Results 11 to 20 of about 32,953 (312)
PLoS ONE, 2022 GW-2974 is a potent tyrosine kinase receptor inhibitor while SCH-442416 is a potent adenosine receptors' antagonist with high selectivity towards human adenosine A2A receptor over other adenosine receptors. The two compounds were reported to possess anti-
Alaa A Salem +2 more
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Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids
Pharmaceuticals, 2021 The role of G-quadruplexes in human cancers is increasingly well-defined. Accordingly, G-quadruplexes can be suitable drug targets and many small molecules have been identified to date as G-quadruplex binders, some using computer-based design methods and
Stephen Neidle
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Binding-Induced Diversity of a Human Telomeric G-Quadruplex Stability Phase Space
Pharmaceuticals, 2022 The structural polymorphism of G-quadruplex nucleic acids is an important factor in their recognition by proteins and small-molecule ligands. However, it is not clear why the binding of several ligands alters G-quadruplex topology.
Domen Oblak +3 more
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G-quadruplexes and helicases [PDF]
Nucleic Acids Research, 2016 Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as 'knots' within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures.
Mendoza, Oscar +4 more
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Heliyon, 2023 G-quadruplex, a structurally unique structure in nucleic acids present all throughout the human genome, has sparked great attention in therapeutic investigations. Targeting G-quadruplex structure is a new strategy for the drug development. Flavonoids are
Sagar Bag +2 more
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G‐Quadruplex Nucleic Acids [PDF]
Journal of Nucleic Acids, 2010 Peer ...
ERITJA R. +4 more
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Polyelectrolyte effects in G-quadruplexes [PDF]
Biophysical Chemistry, 2013 The role of counterion condensation as a dominant force governing the stability of DNA duplexes and triplexes is well established. In contrast, the effect of counterion condensation on the stability of G-quadrupex conformations is poorly understood. Unlike other ordered nucleic acid structures, G-quadruplexes exhibit a specific binding of counterions ...
Kim, Byul +2 more
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Duplex DNA from Sites of Helicase-Polymerase Uncoupling Links Non-B DNA Structure Formation to Replicative Stress [PDF]
, 2020 BACKGROUND: Replication impediments can produce helicase-polymerase uncoupling allowing lagging strand synthesis to continue for as much as 6 kb from the site of the impediment.
Abdelhamid, Mahmoud A S +9 more
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G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2011 G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. DNA G-quadruplexes have recently emerged as attractive cancer therapeutic targets. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures.
Raveendra I, Mathad, Danzhou, Yang
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Aminoglycosylation can enhance the G-quadruplex binding activity of epigallocatechin. [PDF]
PLoS ONE, 2013 With the aim of enhancing G-quadruplex binding activity, two new glucosaminosides (16, 18) of penta-methylated epigallocatechin were synthesized by chemical glycosylation.
Li-Ping Bai +5 more
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