Role of the central cations in the mechanical unfolding of DNA and RNA G-quadruplexes. [PDF]
, 2015 Cations are known to mediate diverse interactions in nucleic acids duplexes but they are critical in the arrangement of four-stranded structures. Here, we use all-atom molecular dynamics simulations with explicit solvent to analyse the mechanical ...
Bergues-Pupo, AE +25 more
core +1 more source
, 2016 Telomestatin is a natural product isolated from Streptomyces anulatus 3533-SV4 and has been shown to be a very potent telomerase inhibitor. The structural similarity between telomestatin and a G-tetrad suggested to us that the telomerase inhibition might
Kazuo Shin-ya (133016) +4 more
core +2 more sources
G-Quadruplexes and Their Ligands: Biophysical Methods to Unravel G-Quadruplex/Ligand Interactions [PDF]
Pharmaceuticals, 2021 Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of approaches that assess the binding mode and nature of the interactions between G4 forming sequences and their putative ligands. The experimental approaches used to characterize G4/ligand interactions can be categorized into structure-based methods (circular ...
Tiago Santos +3 more
openaire +4 more sources
Colorimetric Detection of S1 Nuclease Activity using a Hairpin DNA with Split G-Quadruplex
, 2023 Hairpin DNA containing split G-quadruplex at its terminus displayed tagging position-dependent horseradish peroxidase activity. In general, the hairpin DNA coupled with one GGG repeat at its 5’-terminus and three GGG repeats at its 3′-terminus ...
Kunqi Cheng (14970967) +7 more
core +1 more source
Investigation of the guanine quadruplex resolving activity of the DEAH-box RNA helicase RHAU [PDF]
, 2012 Generally depicted as single- or double-stranded molecules, nucleic acids sequences can adopt various forms of stable secondary structures. In particular, guanine-riche sequence of DNA and RNA can form atypical four-stranded helical structures termed G ...
Lattmann, Simon
core +1 more source
A role for non-B DNA forming sequences in mediating microlesions causing human inherited disease [PDF]
, 2015 Missense/nonsense mutations and micro-deletions/micro-insertions of
Kamat, MA +7 more
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The effect of oxidation on the stability of G-quadruplex DNA : implications for oncogene expression [PDF]
, 2011 G-quadruplexes (G4-DNA) are a class of secondary structures formed from Guanine rich sequences. In recent years these structures have been implicated in both telomere maintenance and oncogene expression, and have been shown to be abundant in upstream ...
Stebbeds, William Joshua David
core
A G-rich sequence within the 3'UTR of KiSS1 forms G-quadruplex [PDF]
, 2010 L’obiettivo dello studio è stato quello di dimostrare che la regione ricca in guanine del 3’UTR del gene KiSS1 forma effettivamente strutture secondarie G-quadruplex e di capire se i polimorfismi trovati nei pazienti affetti da pubertà precoce ...
Bonafè, Giulia
core
Toward Artificial Ion Channels: A Lipophilic G-Quadruplex
, 2016 Single crystals of a lipophilic G-quadruplex formed by 5‘-tert-butyl-dimethylsilyl-2‘,3‘,-di-O-isopropylidene G 2 were obtained from a CH3CN solution containing potassium picrate and cesium picrate.
Silvia Pieraccini (2137432) +4 more
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G-Quadruplex-Specific Peptide−Hemicyanine Ligands by Partial Combinatorial Selection
, 2016 G-quadruplex DNA-specific ligands were generated using a combinatorial selection of tetrapeptides which were then conjugated to a hemicyanine scaffold. The heterocycle enhanced peptide binding affinity by ∼1000-fold to give ligands with near micromolar ...
Shankar Balasubramanian (9301) +4 more
core +1 more source