Results 91 to 100 of about 9,085,971 (219)
The FEBS Journal, EarlyView.Base‐pair opening and closing regulate nucleic‐acid structure, stability, and function, but how these motions behave under intracellular molecular crowding remains unclear. Using NMR, we quantified these dynamics in a DNA triplex under two crowder‐reconstituted environments that mimic cellular crowding.
Tomoki Sakamoto +3 more
wiley +1 more source
G-Quadruplex DNA and RNA [PDF]
, 2019 G-quadruplexes (G4s) have become one of the most exciting nucleic acid secondary structures. A noncanonical, four-stranded structure formed in guanine-rich DNA and RNA sequences, G-quadruplexes can readily form under physiologically relevant conditions and are globularly folded structures.
openaire +2 more sources
Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications
WIREs RNA, Volume 17, Issue 4, July/August 2026.Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus +5 more
wiley +1 more source
Effects of cation charges on the binding of stabilizers with human telomere and TERRA G-quadruplexes
, 2019 Both telomere and telomeric repeat-containing RNAs (TERRA) can fold into G-quadruplexes (G4) in eukaryotic cells. Given their key roles in the regulation of telomere length and translation, telomere and TERRA G4 are interesting targets of novel drug ...
Zhiguo Wang (219272) +2 more
core +1 more source
Journal of Pineal Research, Volume 78, Issue 4, July 2026.ABSTRACT Oncogenic condensates act as biophysical sanctuaries that stabilize malignant survival programs. However, a universal regulator capable of orchestrating the integrated biophysical axes governing cellular phase behavior has remained elusive.
Doris Loh +3 more
wiley +1 more source
G-quadruplexes: Kinetic stability and effects on the c-KIT promoter
, 2013 In addition to the famous Watson & Crick model for B-form duplex DNA, guanine-rich DNA sequences can self-assemble under certain conditions to form a four-stranded structure known as a G-quadruplex. G-quadruplexes are composed of stacks of Gquartets,
Raouf, Tara
core
Supramolecular DNA-based catalysis in organic solvents
iScienceSummary: The distinct folding accompanied by its polymorphic character renders DNA G-quadruplexes promising biomolecular building blocks to construct novel DNA-based and supramolecular assemblies. However, the highly polar nature of DNA limits the use of
Gurudas Chakraborty +10 more
doaj +1 more source
Simple Guanosine—Amino Acid Hybrids as Low Molecular Weight Hydrogelators
Chemistry – A European Journal, Volume 32, Issue 23, 16 June 2026.Unexplored guanosine‐amino acid derivatives act as low molecular weight hydrogelators. Gelation is triggered by K+ ions and pH changes and relies on G‐quadruplex formation. Small changes in the amino acid structure have a strong impact on the mechanical properties of the gels.
Silvia Pieraccini +6 more
wiley +1 more source
Sequence Requirements of Intrinsically Fluorescent G‑Quadruplexes
, 2018 G-Quadruplexes are four-stranded nucleic acid structures typically stabilized by GGGG tetrads. These structures are intrinsically fluorescent, which expands the known scope of nucleic acid function and raises the possibility that they could eventually be
Tereza Streckerová (5463584) +3 more
core +1 more source
Targeting telomeric DNA/RNA G-quadruplexes in human tumor cells
, 2014 Among the known nucleic acids structures, G-quadruplexes display an unprecedented structural variability never observed so far in nucleic acids. Thus, one of the main aims of this research project is the identification of drug-like molecules capable to ...
RANDAZZO, ANTONIO
core