An in silico study of the differential effect of oxidation on two biologically relevant G-quadruplexes: Possible implications in oncogene expression [PDF]
, 2012 G-quadruplex structures, formed from guanine rich sequences, have previously been shown to be involved in various physiological processes including cancer-related gene expression.
William J D Stebbeds +14 more
core +1 more source
Stable-bulged-G-quadruplexes-in-the-human-genome_2022-2023
, 2023 Project data for "Stable bulged G-quadruplexes in the human genome: Identification, experimental validation and functionalization" (2022 ...
Piroon Jenjaroenpun (5212082) +6 more
core +1 more source
G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]
Nucleic Acids Research, 2018 G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in recent years the presence of G4s in viruses has attracted increasing interest.
Emanuela Ruggiero, Sara N Richter
openaire +2 more sources
G-quadruplexes in helminth parasites
Nucleic Acids Research, 2022 Abstract Parasitic helminths infecting humans are highly prevalent infecting ∼2 billion people worldwide, causing inflammatory responses, malnutrition and anemia that are the primary cause of morbidity. In addition, helminth infections of cattle have a significant economic impact on livestock production, milk yield and fertility.
Cantara, Alessio +13 more
openaire +3 more sources
Biophysical Characterization of G-Quadruplex Recognition in the PITX1 mRNA by the Specificity Domain of the Helicase RHAU. [PDF]
PLoS ONE, 2015 Nucleic acids rich in guanine are able to fold into unique structures known as G-quadruplexes. G-quadruplexes consist of four tracts of guanylates arranged in parallel or antiparallel strands that are aligned in stacked G-quartet planes. The structure is
Emmanuel O Ariyo +8 more
doaj +1 more source
Molecules, 2021 G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in recent years as novel targets, with untapped potential for anticancer research. Their potential stems from the fact that G-quadruplexes occur in functionally-important
Loukiani Savva, Savvas N. Georgiades
doaj +1 more source
Molecular Recognition of the Hybrid-Type G-Quadruplexes in Human Telomeres
Molecules, 2019 G-quadruplex (G4) DNA secondary structures formed in human telomeres have been shown to inhibit cancer-specific telomerase and alternative lengthening of telomere (ALT) pathways.
Guanhui Wu +3 more
doaj +1 more source
Role of the central cations in the mechanical unfolding of DNA and RNA G-quadruplexes. [PDF]
, 2015 Cations are known to mediate diverse interactions in nucleic acids duplexes but they are critical in the arrangement of four-stranded structures. Here, we use all-atom molecular dynamics simulations with explicit solvent to analyse the mechanical ...
Bergues-Pupo, AE +25 more
core +1 more source
Why are G-quadruplexes good at preventing protein aggregation?
RNA Biology, 2023 Maintaining a healthy protein folding environment is essential for cellular function. Recently, we found that nucleic acids, G-quadruplexes in particular, are potent chaperones for preventing protein aggregation.
Theodore J. Litberg +5 more
doaj +1 more source
Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity [PDF]
, 2013 G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome.
NADAI, MATTEO +36 more
core +1 more source