Results 61 to 70 of about 9,012 (187)

G-quadruplex organic frameworks [PDF]

Nature Chemistry, 2016
Two-dimensional covalent organic frameworks often π stack into crystalline solids that allow precise spatial positioning of molecular building blocks. Inspired by the hydrogen-bonded G-quadruplexes found frequently in guanine-rich DNA, here we show that this structural motif can be exploited to guide the self-assembly of naphthalene diimide and ...
Yi-Lin Wu, Noah E. Horwitz, Kan-Sheng Chen, Diego A. Gomez-Gualdron, Norman S. Luu, Lin Ma, Timothy C. Wang, Mark C. Hersam, Joseph T. Hupp, Omar K. Farha, Randall Q. Snurr, Michael R. Wasielewski   +11 more
openaire   +3 more sources

Interaction between non-coding RNAs, mRNAs and G-quadruplexes

Cancer Cell International, 2022
G-quadruplexes are secondary helical configurations established between guanine-rich nucleic acids. The structure is seen in the promoter regions of numerous genes under certain situations.
Soudeh Ghafouri-Fard, Atefe Abak, Aria Baniahmad, Bashdar Mahmud Hussen, Mohammad Taheri, Elena Jamali, Marcel E. Dinger   +6 more
doaj   +1 more source

The potential interplay between G-quadruplex and p53: their roles in regulation of ferroptosis in cancer

Frontiers in Molecular Biosciences, 2022
Ferroptosis is a novel form of regulated cell death trigged by various biological processes, and p53 is involved in different ferroptosis regulations and functions as a crucial regulator. Both DNA and RNA can fold into G-quadruplex in GC-rich regions and
Lulu Zhang, Lulu Zhang, Yi Lu, Xiaoli Ma, Xiaoli Ma, Yuanxin Xing, Yuanxin Xing, Jinbo Sun, Yanfei Jia, Yanfei Jia   +9 more
doaj   +1 more source

Control of the polyamine biosynthesis pathway by G2-quadruplexes

eLife, 2018
G-quadruplexes are naturally-occurring structures found in RNAs and DNAs. Regular RNA G-quadruplexes are highly stable due to stacked planar arrangements connected by short loops.
Helen Louise Lightfoot, Timo Hagen, Antoine Cléry, Frédéric Hai-Trieu Allain, Jonathan Hall   +4 more
doaj   +1 more source

G-quadruplexes in Prague: A Bohemian Rhapsody [PDF]

Biochimie, 2018
The Sixth International Meeting on Quadruplex Nucleic Acids was held at the Hotel Internationale in Prague, Czech Republic from 31 May - 3 June 2017. A vibrant interdisciplinary community of over 300 scientists gathered to share their newest results in this exciting field and exchange ideas for further investigations.
Michael Paul O'Hagan, Jean-Louis Mergny, Zoë Ann Ella Waller   +2 more
openaire   +4 more sources

Analysis of G-quadruplexes upstream of herpesvirus miRNAs: evidence of G-quadruplex mediated regulation of KSHV miR-K12–1-9,11 cluster and HCMV miR-US33

BMC Molecular and Cell Biology, 2020
Background G-quadruplexes regulate gene expression, recombination, packaging and latency in herpesviruses. Herpesvirus-encoded miRNAs have been linked to important biological functions. The presence and the biological role of G-quadruplexes have not been
Shivani Kumar, Divya Choudhary, Anupam Patra, Neel Sarovar Bhavesh, Perumal Vivekanandan   +4 more
doaj   +1 more source

Simultaneous G‐Quadruplex DNA Logic [PDF]

Chemistry – A European Journal, 2018
AbstractA fundamental principle of digital computer operation is Boolean logic, where inputs and outputs are described by binary integer voltages. Similarly, inputs and outputs may be processed on the molecular level as exemplified by synthetic circuits that exploit the programmability of DNA base‐pairing.
Antoine Bader, Scott L. Cockroft
openaire   +3 more sources

Dynamic Control of Nucleic Acids Self‐Assembly and Expression Using Photoswitches

Chemistry – A European Journal, Volume 32, Issue 31, 18 August 2026.
We review here the recent progress made in the design of molecular photoswitches, and highlight their implementation for the dynamic control over nucleic acids self‐assembly and expression. ABSTRACT Synthetic nucleic acids have become readily available and now constitute versatile building blocks in materials science—where they can be used to engineer ...
Noemí Nogal, Hugo Laigle, Maxime Mansy, Sébastien Ulrich, Mathieu Surin   +4 more
wiley   +1 more source

High-resolution AFM structure of DNA G-wires in aqueous solution

Nature Communications, 2018
DNA and RNA G-quadruplexes can stack to form higher-order structures called G-wires. Here the authors report high-resolution AFM images of higher-order DNA G-quadruplexes in aqueous solution that could impact the design of G-wire based nanodevices and ...
Krishnashish Bose, Christopher J. Lech, Brahim Heddi, Anh Tuân Phan   +3 more
doaj   +1 more source

Unraveling G‐Quadruplex and i‐Motif Coexistence Within a Double‐Stranded DNA

Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.
The relative thermodynamic profiles of G‐quadruplex (G4), i‐Motif (iM), and the duplex counterpart tune the simultaneous G4 and iM formation within a double‐stranded (ds) DNA. ABSTRACT DNA can transiently fold into variable arrangements, which are expected to exploit regulatory functions. Guanine‐rich sequences can fold into G‐quadruplexes (G4s), while
Davide Auricchio, Michele Ghezzo, Uroš Zavrtanik, Luca Bertini, Valeria Libera, Riccardo Rigo, Jurij Lah, Claudia Sissi   +7 more
wiley   +2 more sources