Results 11 to 20 of about 1,636,041 (314)

Cell-free DNA and outcome in sepsis. [PDF]

Critical Care, 2012
Severe sepsis can be a catastrophic condition that is often associated with poor outcomes. The early diagnosis and management of the condition are vital in order to improve the chances of survival. However, owing to the syndromal nature of its definition
Rhodes, A, Cecconi, M
core   +4 more sources

Immunoregulatory properties of cell free DNA. [PDF]

Cell Mol Life Sci
Abstract Cell free DNA (cfDNA) is detectable at low concentrations in the plasma of healthy subjects and at high concentrations in disorders characterized by a high rate of necrotic events, such as tumors and vasculitis, leading to the release of necrotic DNA into the surrounding tissue and the bloodstream.
Ferrera F, Altosole T, Tardito S, Astone G, Bernardi C, Parodi A, Marini C, Conteduca G, Cichero E, Salis A, Arpesella L, Camporesi L, Lagazio A, Rigo V, Pigozzo A, Damonte G, Fossa P, Fenoglio D, De Palma R, Inghirami G, Filaci G.   +20 more
europepmc   +3 more sources

cfGWAS reveal genetic basis of cell-free DNA end motifs. [PDF]

Nat Commun
Zhu H, Zhang Y, Li L, Zeng S, Zhang X, Lin Y, Ou R, Wang L, Li X, Wang Y, Zeng J, Lin Y, Xu C, Zeng G, Li L, Zhao R, Jia Y, Luo F, Yang M, Hu Y, Xiao H, Xu X, Wang J, Zhou A, Zhang H, Jin X.   +25 more
europepmc   +2 more sources

Cell-Free DNA in Rheumatoid Arthritis [PDF]

International Journal of Molecular Sciences, 2021
Endogenous DNA derived from the nuclei or mitochondria is released into the bloodstream following cell damage or death. Extracellular DNA, called cell-free DNA (cfDNA), is associated with various pathological conditions. Recently, multiple aspects of cfDNA have been assessed, including cfDNA levels, integrity, methylation, and mutations.
Hashimoto, Teppei, Yoshida, Kohsuke, Hashiramoto, Akira, Matsui, Kiyoshi   +3 more
openaire   +2 more sources

Cell-Free DNA in the Investigation of Miscarriage [PDF]

Journal of Clinical Medicine, 2020
Approximately one in four pregnancies result in pregnancy loss, and ~50% of these miscarriages are caused by chromosomal abnormalities. Genetic investigations are recommended after three consecutive miscarriages on products of conception (POC) tissue. Cell-free DNA (cfDNA) has been utilised for prenatal screening, but very little work has been carried ...
Emily Colley, Adam J. Devall, Helen Williams, Susan Hamilton, Paul Smith, Neil V. Morgan, Siobhan Quenby, Arri Coomarasamy, Stephanie Allen   +8 more
openaire   +3 more sources

Phenotypes from cell-free DNA [PDF]

Open Biology, 2020
Cell-free DNA (cfDNA) has the potential to enable non-invasive detection of disease states and progression. Beyond its sequence, cfDNA also represents the nucleosomal landscape of cell(s)-of-origin and captures the dynamics of the epigenome. In this review, we highlight the emergence of cfDNA epigenomic methods that assess disease beyond the scope of ...
Alexis Zukowski, Satyanarayan Rao, Srinivas Ramachandran   +2 more
openaire   +3 more sources

End-repair causes methylation underestimation in cell-free DNA sequencing libraries. [PDF]

J Liq Biopsy
Groth TE, Mishin AA, Rao V, Tibet R, Troll CJ.   +4 more
europepmc   +3 more sources

Cell-free (RNA) and cell-associated (DNA) HIV-1 and postnatal transmission through breastfeeding [PDF]

, 2012
<p>Introduction - Transmission through breastfeeding remains important for mother-to-child transmission (MTCT) in resource-limited settings. We quantify the relationship between cell-free (RNA) and cell-associated (DNA) shedding of HIV-1 virus in ...
Van de Perre, P, James Ndirangu, Ndirangu James, Ruth M. Bland, Van de Perre Philippe, Ruth M Bland, Thorne, C., Danaviah, S, Thorne Claire, Newell Marie-Louise, Newell, M.-L., Viljoen, J., Ndirangu, J., Newell, M-L, Thorne, C, Van de Perre, P., Danaviah Siva, Bland, R.M., Philippe Van de Perre, Viljoen, J, Marie-Louise Newell, Ndirangu, J, Claire Thorne, Bland, RM, Danaviah, S., Siva Danaviah, Viljoen Johannes, Bland Ruth M., Johannes Viljoen   +28 more
core   +1 more source

Noninvasive prenatal diagnosis of fetal RhD status using cell-free fetal DNA in maternal plasma with TaqMan® real-time PCR assay [PDF]

, 2007
Prenatal diagnosis is now part of established obstetric practice in many countries. However, conventional methods of prenatal diagnosis of obtaining fetal tissues for genetic analysis, including amniocentesis and chorionic villus sampling, are invasive
Rekhviashvili, Tea
core   +1 more source

Cell‐free DNA as a biomarker of aging [PDF]

Aging Cell, 2018
AbstractCell‐free DNA (cfDNA) is present in the circulating plasma and other body fluids and is known to originate mainly from apoptotic cells. Here, we provide the first in vivo evidence of global and local chromatin changes in human aging by analyzing cfDNA from the blood of individuals of different age groups.
Teo YV, Capri M, Morsiani C, Pizza G, Faria AMC, Franceschi C, Neretti N.   +6 more
openaire   +3 more sources