Circulating Cell-Free Nucleic Acids as Epigenetic Biomarkers in Precision Medicine [PDF]
Frontiers in Genetics, 2020 The circulating cell-free nucleic acids (ccfNAs) are a mixture of single- or double-stranded nucleic acids, released into the blood plasma/serum by different tissues via apoptosis, necrosis, and secretions. Under healthy conditions, ccfNAs originate from
Beenish Rahat +4 more
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Circulating Cell-Free Nucleic Acids as Biomarkers for Diagnosis and Prognosis of Pancreatic Cancer [PDF]
Biomedicines, 2023 A lack of reliable early diagnostic tools represents a major challenge in the management of pancreatic cancer (PCa), as the disease is often only identified after it reaches an advanced stage.
Anelis Maria Marin +5 more
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Cell-Free Nucleic Acids As Noninvasive Biomarkers For Colorectal Cancer Detection [PDF]
Frontiers in Genetics, 2014 Cell-free nucleic acids (CFNA) have been reported by several authors in blood, stool and urine of patients with colorectal cancer (CRC). These genetic biomarkers can be an indication of neoplastic colorectal epithelial cells, so they can potentially be ...
Hicham eMansour
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Breath biopsy biomarkers: cell-free nucleic acids in exhaled breath condensate [PDF]
Frontiers in MedicineExhaled breath condensate (EBC) has emerged as a promising, organ-specific biofluid for non-invasive molecular diagnostics. While breath analysis has traditionally focused on volatile organic compounds (VOCs), recent advances have shifted attention ...
Ondrej Pös +16 more
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Circulating Cell-free Tumor Nucleic Acids in Gastric Cancer [PDF]
The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2018 Gastric cancer is still the leading cause of cancer deaths, especially in Asian countries. Recently, many studies have analyzed cell-free nucleic acids (cfNAs) circulating in the blood, for the early diagnosis of cancer and monitoring its progression ...
Hyun-Ji Lee, Sun Min Lee
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Increased levels of circulating cell‐free double‐stranded nucleic acids in the plasma of glioblastoma patients [PDF]
Journal of Extracellular BiologyCirculating cell‐free nucleic acids are considered a promising source of biomarkers for diseases and cancer. Liquid biopsy biomarkers for brain tumours represent a major, still unmet, clinical need.
Elisabeth Rackles +7 more
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Technical and Methodological Aspects of Cell-Free Nucleic Acids Analyzes. [PDF]
Int J Mol Sci, 2020 Analyzes of cell-free nucleic acids (cfNAs) have shown huge potential in many biomedical applications, gradually entering several fields of research and everyday clinical care. Many biological properties of cfNAs can be informative to gain deeper insights into the function of the organism, such as their different types (DNA, RNAs) and subtypes (gDNA ...
Pös Z +8 more
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Circulating Cell-Free Nucleic Acids: Main Characteristics and Clinical Application. [PDF]
Int J Mol Sci, 2020 Liquid biopsy recently became a very promising diagnostic method that has several advantages over conventional invasive methods. Liquid biopsy may serve as a source of several important biomarkers including cell-free nucleic acids (cf-NAs). Cf-DNA is widely used in prenatal testing in order to characterize fetal genetic disorders.
Szilágyi M +8 more
europepmc +5 more sources
Cell-Free Nucleic Acids: Physico-Chemical Properties, Analytical Considerations, and Clinical Applications [PDF]
Diagnostics, 2023 Human body fluids are rich sources of cell-free nuclear material, which exhibits unique characteristics [...]
Abel J. Bronkhorst, Stefan Holdenrieder
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Circulating cell-free nucleic acids of plasma in human aging, healthy aging and longevity: current state of knowledge [PDF]
Frontiers in Genetics, 2023 Circulating cell-free nucleic acids (ccfNAs) of plasma are a remarkable source of genetic, epigenetic and transcriptomic materials originating from different cells, tissues and organs of an individual.
Nicolas P. Tessier +4 more
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