Results 41 to 50 of about 9,012 (187)
A label-free thrombin photoelectrochemical aptasensor based on structure-switching in G-quadruplexes
Biosensors and Bioelectronics: X, 2022 In this work, an Au/GaN photoelectrode was prepared by sputtering a 30.0-nm–thick gold film on an n-type gallium nitride (GaN) surface. Guanine (G) was used as a hole trap in photoinduced charge separation due to its lowest oxidation potential and ...
Xiujun Rong +9 more
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G-Quadruplexes in Human Telomere: Structures, Properties, and Applications
Molecules, 2023 G-quadruplexes, intricate four-stranded structures composed of G-tetrads formed by four guanine bases, are prevalent in both DNA and RNA. Notably, these structures play pivotal roles in human telomeres, contributing to essential cellular functions ...
Yan Xu, Makoto Komiyama
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Human Telomeric G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2017 G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures, and the human telomeric DNA G-quadruplexes are considered attractive targets for anticancer drugs.
Clement, Lin, Danzhou, Yang
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Profusion of G-quadruplexes on both subunits of metazoan ribosomes.
PLoS ONE, 2019 Mammalian and bird ribosomes are nearly twice the mass of prokaryotic ribosomes in part because of their extraordinarily long rRNA tentacles. Human rRNA tentacles are not fully observable in current three-dimensional structures and their conformations ...
Santi Mestre-Fos +6 more
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Epigenetics, 2021 The presence of 5-hydroxymethyl cytosine in DNA has been previously associated with ageing. Using in silico analysis of normal liver samples we presently observed that in 5-hydroxymethyl cytosine sequences, DNA methylation is dependent on the co-presence
Andigoni Malousi +2 more
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NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2019 G-quadruplexes are noncanonical, four-stranded nucleic acid secondary structures formed in sequences containing consecutive runs of guanines. These G-quadruplex structures have been found to form in nucleic acid regions of biological significance, including human telomeres, gene promoters, and untranslated regions of mRNA.
Clement, Lin +2 more
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Naphthalene Diimides as Multimodal G-Quadruplex-Selective Ligands
Molecules, 2019 G-quadruplexes are four-stranded nucleic acids structures that can form in guanine-rich sequences. Following the observation that G-quadruplexes are particularly abundant in genomic regions related to cancer, such as telomeres and oncogenes promoters ...
Valentina Pirota +3 more
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G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders [PDF]
Nucleic Acids Research, 2020 AbstractGenomic DNA and cellular RNAs can form a variety of non-B secondary structures, including G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held together by Hoogsteen hydrogen bonds and can form at key regulatory sites of eukaryote genomes and transcripts, including gene promoters, untranslated exon regions and ...
Giulia Miglietta +2 more
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PLoS ONE, 2022 We systematically investigated the influence of locked nucleic acid (LNA), unlock nucleic acid (UNA), and 2'-O-methyl-RNA (2'-O-Me-RNA) residues on the thermal stability, structure folding topology, biological activity and enzymatic resistance of three ...
Carolina Roxo, Anna Pasternak
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Stability of telomeric G-quadruplexes [PDF]
Nucleic Acids Research, 2010 In most eukaryotes, telomeric DNA consists of repeats of a short motif that includes consecutive guanines and may hence fold into G-quadruplexes. Budding yeasts have telomeres composed of longer repeats and show variation in the degree of repeat homogeneity. Although telomeric sequences from several organisms have been shown to fold into G-quadruplexes
Tran, Phong Lan Thao +2 more
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