Results 31 to 40 of about 29,743 (315)
Why are G-quadruplexes good at preventing protein aggregation?
RNA Biology, 2023 Maintaining a healthy protein folding environment is essential for cellular function. Recently, we found that nucleic acids, G-quadruplexes in particular, are potent chaperones for preventing protein aggregation.
Theodore J. Litberg +5 more
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Molecules, 2022 Tetrads (or quartets) are arrangements of four nucleobases commonly involved in the stability of four-stranded nucleic acids structures. Four-stranded or quadruplex structures have attracted enormous attention in the last few years, being the most ...
Núria Escaja +3 more
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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Nature Communications, 2017 G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in different cellular processes. Targeting G-quadruplex DNAs for cancer treatment is a very promising prospect.
Hong Xu +38 more
semanticscholar +1 more source
Polyelectrolyte effects in G-quadruplexes [PDF]
Biophysical Chemistry, 2013 The role of counterion condensation as a dominant force governing the stability of DNA duplexes and triplexes is well established. In contrast, the effect of counterion condensation on the stability of G-quadrupex conformations is poorly understood. Unlike other ordered nucleic acid structures, G-quadruplexes exhibit a specific binding of counterions ...
Kim, Byul +2 more
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Biomolecules, 2023 Increased expression of the human telomere reverse transcriptase (hTERT) in tumors promotes tumor cell survival and diminishes the survival of patients.
James W. Conrad +6 more
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G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders
Nucleic Acids Research, 2020 Genomic DNA and cellular RNAs can form a variety of non-B secondary structures, including G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held together by Hoogsteen hydrogen bonds and can form at key regulatory sites of ...
G. Miglietta, Marco Russo, G. Capranico
semanticscholar +1 more source
Re-evaluation of G-quadruplex propensity with G4Hunter
Nucleic Acids Research, 2016 Critical evidence for the biological relevance of G-quadruplexes (G4) has recently been obtained in seminal studies performed in a variety of organisms.
Amina Bedrat, L. Lacroix, J. Mergny
semanticscholar +1 more source
Control of the polyamine biosynthesis pathway by G2-quadruplexes
eLife, 2018 G-quadruplexes are naturally-occurring structures found in RNAs and DNAs. Regular RNA G-quadruplexes are highly stable due to stacked planar arrangements connected by short loops.
Helen Louise Lightfoot +4 more
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Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy
Molecules, 2019 A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-rich sequences, and has profound implications for various pharmacological and biological events, including cancers.
Sefan Asamitsu +4 more
semanticscholar +1 more source
G4Hunter web application: a web server for G-quadruplex prediction
Bioinform., 2019 Motivation Expanding research highlights the importance of guanine quadruplex structures. Therefore, easy-accessible tools for quadruplex analyses in DNA and RNA molecules are important for the scientific community.
V. Brázda +6 more
semanticscholar +1 more source