Results 101 to 110 of about 9,085,971 (219)
, 2014 International audienceIn this review, we introduce the biophysical and biochemical methods currently used to investigate the structures and stabilities of tetramolecular DNA G-quadruplexes containing chemical modifications.
Mergny, Jean-Louis +5 more
core +1 more source
Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development
Cell Reports, 2015 RNA G-quadruplexes (G4s) play important roles in RNA biology. However, the function and regulation of mRNA G-quadruplexes in embryonic development remain elusive.
Junwei Nie +12 more
doaj +1 more source
Hairpin oligonucleotides forming G-quadruplexes: New aptamers with anti-HIV activity
, 2015 We describe the facile syntheses of new modified oligonucleotides based on d(TG3AG) that form bimolecular G-quadruplexes and possess a HEG loop as an inversion of polarity site 3′-3′ or 5′-5′ and aromatic residues conjugated to the 5′-end through ...
Liekens S +8 more
core +1 more source
Hidden Fungal DNA Structures May Shape Sequencing Outcomes
BioEssays, Volume 48, Issue 6, June 2026.Sequencing fungal DNA presents numerous challenges, and unexplored structural anomalies may be a contributor. Native ONT sequencing allows artefacts of disrupted pore translocation to be interrogated, facilitating mapping to genomic loci using raw signal analyses. Subsequent visualization tools could reveal novel genome architectures and drive advances
Paul W. Thomas
wiley +1 more source
Scalable Flow Reactors for Stable Biofilm Formation and Continuous Whole‐Cell Catalysis
Small, Volume 22, Issue 31, 2 June 2026.Flow‐induced deposition enables the controlled formation of stable and long‐lived E. coli biofilms in modular, scalable microfluidic reactors. Hydrodynamic design principles, mechanistic insight into biofilm architecture and long‐term whole‐cell biocatalysis together establish a versatile platform for continuous microbial processing and the engineering
Sarah Gliemann +5 more
wiley +1 more source
Small, Volume 22, Issue 31, 2 June 2026.Switchable or transient formation and dissociation of the phase‐separated DNA microdroplets generated by metal ions or aptamer‐ligand complexes crosslinking Y‐shaped DNA frameworks and dynamically separated by counter ligands eliminating the bridging metal ions or biocatalysts degrading the aptamer‐ligand complexes, are introduced.
Yichen Han +6 more
wiley +1 more source
Potential G-quadruplexes in the human long non-coding transcriptome
, 2012 DNA G-quadruplexes are known as modulators of transcription. More recently G-quadruplexes, located in the untranslated regions of the mRNA of protein coding genes, have been described to negatively regulate gene expression at the post transcriptional ...
Pandey, Satyaprakash +3 more
core +1 more source
, 2023 reservedThe Herpes Simplex Virus-1 (HSV-1) is a double-stranded DNA virus that causes life-long infections in humans and establishes latency in the neuronal cells of the host.
MATTELLONE, FILIPPO
core
G-Quadruplex Structures in the Human Genome as Novel Therapeutic Targets
Molecules, 2013 G-quadruplexes are secondary structures that may form within guanine-rich nucleic acid sequences. Telomeres have received much attention in this regard since they can fold into several distinct intramolecular G-quadruplexes, leading to the rational ...
Joanna Bidzinska +3 more
doaj +1 more source
Epigenetics, 2018 Horvath’s epigenetic clock consists of 353 CpGs whose methylation levels can accurately predict the age of individuals. Using bioinformatics analysis, we investigated the conformation, energy characteristics and presence of tentative splice sites of the ...
Andigoni Malousi +5 more
doaj +1 more source