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Accounts of Chemical Research, 2022 CONSPECTUS: DNA G-quadruplex secondary structures formed in guanine-rich human telomeres and oncogene promoters are functionally important and have emerged as a promising new class of cancer-specific drug targets. These globular intramolecular structures
Luying Chen +3 more
semanticscholar +1 more source
Molecules, 2023 The naphthalene diimide compound QN-302, designed to bind to G-quadruplex DNA sequences within the promoter regions of cancer-related genes, has high anti-proliferative activity in pancreatic cancer cell lines and anti-tumor activity in several ...
Ahmed A. Ahmed +10 more
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ALU non-B-DNA conformations, flipons, binary codes and evolution [PDF]
Royal Society Open Science, 2020 ALUs contribute to genetic diversity by altering DNA's linear sequence through retrotransposition, recombination and repair. ALUs also have the potential to form alternative non-B-DNA conformations such as Z-DNA, triplexes and quadruplexes that alter the
Alan Herbert
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Frontiers in Microbiology, 2023 The genus Bartonella includes a group of species that are associated with a wide range of mammalian species, including human. It is challenging to detect all Bartonella species using a single molecular target due to its high genetic diversity.
Ying Bai +3 more
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iScience, 2021 Summary: G-quadruplex structures are associated with various biological activities, while in vivo evidence is essential to confirm the formation of G-quadruplexes inside cells.
Zhen Yu +2 more
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RNA G-quadruplex structure contributes to cold adaptation in plants
bioRxiv, 2022 Nucleotide composition is suggested to infer gene functionality and ecological adaptation of species to distinct environments. However, the underlying biological function of nucleotide composition dictating environmental adaptations is largely unknown ...
Xiaofei Yang +9 more
semanticscholar +1 more source
Major Achievements in the Design of Quadruplex-Interactive Small Molecules
Pharmaceuticals, 2022 Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic acids have great potential as selective drugs or as tools in drug target discovery programs, or even in the development of nanodevices for medical diagnosis. Hundreds
E. Mendes +4 more
semanticscholar +1 more source
Frontiers in Chemistry, 2020 i-Motifs are four-stranded DNA structures formed from sequences rich in cytosine, held together by hemi-protonated cytosine-cytosine base pairs. These structures have been utilized extensively as pH-switches in DNA-based nanotechnology.
Mahmoud A. S. Abdelhamid +3 more
doaj +1 more source
Multistep mechanism of G-quadruplex resolution during DNA replication
Science Advances, 2021 DNA helicases DHX36 and FANCJ constitute a previously unknown pathway that resolves G-quadruplex structures during DNA replication.
Koichi Sato +4 more
semanticscholar +1 more source
G-quadruplexes and helicases [PDF]
Nucleic Acids Research, 2016 Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as 'knots' within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures.
Mendoza, Oscar +4 more
openaire +3 more sources