Results 51 to 60 of about 13,927,214 (311)
Discovery of G-quadruplex-forming sequences in SARS-CoV-2
Briefings Bioinform., 2020 The outbreak caused by the novel coronavirus SARS-CoV-2 has been declared a global health emergency. G-quadruplex structures in genomes have long been considered essential for regulating a number of biological processes in a plethora of organisms.
Danyang Ji +5 more
semanticscholar +1 more source
Stability of telomeric G-quadruplexes [PDF]
Nucleic Acids Research, 2010 In most eukaryotes, telomeric DNA consists of repeats of a short motif that includes consecutive guanines and may hence fold into G-quadruplexes. Budding yeasts have telomeres composed of longer repeats and show variation in the degree of repeat homogeneity. Although telomeric sequences from several organisms have been shown to fold into G-quadruplexes
Tran, Phong Lan Thao +2 more
openaire +3 more sources
Kinetics and thermodynamics of G-quadruplexes [PDF]
Nucleic Acids Symposium Series, 2005 The melting of tetramolecular DNA or RNA quadruplexes is kinetically irreversible. However, rather than being a hindrance, this kinetic inertia allows us to study association and dissociation processes independently. General rules have been extended to longer DNA motifs or sequences containing modified bases such as 8-oxo or 7-deaza guanine.
Julien, Gros +9 more
openaire +2 more sources
PLoS ONE, 2012 Studies on ligand interaction with quadruplex DNA, and their role in stabilizing the complex at concentration prevailing under physiological condition, has attained high interest.
Gajjela Raju +5 more
doaj +1 more source
Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy
Molecules, 2019 A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-rich sequences, and has profound implications for various pharmacological and biological events, including cancers.
Sefan Asamitsu +4 more
semanticscholar +1 more source
Chemical profiling of DNA G-quadruplex-interacting proteins in live cells
Nature Chemistry, 2021 DNA–protein interactions regulate critical biological processes. Identifying proteins that bind to specific, functional genomic loci is essential to understand the underlying regulatory mechanisms on a molecular level.
Xiaoyun Zhang +4 more
semanticscholar +1 more source
Advanced Sensor and Energy MaterialsG-quadruplex is a high-level structure composed of folded DNA or RNA rich in tandem repeats of guanine (G). In recent years, G-quadruplex is widely used in various fields due to its unique structural properties.
Ping Lu, Gerile Aodeng, Jun Ai
doaj +1 more source
RNA G-quadruplex structures exist and function in vivo in plants
Genome Biology, 2020 Background Guanine-rich sequences are able to form complex RNA structures termed RNA G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed to exist in vivo and are suggested to be associated with important biological ...
Xiaofei Yang +10 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
The Presence and Localization of G-Quadruplex Forming Sequences in the Domain of Bacteria
Molecules, 2019 The role of local DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, the significance of G-quadruplexes was demonstrated in the last decade, and their presence and functional
Martin Bartas +9 more
doaj +1 more source