Results 51 to 60 of about 32,953 (312)

G-quadruplex DNA aptamers and their ligands: Structure, function and application [PDF]

, 2012
Highly specific and tight-binding nucleic acid aptamers have been selected against a variety of molecular targets for over 20 years. A significant proportion of these oligonucleotides display G-quadruplex structures, particularly for DNA aptamers, that ...
Shum, KT, Tanner, JA, Tucker, WO
core   +1 more source

Kinetics and thermodynamics of G-quadruplexes [PDF]

Nucleic Acids Symposium Series, 2005
The melting of tetramolecular DNA or RNA quadruplexes is kinetically irreversible. However, rather than being a hindrance, this kinetic inertia allows us to study association and dissociation processes independently. General rules have been extended to longer DNA motifs or sequences containing modified bases such as 8-oxo or 7-deaza guanine.
Julien, Gros, Mateus, Webba da Silva, Anne, De Cian, Samir, Amrane, Frédéric, Rosu, Anne, Bourdoncle, Barbara, Saccà, Patrizia, Alberti, Laurent, Lacroix, Jean-Louis, Mergny   +9 more
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Rudimentary G-Quadruplex-Based Telomere Capping In Saccharomyces Cerevisiae [PDF]

, 2011
Telomere capping conceals chromosome ends from exonucleases and checkpoints, but the full range of capping mechanisms is not well defined. Telomeres have the potential to form G-quadruplex (G4) DNA, although evidence for telomere G4 DNA function in vivo ...
A De Cian, A Piazza, A Risitano, A Risitano, A Sfeir, AC Vallur, AN Lane, B Garvik, B Saccà, BR Linger, C Frei, C Ribeyre, CI Nugent, D Bonetti, D Gomez, DA Bernstein, David C Schultz, David Monchaud, EA Venczel, EP Mimitou, F Brad Johnson, H Ding, H Fernando, IM Pedroso, J Kypr, J Lin, J Lu, J Ren, J-L Mergny, JA Cobb, Jasmine S Smith, JD Frantz, John M Nicoludis, JR Mullen, JS Smith, K Förstemann, K Paeschke, L Maringele, L Oganesian, Lara Abramowitz, LD Nelson, Liliya A Yatsunyk, LL Sandell, M Downey, Marie-Paule Teulade-Fichou, Mark S Garcia, MD Huber, MD Huber, MD Vodenicharov, MK Zubko, MK Zubko, ML Kozak, ML Zhang, MW Van Dyke, N Grandin, N Hayashi, P Phatak, PM Watt, Qijun Chen, R Giraldo, Ramon Kranaster, RJ Michelson, S Burge, SG Addinall, SG Hershman, Shankar Balasubramanian, TR Salas, W Palm, Y Li, Y-C Tsai, Z Liu, Z Zhu   +71 more
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Interaction of pyrrolobenzodiazepine (PBD) ligands with parallel intermolecular G-quadruplex complex using spectroscopy and ESI-MS.

PLoS ONE, 2012
Studies on ligand interaction with quadruplex DNA, and their role in stabilizing the complex at concentration prevailing under physiological condition, has attained high interest.
Gajjela Raju, Ragampeta Srinivas, Vangala Santhosh Reddy, Mohammed M Idris, Ahmed Kamal, Narayana Nagesh   +5 more
doaj   +1 more source

Nanostructured luminescently labeled nucleic acids [PDF]

, 2017
Important and emerging trends at the interface of luminescence, nucleic acids and nanotechnology are: (i) the conventional luminescence labeling of nucleic acid nanostructures (e.g. DNA tetrahedron); (ii) the labeling of bulk nucleic acids (e.g. single‐
Adleman, Ai, Beater, Bi, Branton, Cao, Casini, Chen, Corstjens, Deng, Ding, Ding, Ding, Divsar, Du, Duan, Dunn, ENCODE, Fortina, Fortina, Gerling, Gommers-Ampt, Goodman, Han, He, He, He, He, He, Hembury, Heuer-Jungemann, Horikoshi, Hu, Huang, Jia, Ke, Kim, Knoblauch, Kricka, Kricka, Kwok, Lee, Li, Li, Lin, Liu, Liu, Liu, Lu, Ma, Maden, Mouse ENCODE Consortium, Nangreave, Nirenberg, Obliosca, Orbach, Ozhalici-Unal, Park, Park, Parker, Petty, Pinehiro, Randeria, Ren, Richards, Rijke, Ritchie, Rotaru, Rothemund, Seeman, Seferos, Severcan, Sharma, Shchepinov, Shen, Simonetti, Stahl, Stolper, Taton, Vanyushin, Vasudevan, Vummidi, Wang, Wang, Wang, Wang, Wang, Wang, Wu, Wu, Yan, Yang, Yang, Yang, Ye, Yeh, Yu, Yuan, Yurke, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zhou   +105 more
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The Presence and Localization of G-Quadruplex Forming Sequences in the Domain of Bacteria

Molecules, 2019
The role of local DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, the significance of G-quadruplexes was demonstrated in the last decade, and their presence and functional
Martin Bartas, Michaela Čutová, Václav Brázda, Patrik Kaura, Jiří Šťastný, Jan Kolomazník, Jan Coufal, Pratik Goswami, Jiří Červeň, Petr Pečinka   +9 more
doaj   +1 more source

RNA G-quadruplex structures exist and function in vivo in plants

Genome Biology, 2020
Background Guanine-rich sequences are able to form complex RNA structures termed RNA G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed to exist in vivo and are suggested to be associated with important biological ...
Xiaofei Yang, Jitender Cheema, Yueying Zhang, Hongjing Deng, Susan Duncan, Mubarak Ishaq Umar, Jieyu Zhao, Qi Liu, Xiaofeng Cao, Chun Kit Kwok, Yiliang Ding   +10 more
doaj   +1 more source

A Fragment-Based Approach for the Development of G-Quadruplex Ligands: Role of the Amidoxime Moiety [PDF]

, 2018
G-quadruplex (G4) nucleic acid structures have been reported to be involved in several human pathologies, including cancer, neurodegenerative disorders and infectious diseases; however, G4 targeting compounds still need implementation in terms of drug ...
Butovskaya, Elena, Doria, Filippo, Freccero, Mauro, Lena, Alberto, Nadai, Matteo, Pirota, Valentina, Richter, Sara N, Tassinari, Martina   +7 more
core   +2 more sources

G-Quadruplexes as Sensing Probes [PDF]

Molecules, 2013
Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. G-quadruplexes act as ligands for metal ions and aptamers for various molecules.
Ruttkay-Nedecký, Branislav, Kudr, Jiří, Nejdl, Lukáš, Mašková, Darina, Kizek, René, Adam, Vojtěch   +5 more
openaire   +4 more sources

Progress in ion detection and clinical diagnosis based on G-quadruplex combined with fluorescence properties

Advanced Sensor and Energy Materials
G-quadruplex is a high-level structure composed of folded DNA or RNA rich in tandem repeats of guanine (G). In recent years, G-quadruplex is widely used in various fields due to its unique structural properties.
Ping Lu, Gerile Aodeng, Jun Ai
doaj   +1 more source