Results 51 to 60 of about 13,196,617 (310)
Kinetics and thermodynamics of G-quadruplexes [PDF]
Nucleic Acids Symposium Series, 2005 The melting of tetramolecular DNA or RNA quadruplexes is kinetically irreversible. However, rather than being a hindrance, this kinetic inertia allows us to study association and dissociation processes independently. General rules have been extended to longer DNA motifs or sequences containing modified bases such as 8-oxo or 7-deaza guanine.
Julien, Gros +9 more
openaire +2 more sources
Novel splicing in IGFN1 intron 15 and role of stable G-quadruplex in the regulation of splicing in renal cell carcinoma. [PDF]
PLoS ONE, 2018 The IGFN1 (Immunoglobulin-Like And Fibronectin Type III Domain Containing 1) gene has a role in skeletal muscle function and is also involved in metastatic breast cancer, and the isoforms with three N-terminal globular domains are sufficient for its ...
Shiv Prakash Verma, Parimal Das
doaj +1 more source
Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy
Molecules, 2019 A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-rich sequences, and has profound implications for various pharmacological and biological events, including cancers.
Sefan Asamitsu +4 more
semanticscholar +1 more source
Topologies of G-quadruplex: Biological functions and regulation by ligands.
Biochemical and Biophysical Research Communications - BBRC, 2020 G-Quadruplex (G4) is one of the higher-order structures occurring in guanine-rich sequences of nucleic acids, and plays critical roles in biological processes. The G4-forming sequences can generate three kinds of topologies, i.e., parallel, anti-parallel,
Yue Ma, Keisuke Iida, K. Nagasawa
semanticscholar +1 more source
PLoS ONE, 2012 Studies on ligand interaction with quadruplex DNA, and their role in stabilizing the complex at concentration prevailing under physiological condition, has attained high interest.
Gajjela Raju +5 more
doaj +1 more source
RNA G-quadruplex structures exist and function in vivo in plants
Genome Biology, 2020 Background Guanine-rich sequences are able to form complex RNA structures termed RNA G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed to exist in vivo and are suggested to be associated with important biological ...
Xiaofei Yang +10 more
doaj +1 more source
G-Quadruplexes as Sensing Probes [PDF]
Molecules, 2013 Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. G-quadruplexes act as ligands for metal ions and aptamers for various molecules.
Ruttkay-Nedecký, Branislav +5 more
openaire +4 more sources
Advanced Sensor and Energy MaterialsG-quadruplex is a high-level structure composed of folded DNA or RNA rich in tandem repeats of guanine (G). In recent years, G-quadruplex is widely used in various fields due to its unique structural properties.
Ping Lu, Gerile Aodeng, Jun Ai
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The Presence and Localization of G-Quadruplex Forming Sequences in the Domain of Bacteria
Molecules, 2019 The role of local DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, the significance of G-quadruplexes was demonstrated in the last decade, and their presence and functional
Martin Bartas +9 more
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source