Results 11 to 20 of about 465,053 (268)
Molecules, 2021 Modified 2′-deoxyribonucleotide triphosphates (dNTPs) have widespread applications in both existing and emerging biomolecular technologies. For such applications it is an essential requirement that the modified dNTPs be substrates for DNA polymerases. To
Claire Dutson +5 more
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Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model
Frontiers in Pharmacology, 2019 Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases ...
Olga A. Patutina +7 more
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The Nucleic Acid Database: A Resource for Nucleic Acid Science [PDF]
Acta Crystallographica Section D Biological Crystallography, 1998 The Nucleic Acid Database (NDB) distributes information about nucleic acid-containing structures. Here the information content of the database as well as the query capabilities are described. A summary of how the technology developed by this project has been used to develop other macromolecular databases is given.
H M, Berman, C, Zardecki, J, Westbrook
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Enhanced Hybridization Selectivity Using Structured GammaPNA Probes
Molecules, 2020 High affinity nucleic acid analogues such as gammaPNA (γPNA) are capable of invading stable secondary and tertiary structures in DNA and RNA targets but are susceptible to off-target binding to mismatch-containing sequences.
Taylor D. Canady +6 more
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Pharmaceutics, 2023 Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as powerful therapeutic compounds for targeting mRNAs and inducing their degradation. However, a major obstacle is that unmodified oligonucleotides are not readily taken up
Carme Fàbrega +5 more
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Molecules, 2021 RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are currently ...
Yaroslav Staroseletz +7 more
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Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos
Frontiers in Bioengineering and Biotechnology, 2020 The translational therapies to promote interaction between cell and signal come with stringent eligibility criteria. The chemically defined, hierarchically organized, and simpler yet blessed with robust intermolecular association, the peptides, are ...
Seema Gupta +4 more
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Molecular structure of nucleic acids [PDF]
Resonance, 1953 WE wish to suggest a structure for the salt of deoxyribose nucleic acid (D.N.A.). This structure has novel features which are of considerable biological interest. A structure for nucleic acid has already been proposed by Pauling and Corey1. They kindly made their manuscript available to us in advance of publication.
J D, WATSON, F H, CRICK
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Frontiers in Bioengineering and BiotechnologyIntroductionSmall membrane particles called extracellular vesicles (EVs) transport biologically active cargo between cells, providing intercellular communication.
Anastasiya Oshchepkova +15 more
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FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
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