Results 21 to 30 of about 13,196,617 (310)
RNA G-quadruplex structure contributes to cold adaptation in plants
bioRxiv, 2022 Nucleotide composition is suggested to infer gene functionality and ecological adaptation of species to distinct environments. However, the underlying biological function of nucleotide composition dictating environmental adaptations is largely unknown ...
Xiaofei Yang +9 more
semanticscholar +1 more source
Polyelectrolyte effects in G-quadruplexes [PDF]
Biophysical Chemistry, 2013 The role of counterion condensation as a dominant force governing the stability of DNA duplexes and triplexes is well established. In contrast, the effect of counterion condensation on the stability of G-quadrupex conformations is poorly understood. Unlike other ordered nucleic acid structures, G-quadruplexes exhibit a specific binding of counterions ...
Kim, Byul +2 more
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G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2011 G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. DNA G-quadruplexes have recently emerged as attractive cancer therapeutic targets. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures.
Raveendra I, Mathad, Danzhou, Yang
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Aminoglycosylation can enhance the G-quadruplex binding activity of epigallocatechin. [PDF]
PLoS ONE, 2013 With the aim of enhancing G-quadruplex binding activity, two new glucosaminosides (16, 18) of penta-methylated epigallocatechin were synthesized by chemical glycosylation.
Li-Ping Bai +5 more
doaj +1 more source
Multistep mechanism of G-quadruplex resolution during DNA replication
Science Advances, 2021 DNA helicases DHX36 and FANCJ constitute a previously unknown pathway that resolves G-quadruplex structures during DNA replication.
Koichi Sato +4 more
semanticscholar +1 more source
Computational studies of the interactions between quinazolone derivatives and G-quadruplex DNA as an anticancer strategy [PDF]
شیمی کاربردی روز, 2015 In recent years, stabilization of G-quadruplex structures with small molecules has attracted considerable attentions as a promising target for cancer therapy.
Kiana Gholamjani Moghaddam +1 more
doaj +1 more source
Quantitative Visualization of DNA G-quadruplex Structures in Human Cells
Nature Chemistry, 2013 Four-stranded G-quadruplex nucleic acid structures have been of great interest as their high thermodynamic stability under near-physiological conditions suggests that they could form in cells.
Giulia Biffi +3 more
semanticscholar +1 more source
G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]
Nucleic Acids Research, 2018 G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in recent years the presence of G4s in viruses has attracted increasing interest.
Emanuela Ruggiero, Sara N Richter
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G-quadruplexes in helminth parasites
Nucleic Acids Research, 2022 Abstract Parasitic helminths infecting humans are highly prevalent infecting ∼2 billion people worldwide, causing inflammatory responses, malnutrition and anemia that are the primary cause of morbidity. In addition, helminth infections of cattle have a significant economic impact on livestock production, milk yield and fertility.
Cantara, Alessio +13 more
openaire +3 more sources
On the Road to Fight Cancer: The Potential of G-Quadruplex Ligands as Novel Therapeutic Agents
International Journal of Molecular Sciences, 2021 Nucleic acid sequences able to adopt a G-quadruplex conformation are overrepresented within the human genome. This evidence strongly suggests that these genomic regions have been evolutionary selected to play a pivotal role in several aspects of cell ...
Irene Alessandrini +3 more
semanticscholar +1 more source