Results 41 to 50 of about 9,085,971 (219)
Replication of G Quadruplex DNA [PDF]
Genes, 2019 A cursory look at any textbook image of DNA replication might suggest that the complex machine that is the replisome runs smoothly along the chromosomal DNA. However, many DNA sequences can adopt non-B form secondary structures and these have the potential to impede progression of the replisome.
Leticia Koch Lerner, Julian E. Sale
openaire +2 more sources
Multimerization rules for G-quadruplexes [PDF]
Nucleic Acids Research, 2017 G-quadruplexes can multimerize under certain conditions, but the sequence requirements of such structures are not well understood. In this study, we investigated the ability of all possible variants of the central tetrad in a monomeric, parallel-strand G-quadruplex to form higher-order structures.
Kolesnikova, S. (Sofia) +4 more
openaire +3 more sources
G-quadruplexes: prediction, characterization, and biological application [PDF]
, 2017 Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention for decades.
Chun Kit Kwok, Catherine J. Merrick
core +2 more sources
Frontiers in Genetics, 2020 The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has become a global public health emergency.
Rongxin Zhang +4 more
doaj +1 more source
A label-free thrombin photoelectrochemical aptasensor based on structure-switching in G-quadruplexes
Biosensors and Bioelectronics: X, 2022 In this work, an Au/GaN photoelectrode was prepared by sputtering a 30.0-nm–thick gold film on an n-type gallium nitride (GaN) surface. Guanine (G) was used as a hole trap in photoinduced charge separation due to its lowest oxidation potential and ...
Xiujun Rong +9 more
doaj +1 more source
GTP-Dependent Formation of Multimeric G‑Quadruplexes
, 2019 G-Quadruplexes are noncanonical nucleic acid structures made up of stacked guanosine tetrads connected by short loops. They are frequently used building blocks in synthetic biology and thought to play widespread biological roles.
Václav Veverka (1321008) +5 more
core +3 more sources
Human Telomeric G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2017 G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures, and the human telomeric DNA G-quadruplexes are considered attractive targets for anticancer drugs.
Clement, Lin, Danzhou, Yang
openaire +2 more sources
Epigenetics, 2021 The presence of 5-hydroxymethyl cytosine in DNA has been previously associated with ageing. Using in silico analysis of normal liver samples we presently observed that in 5-hydroxymethyl cytosine sequences, DNA methylation is dependent on the co-presence
Andigoni Malousi +2 more
doaj +1 more source
NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2019 G-quadruplexes are noncanonical, four-stranded nucleic acid secondary structures formed in sequences containing consecutive runs of guanines. These G-quadruplex structures have been found to form in nucleic acid regions of biological significance, including human telomeres, gene promoters, and untranslated regions of mRNA.
Clement, Lin +2 more
openaire +2 more sources
Unraveling G‐Quadruplex and i‐Motif Coexistence Within a Double‐Stranded DNA
Angewandte Chemie, EarlyView.The relative thermodynamic profiles of G‐quadruplex (G4), i‐Motif (iM), and the duplex counterpart tune the simultaneous G4 and iM formation within a double‐stranded (ds) DNA. ABSTRACT DNA can transiently fold into variable arrangements, which are expected to exploit regulatory functions. Guanine‐rich sequences can fold into G‐quadruplexes (G4s), while
Davide Auricchio +7 more
wiley +2 more sources