1 more source
DNA secondary structures: stability and function of G-quadruplex structures
Nature reviews genetics, 2012 In addition to the canonical double helix, DNA can fold into various other inter- and intramolecular secondary structures. Although many such structures were long thought to be in vitro artefacts, bioinformatics demonstrates that DNA sequences capable of
Matthew L. Bochman +2 more
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GNG Motifs Can Replace a GGG Stretch during G-Quadruplex Formation in a Context Dependent Manner. [PDF]
PLoS ONE, 2016 G-quadruplexes are one of the most commonly studied non-B DNA structures. Generally, these structures are formed using a minimum of 4, three guanine tracts, with connecting loops ranging from one to seven. Recent studies have reported deviation from this
Kohal Das +2 more
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Replication of G Quadruplex DNA [PDF]
Genes, 2019 A cursory look at any textbook image of DNA replication might suggest that the complex machine that is the replisome runs smoothly along the chromosomal DNA. However, many DNA sequences can adopt non-B form secondary structures and these have the potential to impede progression of the replisome.
Leticia Koch Lerner, Julian E. Sale
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Electrochemical and AFM Characterization of G-Quadruplex Electrochemical Biosensors and Applications
Journal of Nucleic Acids, 2018 Guanine-rich DNA sequences are able to form G-quadruplexes, being involved in important biological processes and representing smart self-assembling nanomaterials that are increasingly used in DNA nanotechnology and biosensor technology.
Ana-Maria Chiorcea-Paquim +2 more
doaj +1 more source
Exclusion of RNA-binding domains from G-quadruplex condensates by G-quadruplex ligands [PDF]
RSC Chemical BiologyBiomolecular liquid–liquid phase separation, which forms droplets in living cells, plays a crucial role in the regulation of gene expression. Dysfunction of liquid–liquid phase separation leads to aberrant aggregates that sequester RNA-binding proteins ...
Yoshiki Hashimoto +8 more
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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Nature Communications, 2017 G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in different cellular processes. Targeting G-quadruplex DNAs for cancer treatment is a very promising prospect.
Hong Xu +38 more
semanticscholar +1 more source
Multimerization rules for G-quadruplexes [PDF]
Nucleic Acids Research, 2017 G-quadruplexes can multimerize under certain conditions, but the sequence requirements of such structures are not well understood. In this study, we investigated the ability of all possible variants of the central tetrad in a monomeric, parallel-strand G-quadruplex to form higher-order structures.
Kolesnikova, S. (Sofia) +4 more
openaire +3 more sources