Results 71 to 80 of about 13,927,214 (311)
G4mismatch: Deep neural networks to predict G-quadruplex propensity based on G4-seq data.
PLoS Computational Biology, 2023 G-quadruplexes are non-B-DNA structures that form in the genome facilitated by Hoogsteen bonds between guanines in single or multiple strands of DNA.
Mira Barshai +3 more
doaj +1 more source
Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36
Nature, 2018 Guanine-rich nucleic acid sequences challenge the replication, transcription, and translation machinery by spontaneously folding into G-quadruplexes, the unfolding of which requires forces greater than most polymerases can exert1,2.
Michael C. Chen +6 more
semanticscholar +1 more source
G-quadruplex organic frameworks [PDF]
Nature Chemistry, 2016 Two-dimensional covalent organic frameworks often π stack into crystalline solids that allow precise spatial positioning of molecular building blocks. Inspired by the hydrogen-bonded G-quadruplexes found frequently in guanine-rich DNA, here we show that this structural motif can be exploited to guide the self-assembly of naphthalene diimide and ...
Yi-Lin Wu +11 more
openaire +3 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Hemin/G-quadruplex DNAzyme for Designing of Electrochemical Sensors
International Journal of Electrochemical Science, 2015 Guanine-rich nucleic acid sequence can fold into guanine quadruplex (G-quadruplex) that is found to complex tightly with hemin to form the hemin/G-quadruplex.
Guo-Cheng Han +2 more
doaj +1 more source
Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity. [PDF]
PLoS ONE, 2013 G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome.
Rosalba Perrone +7 more
doaj +1 more source
A guide to computational methods for G-quadruplex prediction
Nucleic Acids Research, 2019 Guanine-rich nucleic acids can fold into the non-B DNA or RNA structures called G-quadruplexes (G4). Recent methodological developments have allowed the characterization of specific G-quadruplex structures in vitro as well as in vivo, and at a much ...
E. P. Puig Lombardi, A. Londoño-Vallejo
semanticscholar +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Molecules, 2012 The G-quadruplex, a four-stranded DNA structure with stacked guanine tetrads (G-quartets), has recently been attracting attention because of its critical roles<em> in vitro</em> and<em> in vivo</em>.
Naoki Sugimoto +3 more
doaj +1 more source