Results 11 to 20 of about 9,085,971 (219)

Structure and Function of Multimeric G-Quadruplexes [PDF]

Molecules, 2019
G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine tetrads. They are frequently used as building blocks and functional elements in fields such as synthetic biology and also thought to play widespread biological roles.
Sofia Kolesnikova, Edward A. Curtis
doaj   +4 more sources

G-Quadruplexes as Sensing Probes [PDF]

Molecules, 2013
Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding.
Branislav Ruttkay-Nedecky, Jiri Kudr, Lukas Nejdl, Darina Maskova, Rene Kizek, Vojtech Adam   +5 more
doaj   +5 more sources

RNA G-quadruplexes: G-quadruplexes with “U” turns

Current Pharmaceutical Design, 2012
G-quadruplexes are non canonical secondary structures held together by Hoogsteen bonded planar guanine quartets formed in G-rich sequences in DNA and RNA.
Prakash Pandey, Satya, Maiti, Souvik, Agarwala, Prachi, Jayaraj, Gopal, Agarwal, Tani   +4 more
core   +3 more sources

Stability of telomeric G-quadruplexes [PDF]

Nucleic Acids Research, 2010
In most eukaryotes, telomeric DNA consists of repeats of a short motif that includes consecutive guanines and may hence fold into G-quadruplexes.
Mergny, Jean-Louis, Patrizia Alberti, Phong Lan Thao Tran, Alberti, Patrizia, Jean-louis Mergny, Thao Tran, Phong Lan, Tran, Phong Lan Thao   +7 more
core   +4 more sources

Profusion of G-quadruplexes on both subunits of metazoan ribosomes.

PLoS ONE, 2019
Mammalian and bird ribosomes are nearly twice the mass of prokaryotic ribosomes in part because of their extraordinarily long rRNA tentacles. Human rRNA tentacles are not fully observable in current three-dimensional structures and their conformations ...
Santi Mestre-Fos, Petar I Penev, John Colin Richards, William L Dean, Robert D Gray, Jonathan B Chaires, Loren Dean Williams   +6 more
doaj   +2 more sources

Integrative characterization of G-Quadruplexes in the three-dimensional chromatin structure

Epigenetics, 2019
DNA molecules are highly compacted in the eukaryotic nucleus where distal regulatory elements reach their targets through three-dimensional chromosomal interactions.
Yue Hou, Fuyu Li, Rongxin Zhang, Sheng Li, Hongde Liu, Zhaohui S. Qin, Xiao Sun   +6 more
doaj   +3 more sources

G-Quadruplexes at Telomeres: Friend or Foe?

Molecules, 2020
Telomeres are DNA-protein complexes that cap and protect the ends of linear chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short tandem repeats of the G-rich strand have the capacity to form into secondary structures in ...
Tracy M. Bryan
doaj   +2 more sources

G‐quadruplexes in RNA biology

WIREs RNA, 2012
International audienceAbstract G‐quadruplexes are noncanonical structures formed by G‐rich DNA and RNA sequences that fold into a four‐stranded conformation.
Millevoi, Stefania, Vagner, Stéphan, Stefania Millevoi, Stéphan Vagner, Hervé Moine, Moine, Hervé   +5 more
core   +3 more sources

G-quadruplexes self-assembled from nucleotide monomers as stable prepolymer scaffolds in aqueous environments [PDF]

Scientific Reports
Life is composed of genetic and functional polymers, such as nucleic acids. For life to have emerged, a prebiotic mechanism for assembling these polymers is essential.
Simon H. J. Eiby, Thomas E. Catley, Max C. Gamill, Alice L. B. Pyne, Tue Hassenkam   +4 more
doaj   +2 more sources

G-Quadruplexes in Human Telomere: Structures, Properties, and Applications [PDF]

Molecules, 2023
G-quadruplexes, intricate four-stranded structures composed of G-tetrads formed by four guanine bases, are prevalent in both DNA and RNA. Notably, these structures play pivotal roles in human telomeres, contributing to essential cellular functions ...
Yan Xu, Makoto Komiyama
doaj   +2 more sources