Results 61 to 70 of about 13,196,617 (310)
Metal Cations in G-Quadruplex Folding and Stability
Frontiers in Chemistry, 2016 This review is focused on the structural and physicochemical aspects of metal cation coordination to G-Quadruplexes (GQ) and their effects on GQ stability and conformation. G-quadruplex structures are non-canonical secondary structures formed by both DNA
Debmalya Bhattacharyya +2 more
semanticscholar +1 more source
Isothermal folding of G-quadruplexes [PDF]
Methods, 2012 Thermodynamic studies of G-quadruplex stability are an essential complement to structures obtained by NMR or X-ray crystallography. An understanding of the energetics of quadruplex folding provides a necessary foundation for the physical interpretation of quadruplex formation and reactivity.
Gray, Robert D, Chaires, Jonathan B
openaire +2 more sources
A new cationic porphyrin derivative (TMPipEOPP) with large side arm substituents: a highly selective G-quadruplex optical probe. [PDF]
PLoS ONE, 2012 The discovery of uncommon DNA structures and speculation about their potential functions in genes has brought attention to specific DNA structure recognition.
Li-Na Zhu +4 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
A Photoresponsive Supramolecular G-Quadruplex [PDF]
Organic Letters, 2013 Photoirradiation of a hexadecameric supramolecular G-quadruplex leads to a diastereoselective [2 + 2] cyclodimerization of half of its constituent subunits, which in turn shifts the equilibrium toward the formation of a precise heteromeric octamer.
José M, Rivera, Diana, Silva-Brenes
openaire +2 more sources
G4mismatch: Deep neural networks to predict G-quadruplex propensity based on G4-seq data.
PLoS Computational Biology, 2023 G-quadruplexes are non-B-DNA structures that form in the genome facilitated by Hoogsteen bonds between guanines in single or multiple strands of DNA.
Mira Barshai +3 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Chemical profiling of DNA G-quadruplex-interacting proteins in live cells
Nature Chemistry, 2021 DNA–protein interactions regulate critical biological processes. Identifying proteins that bind to specific, functional genomic loci is essential to understand the underlying regulatory mechanisms on a molecular level.
Xiaoyun Zhang +4 more
semanticscholar +1 more source
G-quadruplex organic frameworks [PDF]
Nature Chemistry, 2016 Two-dimensional covalent organic frameworks often π stack into crystalline solids that allow precise spatial positioning of molecular building blocks. Inspired by the hydrogen-bonded G-quadruplexes found frequently in guanine-rich DNA, here we show that this structural motif can be exploited to guide the self-assembly of naphthalene diimide and ...
Yi-Lin Wu +11 more
openaire +3 more sources
Formation of G-quadruplex and Its Utilizing for an Automated Spectrometric Detection of Cisplatin
International Journal of Electrochemical Science, 2015 Here, we studied the formation of G-quadruplex using spectrophotometric methods (peroxidase activity of G-quadruplex) and verifications of obtained results by voltammetry (cytosine-adenine (CA) or guanine (G) peaks height).
Branislav Ruttkay-Nedecky +9 more
doaj +1 more source