Results 21 to 30 of about 39,952 (313)

Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity [PDF]

, 2013
G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome.
Frasson, Ilaria, Nadai, Matteo, Palumbo, Manlio, Palù, Giorgio, Perrone, Rosalba, Poe, Jerrod A., Qiu, Jianming, Richter, Sara N., Smithgall, Thomas E.   +8 more
core   +2 more sources

Conserved presence of G-quadruplex forming sequences in the Long Terminal Repeat Promoter of Lentiviruses [PDF]

, 2017
G-quadruplexes (G4s) are secondary structures of nucleic acids that epigenetically regulate cellular processes. In the human immunodeficiency lentivirus 1 (HIV-1), dynamic G4s are located in the unique viral LTR promoter.
A Ayouba, A Henderson, A Rambaut, AK Todd, AM Fleming, AN Lane, AR Haeusler, B Berkhout, B Zhou, BF Keele, D Piekna-Przybylska, D Qu, D Rhodes, D Sen, DJ Patel, E Tosoni, EA Raiber, F Barre-Sinoussi, F Benachenhou, F Bibollet-Ruche, F Heuverswyn Van, F Turrini, G Biffi, GE Crooks, IT Holder, J Felsenstein, J Norseen, J Qiu, J Song, J Yamaguchi, JE Clements, JF Fisette, JP Taylor, K Tamura, K Tluckova, KA Jones, LA Pereira, M Fry, M Metifiot, M Sala, M Scalabrin, MA Larkin, N Maizels, ND Perkins, NH Campbell, P Fratta, P Ivanov, P Murat, P Sket, R Perrone, R Perrone, R Perrone, R Perrone, RC Edgar, RC Gallo, RJ Gifford, S Amrane, S Artusi, S Artusi, S Balasubramanian, S Bhatia, S Broos, S Burge, S Pohlmann, SE Tong-Starksen, SR Wang, SR Wang, Y Wang   +67 more
core   +1 more source

High-Resolution Three-Dimensional NMR Structure Of The KRAS Proto-Oncogene Promoter Reveals Key Features Of A G-Quadruplex Involved In Transcriptional Regulation [PDF]

, 2017
Non-canonical base pairing within guanine-rich DNA and RNA sequences can produce G-quartets, whose stacking leads to the formation of a G-quadruplex (G4).
Ivashchenko, S., Kerkour, A., Marquevielle, J., Mergny, J.-L., Salgado, G. F., Yatsunyk, Liliya A.   +5 more
core   +2 more sources

Activity of Human Apurinic/Apyrimidinic Endonuclease APE1 Toward Damaged DNA and Native RNA With Non-canonical Structures

Frontiers in Cell and Developmental Biology, 2020
The primary role of apurinic/apyrimidinic (AP) endonuclease APE1 in human cells is the cleavage of the sugar phosphate backbone 5′ to an AP site in DNA to produce a single-strand break with a 5′-deoxyribose phosphate and 3′-hydroxyl end groups.
Anastasia T. Davletgildeeva, Anastasia T. Davletgildeeva, Alexandra A. Kuznetsova, Olga S. Fedorova, Nikita A. Kuznetsov   +4 more
doaj   +1 more source

Theoretical Assessment of the Ligand/Metal/Quadruplex Recognition in the Non-Canonical Nucleic Acids Structures

Molecules, 2023
Quadruplexes (GQs), peculiar DNA/RNA motifs concentrated in specific genomic regions, play a vital role in biological processes including telomere stability and, hence, represent promising targets for anticancer therapy. GQs are formed by folding guanine-
Nikoleta Kircheva, Stefan Dobrev, Vladislava Petkova, Snezhana Bakalova, Jose Kaneti, Silvia Angelova   +5 more
doaj   +1 more source

Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome [PDF]

, 2016
open8The long terminal repeat (LTR) of the proviral human immunodeficiency virus (HIV)-1 genome is integral to virus transcription and host cell infection.

core   +1 more source

Why are G-quadruplexes good at preventing protein aggregation?

RNA Biology, 2023
Maintaining a healthy protein folding environment is essential for cellular function. Recently, we found that nucleic acids, G-quadruplexes in particular, are potent chaperones for preventing protein aggregation.
Theodore J. Litberg, Rajesh Kumar Reddy Sannapureddi, Zijue Huang, Ahyun Son, Bharathwaj Sathyamoorthy, Scott Horowitz   +5 more
doaj   +1 more source

Non-G Base Tetrads

Molecules, 2022
Tetrads (or quartets) are arrangements of four nucleobases commonly involved in the stability of four-stranded nucleic acids structures. Four-stranded or quadruplex structures have attracted enormous attention in the last few years, being the most ...
Núria Escaja, Bartomeu Mir, Miguel Garavís, Carlos González   +3 more
doaj   +1 more source

Conformational profiling of a G-rich sequence within the c-KIT promoter [PDF]

, 2017
G-quadruplexes (G4) within oncogene promoters are considered to be promising anticancer targets. However, often they undergo complex structural rearrangements that preclude a precise description of the optimal target.
Chaires, Jonathan B, Dean, William L, Gray, Robert D, Rigo, Riccardo, Sissi, Claudia   +4 more
core   +1 more source

DNA and RNA Quadruplex ligands [PDF]

Nucleic Acids Symposium Series, 2008
Guanine-rich nucleic acids can adopt unusual structures called guanine quadruplexes (G4) based on stacked guanine quartets. Both RNA and DNA backbones are compatible with G4 formation. As RNA and DNA quadruplexes may be recognized by ligands, it is important to understand the rules that govern the stability and specificity of these complexes.
De Cian, Anne, Gros, Julien, Guédin, Aurore, Haddi, Meriem, Lyonnais, Sébastien, Guittat, Lionel, Riou, Jean-François, Trentesaux, Chantal, Sacca, Barbara, Lacroix, Laurent, Alberti, Patrizia, Mergny, Jean-Louis   +11 more
openaire   +3 more sources