Results 11 to 20 of about 13,927,214 (311)
G-Quadruplexes and Their Ligands: Biophysical Methods to Unravel G-Quadruplex/Ligand Interactions [PDF]
Pharmaceuticals, 2021 Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of approaches that assess the binding mode and nature of the interactions between G4 forming sequences and their putative ligands.
Tiago Santos +3 more
semanticscholar +5 more sources
Microbiology Spectrum, 2022 Human enteroviruses cause many diseases; however, there is no specific therapeutic drug. G-quadruplex is an atypical secondary structure formed in the guanine rich region of DNA or RNA, which can exist in the viral genome.
Lu Lv, Leiliang Zhang
doaj +3 more sources
G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders [PDF]
Nucleic Acids Research, 2020 Genomic DNA and cellular RNAs can form a variety of non-B secondary structures, including G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held together by Hoogsteen hydrogen bonds and can form at key regulatory sites of ...
G. Miglietta, Marco Russo, G. Capranico
semanticscholar +4 more sources
G-Quadruplexes in the Archaea Domain [PDF]
Biomolecules, 2020 The importance of unusual DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, G-quadruplexes (G4s) have gained in popularity during the last decade, and their presence and functional relevance at the DNA and RNA level has been demonstrated in a number of viral, bacterial ...
Václav Brázda +13 more
openaire +6 more sources
G-quadruplexes and helicases [PDF]
Nucleic Acids Research, 2016 Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as 'knots' within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures.
Mendoza, Oscar +4 more
openaire +3 more sources
PLoS ONE, 2022 GW-2974 is a potent tyrosine kinase receptor inhibitor while SCH-442416 is a potent adenosine receptors' antagonist with high selectivity towards human adenosine A2A receptor over other adenosine receptors. The two compounds were reported to possess anti-
Alaa A Salem +2 more
doaj +3 more sources
Heliyon, 2023 G-quadruplex, a structurally unique structure in nucleic acids present all throughout the human genome, has sparked great attention in therapeutic investigations. Targeting G-quadruplex structure is a new strategy for the drug development. Flavonoids are
Sagar Bag +2 more
doaj +1 more source
RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection
Nature Communications, 2022 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have devastating consequences worldwide. Recently, great efforts have been made to identify SARS-CoV-2 host factors, but the regulatory mechanisms of these host molecules,
Geng Liu +11 more
semanticscholar +1 more source
Binding-Induced Diversity of a Human Telomeric G-Quadruplex Stability Phase Space
Pharmaceuticals, 2022 The structural polymorphism of G-quadruplex nucleic acids is an important factor in their recognition by proteins and small-molecule ligands. However, it is not clear why the binding of several ligands alters G-quadruplex topology.
Domen Oblak +3 more
doaj +1 more source
RNA G-quadruplex structure contributes to cold adaptation in plants
bioRxiv, 2022 Nucleotide composition is suggested to infer gene functionality and ecological adaptation of species to distinct environments. However, the underlying biological function of nucleotide composition dictating environmental adaptations is largely unknown ...
Xiaofei Yang +9 more
semanticscholar +1 more source