Results 1 to 10 of about 9,085,971 (219)

Characterization of G-Quadruplexes in Enterovirus A71 Genome and Their Interaction with G-Quadruplex Ligands

Microbiology Spectrum, 2022
Human enteroviruses cause many diseases; however, there is no specific therapeutic drug. G-quadruplex is an atypical secondary structure formed in the guanine rich region of DNA or RNA, which can exist in the viral genome.
Lu Lv, Leiliang Zhang
doaj   +3 more sources

Analysis of G-quadruplex forming sequences in podocytes-marker genes and their potential roles in inherited glomerular diseases

Heliyon, 2023
Nephrotic Syndrome is the most widespread pediatric kidney disorder. Genetic alterations in podocyte genes are thought to be responsible for the disease. G-quadruplexes are non-conventional guanine-rich DNA and RNA structures, which are commonly found in
Mona Saad, Cybel Mehawej, Wissam H. Faour   +2 more
doaj   +1 more source

A Small Ligand That Selectively Binds to the G-quadruplex at the Human Vascular Endothelial Growth Factor Internal Ribosomal Entry Site and Represses the Translation

Frontiers in Chemistry, 2021
G-quadruplexes are believed to have important biological functions, so many small molecules have been screened or developed for targeting G-quadruplexes.
Xiao-Xia Hu, Xiao-Xia Hu, Sheng-Quan Wang, Shi-Quan Gan, Lei Liu, Ming-Qing Zhong, Meng-Hao Jia, Fei Jiang, Yan Xu, Chao-Da Xiao, Chao-Da Xiao, Xiang-Chun Shen, Xiang-Chun Shen   +12 more
doaj   +1 more source

Insights into the Small Molecule Targeting of Biologically Relevant G-Quadruplexes: An Overview of NMR and Crystal Structures

Pharmaceutics, 2022
G-quadruplexes turned out to be important targets for the development of novel targeted anticancer/antiviral therapies. More than 3000 G-quadruplex small-molecule ligands have been described, with most of them exerting anticancer/antiviral activity by ...
Andrea Criscuolo, Ettore Napolitano, Claudia Riccardi, Domenica Musumeci, Chiara Platella, Daniela Montesarchio   +5 more
doaj   +1 more source

Pressure Perturbation Studies of Noncanonical Viral Nucleic Acid Structures

Biology, 2021
G-quadruplexes are noncanonical structures formed by guanine-rich sequences of the genome. They are found in crucial loci of the human genome, they take part in the regulation of important processes like cell proliferation and cell death.
Judit Somkuti, Orsolya Réka Molnár, Anna Grád, László Smeller   +3 more
doaj   +1 more source

Helquat dyes targeting G-quadruplexes as a new class of anti-HIV-1 inhibitors

Scientific Reports, 2023
The secondary structure of nucleic acids containing quartets of guanines, termed G-quadruplexes, is known to regulate the transcription of many genes.
Marcela Pávová, Paul Eduardo Reyes-Gutiérrez, Jaroslav Kozák, Juraj Dobiaš, Yevgen Yurenko, Martin Lepšík, Filip Teplý, Jan Weber   +7 more
doaj   +1 more source

Contrasting roles for G-quadruplexes in regulating human Bcl-2 and virus homologues KSHV KS-Bcl-2 and EBV BHRF1

Scientific Reports, 2022
Herpesviruses are known to acquire several genes from their hosts during evolution. We found that a significant proportion of virus homologues encoded by HSV-1, HSV-2, EBV and KSHV and their human counterparts contain G-quadruplex motifs in their ...
Shivani Kumar, Chitteti Ramamurthy, Divya Choudhary, Aashika Sekar, Anupam Patra, Neel Sarovar Bhavesh, Perumal Vivekanandan   +6 more
doaj   +1 more source

Thermally Induced Transitions of d(G₄T₄G₃) Quadruplexes Can Be Described as Kinetically Driven Processes

Life, 2022
DNA sequences that are rich in guanines and can form four-stranded structures are called G-quadruplexes. Due to the growing evidence that they may play an important role in several key biological processes, the G-quadruplexes have captured the interest ...
Iztok Prislan, Tomaz Urbic, Natasa Poklar Ulrih   +2 more
doaj   +1 more source

Intramolecular telomeric G-quadruplexes dramatically inhibit DNA synthesis by replicative and translesion polymerases, revealing their potential to lead to genetic change. [PDF]

PLoS ONE, 2014
Recent research indicates that hundreds of thousands of G-rich sequences within the human genome have the potential to form secondary structures known as G-quadruplexes. Telomeric regions, consisting of long arrays of TTAGGG/AATCCC repeats, are among the
Deanna N Edwards, Amrita Machwe, Zhigang Wang, David K Orren   +3 more
doaj   +1 more source

A new cationic porphyrin derivative (TMPipEOPP) with large side arm substituents: a highly selective G-quadruplex optical probe. [PDF]

PLoS ONE, 2012
The discovery of uncommon DNA structures and speculation about their potential functions in genes has brought attention to specific DNA structure recognition.
Li-Na Zhu, Shu-Juan Zhao, Bin Wu, Xiao-Zeng Li, De-Ming Kong   +4 more
doaj   +1 more source