Results 111 to 120 of about 9,085,971 (219)
Human Papillomavirus G‑Quadruplexes
, 2016 Infection with human papillomaviruses (HPVs) is one of the most common sexually transmitted infections and can lead to development of head and neck, skin, and anogenital cancer, including cervical cancer, which represents one of the world’s most ...
Primož Šket (1651762) +6 more
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Targeting RNA G-Quadruplexes for Potential Therapeutic Applications [PDF]
, 2017 RNA G-quadruplexes are non-canonical structures formed in G-rich regions of transcriptome. Considerable research points towards the potential role for these dynamic structures in various genes involved in multiple pathways.
Souvik Maiti +5 more
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G-Quadruplexes as An Alternative Recognition Element in Disease-Related Target Sensing
Molecules, 2019 G-quadruplexes are made up of guanine-rich RNA and DNA sequences capable of forming noncanonical nucleic acid secondary structures. The base-specific sterical configuration of G-quadruplexes allows the stacked G-tetrads to bind certain planar molecules ...
Jeunice Ida +5 more
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Tetrahelical structural family adopted by AGCGA-rich regulatory DNA regions
Nature Communications, 2017 DNA tetrahelical structures such as G-quadruplexes are known to play important roles in DNA replication and repair. Here the authors present the structure of 5′-AGCGA-3′-quadruplexes enriched in genetic regulatory regions.
Vojč Kocman, Janez Plavec
doaj +1 more source
Transcription Driven by Reversible Photocontrol of Hyperstable G‑Quadruplexes
, 2018 G-quadruplexes occur in promoter regions, 5′-untranslated regions of mRNA and telomeric regions, and they function as regulatory elements for various key biological events, such as transcription, translation, and telomere elongation.
Shinzi Ogasawara (2426575)
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Hindered intermolecular stacking of anti-parallel telomeric G-quadruplexes
Telomeric G-quadruplexes (G4s) are non-canonical DNA structures composed of TTAGGG repeats. They are extensively studied both as biomolecules key for genome stability and as promising building blocks and functional elements in synthetic biology and ...
Bertini L. +11 more
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Fundamentals of G-quadruplex biology
, 2020 Several decades elapsed between the first descriptions of G-quadruplex nucleic acid structures (G4s) assembled in vitro and the emergence of experimental findings indicating that such structures can form and function in living systems. A large body of evidence now supports roles for G4s in many aspects of nucleic acid biology, spanning processes from ...
openaire +2 more sources
Targeting G-quadruplex DNA as Potential Anti-cancer Therapy
, 2017 This chapter provides an introduction and also a review on non-canonical DNA structures such as guanine-quadruplexes (G-quadruplexes) and their targeting by small molecules for applications in Pharmacology.
Trippodo E., Barone G., Bonsignore R.
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Fluorescence Turn-Off Ligand for Parallel G-Quadruplexes
MoleculesParallel-stranded G-quadruplex structures are found to be common in the human promoter sequences. We tested highly fluorescent 9-methoxyluminarine ligand (9-MeLM) binding interactions with different parallel G-quadruplexes DNA by spectroscopic methods ...
Joanna Nowak-Karnowska +3 more
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Engineering of interlocked DNA G-quadruplexes as a robust scaffold
, 2012 Interlock is a structural element in DNA G-quadruplexes that can be compared with the commonly used complementary binding of ‘sticky ends’ in DNA duplexes. G-quadruplex interlocking can be a basis for the assembly of higher-order structures. In this
Do, Ngoc Quang, Phan, Anh Tuân
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