Results 21 to 30 of about 29,743 (315)
Molecules, 2020 The stabilisation of G-quadruplexes (G4s) by small-molecule compounds is an effective approach for causing cell growth arrest, followed by cell death. Some of these compounds are currently being developed for the treatment of human cancers.
Ahmed Abdullah Ahmed, Stephen Neidle
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Engineering Proceedings, 2023 Pathogens can be detected electrochemically by measuring guanine oxidation signals generated from RNA or DNA hybridized to a biosensor working electrode. However, the associated limit of detection (LOD) is not sufficiently low for widespread clinical use.
Neil Gordon, Raj Bawa, Garry Palmateer
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Quantitative Visualization of DNA G-quadruplex Structures in Human Cells
Nature Chemistry, 2013 Four-stranded G-quadruplex nucleic acid structures have been of great interest as their high thermodynamic stability under near-physiological conditions suggests that they could form in cells.
Giulia Biffi +3 more
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Quadruplex DNA: sequence, topology and structure
Nucleic Acids Research, 2006 G-quadruplexes are higher-order DNA and RNA structures formed from G-rich sequences that are built around tetrads of hydrogen-bonded guanine bases. Potential quadruplex sequences have been identified in G-rich eukaryotic telomeres, and more recently in ...
Sarah W. Burge +4 more
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Journal of the American Chemical Society, 2021 Liquid-liquid phase separation (LLPS) of proteins and DNA has recently emerged as a possible mechanism underlying the dynamic organization of chromatin.
M. Mimura +7 more
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G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2011 G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. DNA G-quadruplexes have recently emerged as attractive cancer therapeutic targets. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures.
Raveendra I, Mathad, Danzhou, Yang
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On the Road to Fight Cancer: The Potential of G-Quadruplex Ligands as Novel Therapeutic Agents
International Journal of Molecular Sciences, 2021 Nucleic acid sequences able to adopt a G-quadruplex conformation are overrepresented within the human genome. This evidence strongly suggests that these genomic regions have been evolutionary selected to play a pivotal role in several aspects of cell ...
Irene Alessandrini +3 more
semanticscholar +1 more source
Molecules, 2023 Quadruplexes (GQs), peculiar DNA/RNA motifs concentrated in specific genomic regions, play a vital role in biological processes including telomere stability and, hence, represent promising targets for anticancer therapy. GQs are formed by folding guanine-
Nikoleta Kircheva +5 more
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DNA and RNA Quadruplex ligands [PDF]
Nucleic Acids Symposium Series, 2008 Guanine-rich nucleic acids can adopt unusual structures called guanine quadruplexes (G4) based on stacked guanine quartets. Both RNA and DNA backbones are compatible with G4 formation. As RNA and DNA quadruplexes may be recognized by ligands, it is important to understand the rules that govern the stability and specificity of these complexes.
De Cian, Anne +11 more
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Frontiers in Cell and Developmental Biology, 2020 The primary role of apurinic/apyrimidinic (AP) endonuclease APE1 in human cells is the cleavage of the sugar phosphate backbone 5′ to an AP site in DNA to produce a single-strand break with a 5′-deoxyribose phosphate and 3′-hydroxyl end groups.
Anastasia T. Davletgildeeva +4 more
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