Results 101 to 110 of about 32,953 (312)

Targeting G-Quadruplex DNA with Small Molecules

CHIMIA, 2009
Despite a recent explosion of interest in G-quadruplex DNA, most fundamental questions regarding the possible presence and function of these intriguing structures in vivo remain unanswered.
Nathan W. Luedtke
doaj   +1 more source

Design of surface-active artificial enzyme particles to stabilize Pickering emulsions for high-performance biphasic biocatalysis [PDF]

, 2015
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Surface-active artificial enzymes (SAEs) are designed and constructed by a general and novel strategy.
Baciocchi, Binks, Bonomi, Chen, Chen, Crossley, Dewey, Diez-Castellnou, Gao, Jiang, Kapil, Kosif, Köhler, Li, Li, Lin, Liu, Liu, Mondloch, Nanda, Natalio, Neverov, Pengo, Pera-Titus, Silverman, Smith, Song, Sun, Tonga, Vernekar, Wang, Wang, Wang, Wiese, Wu, Yang, Zapata, Zaramella, Zhang, Zhou   +39 more
core   +1 more source

Clinical, histological, and serological predictors of renal function loss in lupus nephritis.

Arthritis Care &Research, Accepted Article.
Objective Kidney survival is the ultimate goal in lupus nephritis (LN) management, but long‐term predictors remain inadequately studied, requiring long‐term follow‐up. This study aimed to identify baseline and early longitudinal predictors of kidney survival in the Accelerating Medicines Partnership LN longitudinal cohort.
Shangzhu Zhang, Laurence Magder, Daniel Goldman, Judith A. James, Joel M Guthridge, Carla Guthridge, Peter Izmirly, Jill P Buyon, H.Michael Belmont, Richard A. Furie, Noa Schwartz, Chaim Putterman, Jennifer L. Barnas, Jennifer H. Anolik, Sarah French, Maria Dall'era, Avi Z. Rosenberg, Jeffrey Hodgin, Dawit S. Demeke, the Accelerating Medicines Partnership RA/SLE Network, Michelle Petri, Andrea Fava   +21 more
wiley   +1 more source

Evidence for a quadruplex structure in the polymorphic hs1.2 enhancer of the immunoglobulin heavy chain 3’ regulatory regions and its conservation in mammals [PDF]

, 2016
Regulatory regions in the genome can act through a variety of mechanisms that range from the occurrence of histone modifications to the presence of protein-binding loci for self-annealing sequences.
Cacchione, Stefano, Cicconi, Alessandro, D'Addabbo, Pietro, Frezza, Domenico, Gargioli, Cesare, Giambra, Vincenzo, Kelly, Geoffrey, Micheli, Emanuela, Poma, Anna, Sette, Marco   +9 more
core   +2 more sources

Composition‐Tuned Enhancement of the Anomalous Nernst Effect in FeCo–Pt Thin Films on Rigid and Flexible Substrates

Advanced Engineering Materials, EarlyView.
Disordered (Fe50Co50)1−xPtx thin films exhibit a pronounced anomalous Nernst effect (ANE) with a strong composition dependence on both rigid and flexible substrates. The transverse thermoelectric response peaks near 22.5 at.% Pt, accompanied by enhanced αxy/σxy scaling, thermal transport, and ANE sensitivity.
Mojtaba Mohammadi, Hiroyuki Awano, Kenji Tanabe   +2 more
wiley   +1 more source

Characterization of G-Quadruplex Motifs in espB, espK, and cyp51 Genes of Mycobacterium tuberculosis as Potential Drug Targets

Molecular Therapy: Nucleic Acids, 2019
G-quadruplex structure forming motifs are among the most studied evolutionarily conserved drug targets that are present throughout the genome of different organisms and susceptible to influencing various biological processes.
Subodh Kumar Mishra, Uma Shankar, Neha Jain, Kriti Sikri, Jaya Sivaswami Tyagi, Tarun Kumar Sharma, Jean-Louis Mergny, Amit Kumar   +7 more
doaj   +1 more source

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands. [PDF]

, 2001
G-Quadruplex DNAs are folded, non-Watson-Crick structures that can form within guanine-rich DNA sequences such as telomeric repeats. Previous studies have identified a series of trisubstituted acridine derivatives that are potent and selective ligands ...
Bohr, VA, Brosh, RM, Harrison, RJ, Hickson, ID, Li, JL, Neidle, S, Reszka, AP   +6 more
core   +1 more source

Parameter Variation in Planetary Ball Milling of Titanium Aluminide Powder in XHV‐Adequate Atmosphere

Advanced Engineering Materials, EarlyView.
This study investigates the effects of milling parameters, including rotational speed, milling duration, and ball‐to‐powder ratio, on TiAl particle size and morphology in an XHV‐equivalent atmosphere. The creation of oxide‐free surfaces enhances the mechanical properties of green bodies.
Jytte Möckelmann, Armin Piwek, Julius Peddinghaus, Kai Brunotte, Bernd-Arno Behrens   +4 more
wiley   +1 more source

Development of a series of bis-triazoles as G-quadruplex ligands [PDF]

, 2017
Maintenance of telomeres – specialized complexes that protect the ends of chromosomes – is provided by the enzyme complex telomerase, which is a key factor that is activated in more than 80% of cancer cells, but absent in most normal cells.
Abu-Orabi, Ambrus, Bai, Bauer, Campbell, Cian, Cini, Darby, De Cian, Denizot, Devarajan-Ketha, Dixon, Eldridge, Elwood, Fasman, Friesner, Garner, Gavathiotis, Gunaratnam, Johnson, Marminon, Mergny, Mergny, Monchaud, Moore, Moorhouse, Mosmann, Olovinkov, Olovnikov, Parkinson, Parkinson, Patel, Phan, Pruzan, Renciuk, Shin-ya, Wai, Wang, Woody, Xu   +39 more
core   +1 more source

Composites of Shellac and Silver Nanowires as Flexible, Biobased, and Corrosion‐Resistant Transparent Conductive Electrodes

Advanced Functional Materials, EarlyView.
Shellac, a centuries‐old natural resin, is reimagined as a green material for flexible electronics. When combined with silver nanowires, shellac films deliver transparency, conductivity, and stability against humidity. These results position shellac as a sustainable alternative to synthetic polymers for transparent conductors in next‐generation ...
Rahaf Nafez Hussein, Tiago Carneiro Gomes, Eliza Ng, Simon Rondeau‐Gagné, Tricia Breen Carmichael   +4 more
wiley   +1 more source