Results 21 to 30 of about 23,522 (167)

Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound

, 2016
Inhibition of Human Telomerase by a G-Quadruplex-Interactive ...
Daekyu Sun (11744), Stephen Neidle (9285), Brian E. Cathers (1562323), John O. Trent (10613), Sean M. Kerwin (2180086), Terence C. Jenkins (1734115), Laurence H. Hurley (11747), Miguel Salazar (2693188), Brian Thompson (169977)   +8 more
core   +1 more source

Vibrational spectroscopy simulation of solvation effects on a G-quadruplex

, 2023
It is commonly believed that solvation effects on the vibrational properties of a solute are easily accounted for by simple rules of thumbs, that is, solvating a polar molecule in a polar medium has the only effect of red shifting all its spectroscopical
Fabio Gabas (1976041), Michele Ceotto (1373325), Davide Moscato (14699494), Riccardo Conte (1373322)   +3 more
core   +1 more source

Binding of malachite green promotes stability and shows preference for a human telomere DNA G-quadruplex

, 2017
A single-stranded human telomere DNA sequence can fold into an intramolecular G-quadruplex structure, which has been shown to inhibit telomerase activity. Small molecules that selectively target and stabilise the G-quadruplex structure have been proposed
Takashi Matsui (752618), Ryoko M. Uda (2084152), Michiko Takei (3823720)   +2 more
core   +1 more source

Quadruplex-Flanking Stem Structures Modulate the Stability and Metal Ion Preferences of RNA Mimics of GFP

, 2016
The spinach family of RNA aptamers are RNA mimics of green fluorescent protein (GFP) that have previously been designed to address the challenges of imaging RNA inside living cells.
Kushal J. Rohilla (2900672), Eman A. Ageely (2900681), Zachary J. Kartje (2900678), Keith T. Gagnon (2147668), Christopher L. Barkau (2900675)   +4 more
core   +1 more source

Design and Synthesis of the G-Quadruplex-Specific Cleaving Reagent Perylene-EDTA·Iron(II)

, 2016
Design and Synthesis of the G-Quadruplex-Specific Cleaving Reagent Perylene-EDTA·Iron ...
Jeong Tae Lee (2140111), Wirote Tuntiwechapikul (2946165), Miguel Salazar (2693188)   +2 more
core   +1 more source

Green Layer-by-Layer Assembly of Porphyrin/G-Quadruplex-Based Near-Infrared Nanocomposite Photosensitizer with High Biocompatibility and Bioavailability

, 2020
A simple and green layer-by-layer assembly strategy is developed for the preparation of a highly bioavailable nanocomposite photosensitizer by assembling near-infrared (NIR) light-sensitive porphyrin/G-quadruplex complexes on the surface of a highly ...
Peng-Fei Lang (8384877), Rong-Zhi Gao (8384871), Cheng-Guang Gu (8384874), Rong-Zhi Gao, Li-Ming Zhang (490194), De-Ming Kong, Jun-Qing Chu (8384868), De-Ming Kong (162887), Dong-Xia Wang, Pei-Qi Liu (8384880), Li-Na Zhu (162874), Li-Na Zhu, Li-Ming Zhang, Dong-Xia Wang (6503441), Cheng-Guang Gu, Meng Cheng (1650886), Jun-Qing Chu, Meng Cheng, Peng-Fei Lang, Pei-Qi Liu   +19 more
core   +1 more source

A G-rich sequence within the 3'UTR of KiSS1 forms G-quadruplex [PDF]

, 2022
L’obiettivo dello studio è stato quello di dimostrare che la regione ricca in guanine del 3’UTR del gene KiSS1 forma effettivamente strutture secondarie G-quadruplex e di capire se i polimorfismi trovati nei pazienti affetti da pubertà precoce ...
Bonafè, Giulia
core  

Quadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formation [PDF]

Nucleic Acids Research, 2007
G-quadruplexes are a family of four-stranded DNA structures, stabilized by G-quartets, that form in the presence of monovalent cations. Efforts are currently being made to identify ligands that selectively bind to G-quadruplex motifs as these compounds may interfere with the telomere structure, telomere elongation/replication and proliferation of ...
Cian, Anne De, Mergny, Jean-Louis
openaire   +2 more sources

Binding mode of a cationic porphyrin to parallel and antiparallel thrombin binding aptamer G-quadruplex

, 2019
The spectral properties of meso-tetrakis (N-methylpyridinium-4-yl)porphyrin (TMPyP) in the presence of parallel and antiparallel G-quadruplexes formed from a thrombin-binding aptamer G-quadruplex (5′-G3T2G3TGTG3T2G3) were investigated in this study.
Young-Ae Lee (177248), Yoon Jung Jang (1921081), Ye Sol Oh (4444555), Gil Jun Lee (7157891), Ha Young Cho (7157888), Seog K. Kim (1921084)   +5 more
core   +1 more source

Additional file 7: Table S5. of Recombination events among virulence genes in malaria parasites are associated with G-quadruplex-forming DNA motifs

, 2016
Putative G-quadruplex-forming sequences in the P. reichenowi CDC genome. Genome searched using ‘QGRS Mapper’ [35] with the parameters G3 N(0–11) G3 N(0–11) G3 N(0–11) G3 [17].
Adam Stanton (3455450), Catherine Merrick (3455447), Gemma Graham (719041), Lynne Harris (3455453)   +3 more
core   +1 more source