Results 41 to 50 of about 29,743 (315)
Discovery of G-quadruplex-forming sequences in SARS-CoV-2
Briefings Bioinform., 2020 The outbreak caused by the novel coronavirus SARS-CoV-2 has been declared a global health emergency. G-quadruplex structures in genomes have long been considered essential for regulating a number of biological processes in a plethora of organisms.
Danyang Ji +5 more
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PLoS ONE, 2022 GW-2974 is a potent tyrosine kinase receptor inhibitor while SCH-442416 is a potent adenosine receptors' antagonist with high selectivity towards human adenosine A2A receptor over other adenosine receptors. The two compounds were reported to possess anti-
Alaa A Salem +2 more
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Molbank, 2010 Cationic porphyrins interact strongly with guanine quadruplex DNA (G-quadruplex). We herein report the preparation of a cationic porphyrin bearing quinolinium side arms, 1,1’,1’’,1’’’-[porphyrin-5,10,15,20-tetrayltetrakis(3,1-phenylenemethylene)]tetra ...
Satoshi Fujii +3 more
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Frontiers in Microbiology, 2020 3′,5′ Cyclic diguanylic acid (c-di-GMP) has been shown to play a central role in the regulation of bacterial physiological processes such as biofilm formation and virulence production, and is regarded as a potential target for the development of anti ...
Teng-Fei Xuan +4 more
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I-MOTIF DNA: SIGNIFICANCE AND FUTURE PROSPECTIVE [PDF]
Exploratory Animal and Medical Research, 2020 Since the first report of its existence emerged in the early 1990s, i-motif DNA has gained much interest among the other non-canonical DNA structures in recent years.
Sushmita Nautiyal +5 more
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Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids
Pharmaceuticals, 2021 The role of G-quadruplexes in human cancers is increasingly well-defined. Accordingly, G-quadruplexes can be suitable drug targets and many small molecules have been identified to date as G-quadruplex binders, some using computer-based design methods and
Stephen Neidle
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The Targeting of Quadruplex Nucleic Acids in Human Cancers
Proceedings, 2019 The overwhelming majority of DNA in the human genome is double-stranded. However,regions comprising several short guanine-tracts are capable of forming higher-order structures,termed quadruplexes. [...]
Stephen Neidle
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Crucial Role of the C-Terminal Domain of Hfq Protein in Genomic Instability
Microorganisms, 2020 G-rich DNA repeats that can form G-quadruplex structures are prevalent in bacterial genomes and are frequently associated with regulatory regions of genes involved in virulence, antigenic variation, and antibiotic resistance.
Virali J. Parekh +5 more
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A guide to computational methods for G-quadruplex prediction
Nucleic Acids Research, 2019 Guanine-rich nucleic acids can fold into the non-B DNA or RNA structures called G-quadruplexes (G4). Recent methodological developments have allowed the characterization of specific G-quadruplex structures in vitro as well as in vivo, and at a much ...
E. P. Puig Lombardi, A. Londoño-Vallejo
semanticscholar +1 more source
G-quadruplex based biosensor: A potential tool for SARS-CoV-2 detection
Biosensors & bioelectronics, 2020 G-quadruplex is a non-canonical nucleic acid structure formed by the folding of guanine rich DNA or RNA. The conformation and function of G-quadruplex are determined by a number of factors, including the number and polarity of nucleotide strands, the ...
Hui Xi, M. Juhas, Yang Zhang
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