Results 51 to 60 of about 9,012 (187)
G-Quadruplexes at Telomeres: Friend or Foe?
Molecules, 2020 Telomeres are DNA-protein complexes that cap and protect the ends of linear chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short tandem repeats of the G-rich strand have the capacity to form into secondary structures in ...
Tracy M. Bryan
doaj +1 more source
Kinetics and thermodynamics of G-quadruplexes [PDF]
Nucleic Acids Symposium Series, 2005 The melting of tetramolecular DNA or RNA quadruplexes is kinetically irreversible. However, rather than being a hindrance, this kinetic inertia allows us to study association and dissociation processes independently. General rules have been extended to longer DNA motifs or sequences containing modified bases such as 8-oxo or 7-deaza guanine.
Julien, Gros +9 more
openaire +2 more sources
PlantsG-quadruplexes play a crucial role in transcription, translation, and DNA replication in plant genomes. Here, we comprehensively examined the prevalence and functions of G-quadruplexes in Vitis vinifera.
Jun Xie +8 more
doaj +1 more source
Molecules, 2019 G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome. G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or ...
Zhi-Yin Sun +4 more
doaj +1 more source
Journal of Chemical Research, 2023 A label- and enzyme-free fluorescence assay based on thioflavin T–induced G-quadruplexes is developed to sensitively and specifically detect telomerase activity.
Zhe Chen, Yunxia Wang
doaj +1 more source
Antioxidants, 2021 G-quadruplexes (G4) are stacked nucleic acid structures that are stabilized by heme. In cells, they affect DNA replication and gene transcription. They are unwound by several helicases but the composition of the repair complex and its heme sensitivity ...
Wojciech Krzeptowski +17 more
doaj +1 more source
Isothermal folding of G-quadruplexes [PDF]
Methods, 2012 Thermodynamic studies of G-quadruplex stability are an essential complement to structures obtained by NMR or X-ray crystallography. An understanding of the energetics of quadruplex folding provides a necessary foundation for the physical interpretation of quadruplex formation and reactivity.
Gray, Robert D, Chaires, Jonathan B
openaire +2 more sources
New Modified Deoxythymine with Dibranched Tetraethylene Glycol Stabilizes G-Quadruplex Structures
Molecules, 2020 Methods for stabilizing G-quadruplex formation is a promising therapeutic approach for cancer treatment and other biomedical applications because stable G-quadruplexes efficiently inhibit biological reactions. Oligo and polyethylene glycols are promising
Hisae Tateishi-Karimata +5 more
doaj +1 more source
A Photoresponsive Supramolecular G-Quadruplex [PDF]
Organic Letters, 2013 Photoirradiation of a hexadecameric supramolecular G-quadruplex leads to a diastereoselective [2 + 2] cyclodimerization of half of its constituent subunits, which in turn shifts the equilibrium toward the formation of a precise heteromeric octamer.
José M, Rivera, Diana, Silva-Brenes
openaire +2 more sources
G-Quadruplexes Are Present in Human Coronaviruses Including SARS-CoV-2
Frontiers in Microbiology, 2020 The global coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is one of seven human coronaviruses. G-quadruplexes are intrinsic obstacles to genome replication.
Haoran Cui +3 more
doaj +1 more source