Results 41 to 50 of about 13,196,617 (310)

Human Telomeric G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]

, 2017
G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures, and the human telomeric DNA G-quadruplexes are considered attractive targets for anticancer drugs.
Clement, Lin, Danzhou, Yang
openaire   +2 more sources

Synthesis of copper (II) porphyrin complexes and their interaction with c-myc G-quadruplex DNA

Journal of Holistic Integrative Pharmacy, 2021
Objective: To synthesize copper (II) porphyrin complexes and study their interactions with c-myc G-quadruplex DNA. Methods: The 5-p-hydroxyphenyl-10, 15, 20-tris (p-methoxyphenyl) copper (II) porphyrin complex [p-HTMOPPCu (II)] was synthesized by the ...
Kunxian YANG, Jiashu CHEN, Bingbing ZHAI, Weiming CHEN, Huanglan YANG, Yufen XIAO, Juping WANG, Wenjie MEI   +7 more
doaj   +1 more source

Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues.

PLoS ONE, 2014
Four-stranded G-quadruplex DNA secondary structures have recently been visualized in the nuclei of human cultured cells. Here, we show that BG4, a G-quadruplex-specific antibody, can be used to stain DNA G-quadruplex structures in patient-derived tissues
Giulia Biffi, David Tannahill, Jodi Miller, William J Howat, Shankar Balasubramanian   +4 more
doaj   +1 more source

Bisquinolinium compounds induce quadruplex-specific transcriptome changes in HeLa S3 cell lines

BMC Research Notes, 2012
Background Guanosine rich sequences capable of forming G-quadruplex (G4) motifs are enriched near the gene transcription start site (TSS) in the human genome.
Halder Rashi, Riou Jean-Francois, Teulade-Fichou Marie-Paule, Frickey Tancred, Hartig Jörg S   +4 more
doaj   +1 more source

The Interaction of Cyclic Naphthalene Diimide with G-Quadruplex under Molecular Crowding Condition

Molecules, 2020
G-quadruplex specific targeting molecules, also termed as G4 ligands, are attracting increasing attention for their ability to recognize and stabilize G-quadruplex and high potentiality for biological regulation.
Tingting Zou, Shinobu Sato, Rui Yasukawa, Ryusuke Takeuchi, Shunsuke Ozaki, Satoshi Fujii, Shigeori Takenaka   +6 more
doaj   +1 more source

G-Quadruplexes Involving Both Strands of Genomic DNA Are Highly Abundant and Colocalize with Functional Sites in the Human Genome. [PDF]

PLoS ONE, 2016
The G-quadruplex is a non-canonical DNA structure biologically significant in DNA replication, transcription and telomere stability. To date, only G4s with all guanines originating from the same strand of DNA have been considered in the context of the ...
Andrzej S Kudlicki
doaj   +1 more source

NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]

, 2019
G-quadruplexes are noncanonical, four-stranded nucleic acid secondary structures formed in sequences containing consecutive runs of guanines. These G-quadruplex structures have been found to form in nucleic acid regions of biological significance, including human telomeres, gene promoters, and untranslated regions of mRNA.
Clement, Lin, Jonathan, Dickerhoff, Danzhou, Yang   +2 more
openaire   +2 more sources

Development of Fluorescent Aptasensors Based on G-Quadruplex Quenching Ability for Ochratoxin A and Potassium Ions Detection

Biosensors, 2022
G-quadruplexes have received significant attention in aptasensing due to their structural polymorphisms and unique binding properties. In this work, we exploited the fluorescence-quenching properties of G-quadruplex to develop a simple, fast, and ...
Cheng Yang, Xiaolin Chu, Li Zeng, Amina Rhouati, Fathimath Abbas, Shengnan Cui, Daiqin Lin   +6 more
doaj   +1 more source

Stability of telomeric G-quadruplexes [PDF]

Nucleic Acids Research, 2010
In most eukaryotes, telomeric DNA consists of repeats of a short motif that includes consecutive guanines and may hence fold into G-quadruplexes. Budding yeasts have telomeres composed of longer repeats and show variation in the degree of repeat homogeneity. Although telomeric sequences from several organisms have been shown to fold into G-quadruplexes
Tran, Phong Lan Thao, Mergny, Jean-Louis, Alberti, Patrizia   +2 more
openaire   +3 more sources

Discovery of G-quadruplex-forming sequences in SARS-CoV-2

Briefings Bioinform., 2020
The outbreak caused by the novel coronavirus SARS-CoV-2 has been declared a global health emergency. G-quadruplex structures in genomes have long been considered essential for regulating a number of biological processes in a plethora of organisms.
Danyang Ji, M. Juhas, C. Tsang, C. Kwok, Yongshu Li, Yang Zhang   +5 more
semanticscholar   +1 more source