Results 81 to 90 of about 9,012 (187)
The FEBS Journal, Volume 293, Issue 16, Page 5067-5083, August 2026.Base‐pair opening and closing regulate nucleic‐acid structure, stability, and function, but how these motions behave under intracellular molecular crowding remains unclear. Using NMR, we quantified these dynamics in a DNA triplex under two crowder‐reconstituted environments that mimic cellular crowding.
Tomoki Sakamoto +3 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.Die Kontrolle biologischer Systeme mit organischen Chromophoren hat sich zu einer vielversprechenden Strategie entwickelt und findet Anwendung von der chemischen Biologie bis hin zur Medizin. Die Komplexität von In‐vivo‐Systemen lässt sich jedoch nicht mit nur einer einzigen Lichtwellenlänge adäquat abbilden.
Nadja A. Simeth
wiley +1 more source
Supramolecular DNA-based catalysis in organic solvents
iScienceSummary: The distinct folding accompanied by its polymorphic character renders DNA G-quadruplexes promising biomolecular building blocks to construct novel DNA-based and supramolecular assemblies. However, the highly polar nature of DNA limits the use of
Gurudas Chakraborty +10 more
doaj +1 more source
G-Quadruplex DNA and RNA [PDF]
, 2019 G-quadruplexes (G4s) have become one of the most exciting nucleic acid secondary structures. A noncanonical, four-stranded structure formed in guanine-rich DNA and RNA sequences, G-quadruplexes can readily form under physiologically relevant conditions and are globularly folded structures.
openaire +2 more sources
Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development
Cell Reports, 2015 RNA G-quadruplexes (G4s) play important roles in RNA biology. However, the function and regulation of mRNA G-quadruplexes in embryonic development remain elusive.
Junwei Nie +12 more
doaj +1 more source
G-Quadruplexes as An Alternative Recognition Element in Disease-Related Target Sensing
Molecules, 2019 G-quadruplexes are made up of guanine-rich RNA and DNA sequences capable of forming noncanonical nucleic acid secondary structures. The base-specific sterical configuration of G-quadruplexes allows the stacked G-tetrads to bind certain planar molecules ...
Jeunice Ida +5 more
doaj +1 more source
G-Quadruplex Structures in the Human Genome as Novel Therapeutic Targets
Molecules, 2013 G-quadruplexes are secondary structures that may form within guanine-rich nucleic acid sequences. Telomeres have received much attention in this regard since they can fold into several distinct intramolecular G-quadruplexes, leading to the rational ...
Joanna Bidzinska +3 more
doaj +1 more source
Epigenetics, 2018 Horvath’s epigenetic clock consists of 353 CpGs whose methylation levels can accurately predict the age of individuals. Using bioinformatics analysis, we investigated the conformation, energy characteristics and presence of tentative splice sites of the ...
Andigoni Malousi +5 more
doaj +1 more source
Biochemistry and Biophysics Reports, 2016 Environments surrounding G-rich sequences remarkably affect the conformations of these structures. A proper evaluation system mimicking the crowded environment in a cell with macromolecules should be developed to perform structural and functional studies
Shi-Ke Wang +6 more
doaj +1 more source
Tetrahelical structural family adopted by AGCGA-rich regulatory DNA regions
Nature Communications, 2017 DNA tetrahelical structures such as G-quadruplexes are known to play important roles in DNA replication and repair. Here the authors present the structure of 5′-AGCGA-3′-quadruplexes enriched in genetic regulatory regions.
Vojč Kocman, Janez Plavec
doaj +1 more source