Results 91 to 100 of about 11,711,774 (302)
G-quadruplexes: Kinetic stability and effects on the c-KIT promoter
, 2013 In addition to the famous Watson & Crick model for B-form duplex DNA, guanine-rich DNA sequences can self-assemble under certain conditions to form a four-stranded structure known as a G-quadruplex. G-quadruplexes are composed of stacks of Gquartets,
Raouf, Tara
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Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells [PDF]
, 2020 Targeting G-quadruplex structures is currently viewed as a promising anticancer strategy. Searching for potent and selective G-quadruplex binders, here we describe a small series of new monohydrazone derivatives designed as analogues of a lead which was ...
Locatelli A. +9 more
core +1 more source
Advanced Functional Materials, EarlyView.The design of intrinsically robust stretchable semiconducting polymers was achieved through OTBS‐mediated post‐functionalization of PDPP2T side chains with UPy units, generating dual hydrogen‐bonding motifs comprising weaker urethane linkages and strong quadruple UPy interactions along the long alkyl side chain, which is crucial for achieving desirable
Dinda Bazliah +7 more
wiley +1 more source
G-Quadruplex DNA and RNA [PDF]
, 2019 G-quadruplexes (G4s) have become one of the most exciting nucleic acid secondary structures. A noncanonical, four-stranded structure formed in guanine-rich DNA and RNA sequences, G-quadruplexes can readily form under physiologically relevant conditions and are globularly folded structures.
openaire +2 more sources
Modulation of histone modifications and G-quadruplex structures by G-quadruplex-binding proteins
Biochemical and Biophysical Research Communications, 2020 The functions of local conformations of non-B form DNA and RNA, such as the G-quadruplex, are thought to be regulated by their specific binding proteins. They regulate the formation of G-quadruplexes in cells and affect the biological functions of G-quadruplexes.
Takanori, Oyoshi, Tatsuki, Masuzawa
openaire +3 more sources
Memristive‐Gated RC‐Delay Synaptic Transistors for Time‐Encoded Analog in‐Memory Computing
Advanced Functional Materials, EarlyView.A Memristive‐Gated Transistor for Time‐Encoded Analog In‐Memory Computing — By exploiting the RC delay of a self‐rectifying interface‐type memristor, nonlinear I–V distortion is structurally bypassed, enabling 3‐bit nonvolatile memory, spike‐timing‐based analog encoding, and hardware‐calibrated reservoir‐computing validation within a unified device ...
Yun‐Seo Shin +7 more
wiley +1 more source
Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound
, 2016 Inhibition of Human Telomerase by a G-Quadruplex-Interactive ...
Daekyu Sun (11744) +8 more
core +1 more source
Advanced Functional Materials, EarlyView.A field‐driven transition from chiral stripes to an achiral fan state is observed in a tetragonal magnet and linked to a temperature‐dependent rotation of the effective Dzyaloshinskii–Moriya interaction axis. This interplay generates pronounced in‐plane anisotropy and provides a new route for controlling chiral spin textures in noncentrosymmetric ...
Victor Ukleev +19 more
wiley +1 more source
Xanthene and Xanthone Derivatives as G-Quadruplex Stabilizing Ligands
Molecules, 2013 Following previous studies on anthraquinone and acridine-based G-quadruplex ligands, here we present a study of similar aromatic cores, with the specific aim of increasing G-quadruplex binding and selectivity with respect to duplex DNA.
Alessandro Altieri +7 more
doaj +1 more source
Molecules, 2020 A G-rich sequence containing three loops to connect four G-tracts with each ≥2 guanines can possibly form G-quadruplex structures. Given that all G-quadruplex structures comprise the stacking of G-quartets, the loop sequence plays a major role on their ...
Jie Li +5 more
doaj +1 more source