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G‐Quadruplex Nucleic Acids [PDF]
Journal of Nucleic Acids, 2010 Peer ...
ERITJA R. +4 more
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Polyelectrolyte effects in G-quadruplexes [PDF]
Biophysical Chemistry, 2013 The role of counterion condensation as a dominant force governing the stability of DNA duplexes and triplexes is well established. In contrast, the effect of counterion condensation on the stability of G-quadrupex conformations is poorly understood. Unlike other ordered nucleic acid structures, G-quadruplexes exhibit a specific binding of counterions ...
Kim, Byul +2 more
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Helquat dyes targeting G-quadruplexes as a new class of anti-HIV-1 inhibitors
Scientific Reports, 2023 The secondary structure of nucleic acids containing quartets of guanines, termed G-quadruplexes, is known to regulate the transcription of many genes.
Marcela Pávová +7 more
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Scientific Reports, 2022 Herpesviruses are known to acquire several genes from their hosts during evolution. We found that a significant proportion of virus homologues encoded by HSV-1, HSV-2, EBV and KSHV and their human counterparts contain G-quadruplex motifs in their ...
Shivani Kumar +6 more
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G-quadruplexes self-assembled from nucleotide monomers as stable prepolymer scaffolds in aqueous environments. [PDF]
Sci RepLife is composed of genetic and functional polymers, such as nucleic acids. For life to have emerged, a prebiotic mechanism for assembling these polymers is essential.
Eiby SHJ +4 more
europepmc +2 more sources
Life, 2022 DNA sequences that are rich in guanines and can form four-stranded structures are called G-quadruplexes. Due to the growing evidence that they may play an important role in several key biological processes, the G-quadruplexes have captured the interest ...
Iztok Prislan +2 more
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G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2011 G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. DNA G-quadruplexes have recently emerged as attractive cancer therapeutic targets. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures.
Raveendra I, Mathad, Danzhou, Yang
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Intramolecular telomeric G-quadruplexes dramatically inhibit DNA synthesis by replicative and translesion polymerases, revealing their potential to lead to genetic change. [PDF]
PLoS ONE, 2014 Recent research indicates that hundreds of thousands of G-rich sequences within the human genome have the potential to form secondary structures known as G-quadruplexes. Telomeric regions, consisting of long arrays of TTAGGG/AATCCC repeats, are among the
Deanna N Edwards +3 more
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A new cationic porphyrin derivative (TMPipEOPP) with large side arm substituents: a highly selective G-quadruplex optical probe. [PDF]
PLoS ONE, 2012 The discovery of uncommon DNA structures and speculation about their potential functions in genes has brought attention to specific DNA structure recognition.
Li-Na Zhu +4 more
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G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]
Nucleic Acids Research, 2018 G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in recent years the presence of G4s in viruses has attracted increasing interest.
Emanuela Ruggiero, Sara N Richter
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