Results 41 to 50 of about 588,360 (287)
Cell-free Fetal Nucleic Acid Identifier Markers in Maternal Circulation
Advanced Biomedical Research, 2017 From the discovery of cell-free fetal (cff)-DNA in 1997 so far, many studies have been performed on various aspects of cff-nucleic acid. It is undoubted that currently, invasive prenatal diagnosis progresses to the noninvasive test. However, there are many problems.
Mahboubeh Ramezanzadeh +2 more
openaire +3 more sources
Cell-free nucleic acid based non-invasive prenatal diagnosis of fetal aneuploidies [PDF]
Orvosi Hetilap, 2012 Prenatal detection of fetal aneuploidies is one of the main goals of the prenatal diagnostic approach. As a benefit of the development of advanced ultrasound equipment and advances in molecular biology in the last decade, there is a significant progress in screening methods for fetal aneuploidies, although invasive methods remain the gold standard for ...
Levente, Lázár +3 more
openaire +2 more sources
Locked nucleic acid oligomers as handles for single molecule manipulation. [PDF]
, 2014 Single-molecule manipulation (SMM) techniques use applied force, and measured elastic response, to reveal microscopic physical parameters of individual biomolecules and details of biomolecular interactions.
Berezney, John P, Saleh, Omar A
core +1 more source
Cancer type classification using plasma cell-free RNAs derived from human and microbes
eLife, 2022 The utility of cell-free nucleic acids in monitoring cancer has been recognized by both scientists and clinicians. In addition to human transcripts, a fraction of cell-free nucleic acids in human plasma were proven to be derived from microbes and ...
Shanwen Chen +20 more
doaj +1 more source
Efficient CRISPR-rAAV engineering of endogenous genes to study protein function by allele-specific RNAi. [PDF]
, 2015 Gene knockout strategies, RNAi and rescue experiments are all employed to study mammalian gene function. However, the disadvantages of these approaches include: loss of function adaptation, reduced viability and gene overexpression that rarely matches ...
Dowdy, Steven F +5 more
core +1 more source
Journal of Extracellular BiologyCirculating cell‐free nucleic acids are considered a promising source of biomarkers for diseases and cancer. Liquid biopsy biomarkers for brain tumours represent a major, still unmet, clinical need.
Elisabeth Rackles +7 more
doaj +1 more source
Pharmaceuticals, 2019 Antibiotic resistance is a growing public health concern. Because only a few novel classes of antibiotics have been developed in the last 40 years, such as the class of oxazolidinones, new antibacterial strategies are urgently needed (Coates, A.R. et al.,
Federico Perche +4 more
doaj +1 more source
The principles of isolation, purification and analysis of nucleic acids [PDF]
, 2003 Advanced Biotechnological research is largely depended on the genome analysis and recombinant DNA technology. Good quality nucleic acid is an essential prerequisite for consistent results in most of the down stream applications in the genome analysis ...
Paulton, M P, Thomas, P C
core
Developments in the tools and methodologies of synthetic biology. [PDF]
, 2014 Synthetic biology is principally concerned with the rational design and engineering of biologically based parts, devices, or systems. However, biological systems are generally complex and unpredictable, and are therefore, intrinsically difficult to ...
Freemont, P +3 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source