Results 51 to 60 of about 588,360 (287)

Diagnostic potential of cell-free fetal nucleic acids in predicting pregnancy complications: A systematic review and meta-analysis on trisomy, pre-eclampsia, and gestational diabetes

International Journal of Reproductive BioMedicine
Background: Recent studies reveal an association between increased cell-free fetal (cff) nucleic acid in maternal blood and pregnancy challenges like loss, pre-eclampsia, growth restriction, and preterm labor.
Jiut Ram Keshari, Pritam Prakash, Seema Rani Sinha, Prem Prakash, Kirti Rani, Tarique Aziz, Shaily Shilpa   +6 more
doaj   +1 more source

Nucleic acids and protein synthesis [PDF]

, 1964
The unprecedented growth of interest in protein synthesis among biochemists is both a result of, and has contributed to, our rapidly advancing knowledge of the chemistry and metabolism of the nucleic acids.
Nicol, Sheldon
core   +1 more source

The genome and transcriptome of Trichormus sp NMC-1: insights into adaptation to extreme environments on the Qinghai-Tibet Plateau [PDF]

, 2016
The Qinghai-Tibet Plateau (QTP) has the highest biodiversity for an extreme environment worldwide, and provides an ideal natural laboratory to study adaptive evolution.
A Stamatakis, A Zorina, AL Delcher, B Langmead, BA Methé, C Xie, DA Los, DJ Wright, EP Balskus, G Blanc, G Norsang, HÄ Suh, J Qi, J Qi, J Zhang, JF Hess, JI Carreto, JM Shick, JP Zehr, K Mavromatis, KS Siddiqui, L Li, L R, L Ran, M Borodovsky, M Dassanayake, M Li, M Suyama, N Myers, P Pereira, P Puigbò, P Rajaniemi, PH Sudmant, PM Shih, Q Qiu, Q Tang, R Cavicchioli, RC Edgar, RL Tatusov, S Richter, SP Singh, SP Singh, SP Singh, T De Bie, T Kaneko, T Kogej, T Shi, U Consortium, U Nübel, WM Fitch, Z Xu, Z Yang, Z Yang, ZA Cheviron   +53 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Opportunities and challenges of circulating biomarkers in neuroblastoma [PDF]

Open Biology, 2019
Molecular analysis of nucleic acid and protein biomarkers is becoming increasingly common in paediatric oncology for diagnosis, risk stratification and molecularly targeted therapeutics. However, many current and emerging biomarkers are based on analysis
Ricky M. Trigg, Jacqui A. Shaw, Suzanne D. Turner   +2 more
doaj   +1 more source

Antisense PNA accumulates in Escherichia coli and mediates a long post-antibiotic effect [PDF]

, 2007
Antisense agents that target growth-essential genes display surprisingly potent bactericidal properties. In particular, peptide nucleic acid (PNA) and phosphorodiamidate morpholino oligomers linked to cationic carrier peptides are effective in time kill ...
Behmanesh, Mehrdad, Dryselius, Rikard, Faridani, Omid R, Ganyu, Anita, Goh, Shan, Good, Liam, Klok, Erik Jan, Nikravesh, Abbas, Sadeghizadeh, Majid, Zain, Rula   +9 more
core   +2 more sources

Cell-free transcriptional regulation via nucleic-acid-based transcription factors [PDF]

, 2019
AbstractCells execute complex transcriptional programs by deploying distinct protein regulatory assemblies that interact with cis-regulatory elements throughout the genome. Using concepts from DNA nanotechnology, we synthetically recapitulated this feature in cell-free gene networks actuated by T7 RNA polymerase (RNAP).
Chou, Leo Y.T., Shih, William M.
openaire   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Cell-Free Circulating Nucleic Acids as Early Biomarkers for NAFLD and NAFLD-Associated Disorders

Frontiers in Physiology, 2018
Non-alcoholic fatty liver disease (NAFLD) is the worldwide most common cause of chronic liver pathology, which prevalence strongly correlates with the increasing incidence of diabetes, obesity and metabolic syndrome in the general population.
Andrey Turchinovich, Andrey Turchinovich, Ancha Baranova, Ancha Baranova, Ancha Baranova, Oksana Drapkina, Alexander Tonevitsky, Alexander Tonevitsky, Alexander Tonevitsky   +8 more
doaj   +1 more source

Denatured mammalian protein mixtures exhibit unusually high solubility in nucleic acid-free pure water. [PDF]

PLoS ONE, 2014
Preventing protein aggregation is a major goal of biotechnology. Since protein aggregates are mainly comprised of unfolded proteins, protecting against denaturation is likely to assist solubility in an aqueous medium.
Junichiro Futami, Haruna Fujiyama, Rie Kinoshita, Hidenori Nonomura, Tomoko Honjo, Hiroko Tada, Hirokazu Matsushita, Yoshito Abe, Kazuhiro Kakimi   +8 more
doaj   +1 more source