Results 71 to 80 of about 9,085,971 (219)

Characterization and targeting of G-quadruplexes in the genome of Kaposi's sarcoma-associated herpesvirus

open access: yes, 2023
reservedKaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus capable of establishing life-long latent infections in host cells, ultimately resulting in Kaposi’s sarcoma, an incurable cancer affecting immunocompromised patients ...
MARCHIORI, ILARIA
core  

The potential interplay between G-quadruplex and p53: their roles in regulation of ferroptosis in cancer

open access: yesFrontiers in Molecular Biosciences, 2022
Ferroptosis is a novel form of regulated cell death trigged by various biological processes, and p53 is involved in different ferroptosis regulations and functions as a crucial regulator. Both DNA and RNA can fold into G-quadruplex in GC-rich regions and
Lulu Zhang   +9 more
doaj   +1 more source

G-quadruplexes in Prague: A Bohemian Rhapsody [PDF]

open access: yesBiochimie, 2018
The Sixth International Meeting on Quadruplex Nucleic Acids was held at the Hotel Internationale in Prague, Czech Republic from 31 May - 3 June 2017. A vibrant interdisciplinary community of over 300 scientists gathered to share their newest results in this exciting field and exchange ideas for further investigations.
Michael Paul O'Hagan   +2 more
openaire   +4 more sources

Control of the polyamine biosynthesis pathway by G2-quadruplexes

open access: yeseLife, 2018
G-quadruplexes are naturally-occurring structures found in RNAs and DNAs. Regular RNA G-quadruplexes are highly stable due to stacked planar arrangements connected by short loops.
Helen Louise Lightfoot   +4 more
doaj   +1 more source

Simultaneous G‐Quadruplex DNA Logic [PDF]

open access: yesChemistry – A European Journal, 2018
AbstractA fundamental principle of digital computer operation is Boolean logic, where inputs and outputs are described by binary integer voltages. Similarly, inputs and outputs may be processed on the molecular level as exemplified by synthetic circuits that exploit the programmability of DNA base‐pairing.
Antoine Bader, Scott L. Cockroft
openaire   +3 more sources

G-quadruplexes in pathogens.

open access: yes, 2015
Pathogens known or hypothesised to contain G-quadruplexes involved in virulence phenotypes. Brackets indicate hypothesised G4 functions which could influence the virulence phenotypes indicated.
Catherine J. Merrick (689450)   +1 more
core   +1 more source

Analysis of G-quadruplexes upstream of herpesvirus miRNAs: evidence of G-quadruplex mediated regulation of KSHV miR-K12–1-9,11 cluster and HCMV miR-US33

open access: yesBMC Molecular and Cell Biology, 2020
Background G-quadruplexes regulate gene expression, recombination, packaging and latency in herpesviruses. Herpesvirus-encoded miRNAs have been linked to important biological functions. The presence and the biological role of G-quadruplexes have not been
Shivani Kumar   +4 more
doaj   +1 more source

Interaction between non-coding RNAs, mRNAs and G-quadruplexes

open access: yesCancer Cell International, 2022
G-quadruplexes are secondary helical configurations established between guanine-rich nucleic acids. The structure is seen in the promoter regions of numerous genes under certain situations.
Soudeh Ghafouri-Fard   +6 more
doaj   +1 more source

High-resolution AFM structure of DNA G-wires in aqueous solution

open access: yesNature Communications, 2018
DNA and RNA G-quadruplexes can stack to form higher-order structures called G-wires. Here the authors report high-resolution AFM images of higher-order DNA G-quadruplexes in aqueous solution that could impact the design of G-wire based nanodevices and ...
Krishnashish Bose   +3 more
doaj   +1 more source

Highly Potent Fluorogenic Ligands for Triplex DNA: 5‐Substituted 2‐(Naphthalen‐2‐yl)‐4H‐Chromen‐4‐Ones

open access: yesChemistry – A European Journal, EarlyView.
5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran   +4 more
wiley   +1 more source

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