Results 11 to 20 of about 13,196,617 (310)
G-Quadruplexes and Their Ligands: Biophysical Methods to Unravel G-Quadruplex/Ligand Interactions [PDF]
Pharmaceuticals, 2021 Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of approaches that assess the binding mode and nature of the interactions between G4 forming sequences and their putative ligands.
Tiago Santos +3 more
semanticscholar +5 more sources
G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders [PDF]
Nucleic Acids Research, 2020 Genomic DNA and cellular RNAs can form a variety of non-B secondary structures, including G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held together by Hoogsteen hydrogen bonds and can form at key regulatory sites of ...
G. Miglietta, Marco Russo, G. Capranico
semanticscholar +4 more sources
Molecules, 2019 G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome. G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or ...
Zhi-Yin Sun +4 more
doaj +2 more sources
G-Quadruplexes in the Archaea Domain [PDF]
Biomolecules, 2020 The importance of unusual DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, G-quadruplexes (G4s) have gained in popularity during the last decade, and their presence and functional relevance at the DNA and RNA level has been demonstrated in a number of viral, bacterial ...
Václav Brázda +13 more
openaire +6 more sources
Accounts of Chemical Research, 2022 CONSPECTUS: DNA G-quadruplex secondary structures formed in guanine-rich human telomeres and oncogene promoters are functionally important and have emerged as a promising new class of cancer-specific drug targets. These globular intramolecular structures
Luying Chen +3 more
semanticscholar +1 more source
DNA G-quadruplex structures: more than simple roadblocks to transcription?
Nucleic Acids Research, 2021 It has been >20 years since the formation of G-quadruplex (G4) secondary structures in gene promoters was first linked to the regulation of gene expression.
Jenna Robinson +4 more
semanticscholar +1 more source
Stress promotes RNA G-quadruplex folding in human cells
bioRxiv, 2022 Guanine (G)-rich nucleic acids can fold into G-quadruplex (G4) structures under permissive conditions. Although many RNAs contain sequences that fold into RNA G4s (rG4s) in vitro, their folding and functions in vivo are not well understood.
Prakash Kharel +6 more
semanticscholar +1 more source
G-quadruplexes and helicases [PDF]
Nucleic Acids Research, 2016 Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as 'knots' within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures.
Mendoza, Oscar +4 more
openaire +3 more sources
RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection
Nature Communications, 2022 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have devastating consequences worldwide. Recently, great efforts have been made to identify SARS-CoV-2 host factors, but the regulatory mechanisms of these host molecules,
Geng Liu +11 more
semanticscholar +1 more source
G‐Quadruplex Nucleic Acids [PDF]
Journal of Nucleic Acids, 2010 Peer ...
ERITJA R. +4 more
openaire +5 more sources