Results 11 to 20 of about 7,473,748 (355)

A bouquet of DNA structures: Emerging diversity

Biochemistry and Biophysics Reports, 2016
Structural polymorphism of DNA has constantly been evolving from the time of illustration of the double helical model of DNA by Watson and Crick. A variety of non-canonical DNA structures have constantly been documented across the globe.
Mahima Kaushik, Shikha Kaushik, Kapil Roy, Anju Singh, Swati Mahendru, Mohan Kumar, Swati Chaudhary, Saami Ahmed, Shrikant Kukreti   +8 more
doaj   +1 more source

Ultrasensitive detection of nucleic acids using deformed graphene channel field effect biosensors

Nature Communications, 2020
Field-effect transistor (FET)-based biosensors allow label-free detection of biomolecules by measuring their intrinsic charges. The detection limit of these sensors is determined by the Debye screening of the charges from counter ions in solutions. Here,
M. T. Hwang, M. Heiranian, Yerim Kim, Seungyong You, Juyoung Leem, Amir Taqieddin, V. Faramarzi, Y. Jing, Insu Park, A. M. van der Zande, Sungwoo Nam, N. Aluru, R. Bashir   +12 more
semanticscholar   +1 more source

Deciphering the tRNA-derived small RNAs: origin, development, and future

Cell Death and Disease, 2021
Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the roles of tsRNAs in the development of human diseases.
Bowen Liu, Jinling Cao, Xiangyun Wang, Chunlei Guo, Yunxia Liu, Tianjiao Wang   +5 more
doaj   +1 more source

Self-association of Coralyne: An ordered thermal destacking

Results in Chemistry, 2020
Understanding DNA-ligand interactions is a prerequisite, for designing sequence/structure specific ligands. Generally, stabilization/destabilization of DNA structures as a function of ligand is studied using UV-thermal melting, and the data is usually ...
Shikha Kaushik, Mahima Kaushik, Ritu Barthwal, Shrikant Kukreti   +3 more
doaj   +1 more source

Protein-induced changes in DNA structure and dynamics observed with noncovalent site-directed spin-labeling and PELDOR [PDF]

, 2012
Site-directed spin labeling and pulsed electron–electron double resonance (PELDOR or DEER) have previously been applied successfully to study the structure and dynamics of nucleic acids. Spin labeling nucleic acids at specific sites requires the covalent
Reginsson, Gunnar Widtfeldt, Rouillon, Christophe, Schiemann, Olav, Sigurdsson, Snorri T, White, Malcolm F, Shelke, Sandip, White, Malcolm F; id_orcid   +6 more
core   +1 more source

Algorithms for Nucleic Acid Sequence Design [PDF]

, 2010
Motivated by a growing field of research focused on programming function into biomolecules, we seek to decrease the cost of high-quality rational nucleic acid sequence design while increasing its versatility and availability.
Zadeh, Joseph N.
core   +1 more source

Dual miRNases for Triple Incision of miRNA Target: Design Concept and Catalytic Performance

Molecules, 2020
Irreversible destruction of disease-associated regulatory RNA sequences offers exciting opportunities for safe and powerful therapeutic interventions against human pathophysiology.
Olga Patutina, Daria Chiglintseva, Elena Bichenkova, Svetlana Gaponova, Nadezhda Mironova, Valentin Vlassov, Marina Zenkova   +6 more
doaj   +1 more source

Synthesis of Polyanionic C5-Modified 2′-Deoxyuridine and 2′-Deoxycytidine-5′-Triphosphates and Their Properties as Substrates for DNA Polymerases

Molecules, 2021
Modified 2′-deoxyribonucleotide triphosphates (dNTPs) have widespread applications in both existing and emerging biomolecular technologies. For such applications it is an essential requirement that the modified dNTPs be substrates for DNA polymerases. To
Claire Dutson, Esther Allen, Mark J. Thompson, Joseph H. Hedley, Heather E. Murton, David M. Williams   +5 more
doaj   +1 more source

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

bioRxiv, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signalling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
M. Devos, G. Tanghe, B. Gilbert, Evelien Dierick, Maud Verheirstraeten, Josephine Nemegeer, Richard de Reuver, Sylvie Lefebvre, J. De Munck, J. Rehwinkel, P. Vandenabeele, W. Declercq, J. Maelfait   +12 more
semanticscholar   +1 more source

Characterization of Nucleic Acids and Nucleic Acid Binding Proteins Using NMR [PDF]

, 2017
Biological systems are governed by molecular interactions. At the core of all biological systems is the processing of nucleic acids, and preserving the fidelity of the genome is crucial to those systems.
Evich, Marina
core   +1 more source