Results 21 to 30 of about 9,085,971 (219)
RNA G-quadruplexes and their potential regulatory roles in translation
Translation, 2016 : DNA guanine (G)-rich 4-stranded helical nucleic acid structures called G-quadruplexes (G4), have been extensively studied during the last decades. However, emerging evidence reveals that 50- and 30-untranslated regions (50- and 30-UTRs) as well as ...
Perreault, Jean-Pierre
core +3 more sources
Biochemistry and Biophysics Reports, 2016 Environments surrounding G-rich sequences remarkably affect the conformations of these structures. A proper evaluation system mimicking the crowded environment in a cell with macromolecules should be developed to perform structural and functional studies
Shi-Ke Wang +6 more
doaj +2 more sources
G-Quadruplexes and Their Ligands: Biophysical Methods to Unravel G-Quadruplex/Ligand Interactions [PDF]
Pharmaceuticals, 2021 Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of approaches that assess the binding mode and nature of the interactions between G4 forming sequences and their putative ligands. The experimental approaches used to characterize G4/ligand interactions can be categorized into structure-based methods (circular ...
Tiago Santos +3 more
openaire +4 more sources
G-Quadruplexes in the Archaea Domain [PDF]
Biomolecules, 2020 The importance of unusual DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, G-quadruplexes (G4s) have gained in popularity during the last decade, and their presence and functional relevance at the DNA and RNA level has been demonstrated in a number of viral, bacterial ...
Václav Brázda +13 more
openaire +6 more sources
G-quadruplexes and helicases [PDF]
Nucleic Acids Research, 2016 Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as 'knots' within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures.
Mendoza, Oscar +4 more
openaire +3 more sources
G‐Quadruplex Nucleic Acids [PDF]
Journal of Nucleic Acids, 2010 Peer ...
ERITJA R. +4 more
openaire +5 more sources
Polyelectrolyte effects in G-quadruplexes [PDF]
Biophysical Chemistry, 2013 The role of counterion condensation as a dominant force governing the stability of DNA duplexes and triplexes is well established. In contrast, the effect of counterion condensation on the stability of G-quadrupex conformations is poorly understood. Unlike other ordered nucleic acid structures, G-quadruplexes exhibit a specific binding of counterions ...
Kim, Byul +2 more
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G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2011 G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. DNA G-quadruplexes have recently emerged as attractive cancer therapeutic targets. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures.
Raveendra I, Mathad, Danzhou, Yang
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eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes [PDF]
, 2018 Increased activity of the mRNA helicase eIF4A drives cellular malignancy by reprogramming cellular translation, and eIF4A activity is the direct or indirect target of many emerging cancer therapeutics.
Raza, Farheen +8 more
core +2 more sources