Results 31 to 40 of about 9,012 (187)
G-quadruplexes in helminth parasites
Nucleic Acids Research, 2022 Abstract Parasitic helminths infecting humans are highly prevalent infecting ∼2 billion people worldwide, causing inflammatory responses, malnutrition and anemia that are the primary cause of morbidity. In addition, helminth infections of cattle have a significant economic impact on livestock production, milk yield and fertility.
Cantara, Alessio +13 more
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Biophysical Characterization of G-Quadruplex Recognition in the PITX1 mRNA by the Specificity Domain of the Helicase RHAU. [PDF]
PLoS ONE, 2015 Nucleic acids rich in guanine are able to fold into unique structures known as G-quadruplexes. G-quadruplexes consist of four tracts of guanylates arranged in parallel or antiparallel strands that are aligned in stacked G-quartet planes. The structure is
Emmanuel O Ariyo +8 more
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Molecules, 2021 G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in recent years as novel targets, with untapped potential for anticancer research. Their potential stems from the fact that G-quadruplexes occur in functionally-important
Loukiani Savva, Savvas N. Georgiades
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Molecular Recognition of the Hybrid-Type G-Quadruplexes in Human Telomeres
Molecules, 2019 G-quadruplex (G4) DNA secondary structures formed in human telomeres have been shown to inhibit cancer-specific telomerase and alternative lengthening of telomere (ALT) pathways.
Guanhui Wu +3 more
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Integrative characterization of G-Quadruplexes in the three-dimensional chromatin structure
Epigenetics, 2019 DNA molecules are highly compacted in the eukaryotic nucleus where distal regulatory elements reach their targets through three-dimensional chromosomal interactions.
Yue Hou +6 more
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Why are G-quadruplexes good at preventing protein aggregation?
RNA Biology, 2023 Maintaining a healthy protein folding environment is essential for cellular function. Recently, we found that nucleic acids, G-quadruplexes in particular, are potent chaperones for preventing protein aggregation.
Theodore J. Litberg +5 more
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Replication of G Quadruplex DNA [PDF]
Genes, 2019 A cursory look at any textbook image of DNA replication might suggest that the complex machine that is the replisome runs smoothly along the chromosomal DNA. However, many DNA sequences can adopt non-B form secondary structures and these have the potential to impede progression of the replisome.
Leticia Koch Lerner, Julian E. Sale
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Structure and Function of Multimeric G-Quadruplexes
Molecules, 2019 G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine tetrads. They are frequently used as building blocks and functional elements in fields such as synthetic biology and also thought to play widespread biological roles.
Sofia Kolesnikova, Edward A. Curtis
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Multimerization rules for G-quadruplexes [PDF]
Nucleic Acids Research, 2017 G-quadruplexes can multimerize under certain conditions, but the sequence requirements of such structures are not well understood. In this study, we investigated the ability of all possible variants of the central tetrad in a monomeric, parallel-strand G-quadruplex to form higher-order structures.
Kolesnikova, S. (Sofia) +4 more
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Frontiers in Genetics, 2020 The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has become a global public health emergency.
Rongxin Zhang +4 more
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