Results 11 to 20 of about 9,012 (187)
Microbiology Spectrum, 2022 Human enteroviruses cause many diseases; however, there is no specific therapeutic drug. G-quadruplex is an atypical secondary structure formed in the guanine rich region of DNA or RNA, which can exist in the viral genome.
Lu Lv, Leiliang Zhang
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G-Quadruplexes as Sensing Probes [PDF]
Molecules, 2013 Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding.
Branislav Ruttkay-Nedecky +5 more
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G-Quadruplexes and Their Ligands: Biophysical Methods to Unravel G-Quadruplex/Ligand Interactions [PDF]
Pharmaceuticals, 2021 Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of approaches that assess the binding mode and nature of the interactions between G4 forming sequences and their putative ligands. The experimental approaches used to characterize G4/ligand interactions can be categorized into structure-based methods (circular ...
Tiago Santos +3 more
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Heliyon, 2023 Nephrotic Syndrome is the most widespread pediatric kidney disorder. Genetic alterations in podocyte genes are thought to be responsible for the disease. G-quadruplexes are non-conventional guanine-rich DNA and RNA structures, which are commonly found in
Mona Saad +2 more
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Frontiers in Chemistry, 2021 G-quadruplexes are believed to have important biological functions, so many small molecules have been screened or developed for targeting G-quadruplexes.
Xiao-Xia Hu +12 more
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G-Quadruplexes in the Archaea Domain [PDF]
Biomolecules, 2020 The importance of unusual DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, G-quadruplexes (G4s) have gained in popularity during the last decade, and their presence and functional relevance at the DNA and RNA level has been demonstrated in a number of viral, bacterial ...
Václav Brázda +13 more
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Pharmaceutics, 2022 G-quadruplexes turned out to be important targets for the development of novel targeted anticancer/antiviral therapies. More than 3000 G-quadruplex small-molecule ligands have been described, with most of them exerting anticancer/antiviral activity by ...
Andrea Criscuolo +5 more
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G-quadruplexes and helicases [PDF]
Nucleic Acids Research, 2016 Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as 'knots' within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures.
Mendoza, Oscar +4 more
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Pressure Perturbation Studies of Noncanonical Viral Nucleic Acid Structures
Biology, 2021 G-quadruplexes are noncanonical structures formed by guanine-rich sequences of the genome. They are found in crucial loci of the human genome, they take part in the regulation of important processes like cell proliferation and cell death.
Judit Somkuti +3 more
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