Results 21 to 30 of about 1,636,041 (314)
Cell-free DNA in the circulation as a non-invasive biomarker for breast cancer [PDF]
, 2013 Breast cancer remains the most common cancer among women worldwide. Although standard screening methods such as clinical breast examination (CBE) and Full-Field Digital Mammography (FFDM) are non-invasive itself, their sensitivity and specificity is ...
Kohler, Corina
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Biochemical and clinical diagnostic aspects of circulating nucleic acids [PDF]
, 2005 We investigated the size distribution of fetal DNA using a combination of agorose gel electrophoresis, Southern blot and real time PCR assay. Our results showed plasma DNA presents apoptotic characteristics and the cell free fetal DNA is generally ...
Li, Ying
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Cell-free DNA as a biomarker in cancer
Extracellular Vesicles and Circulating Nucleic Acids, 2022 Translational research of liquid biopsy is just at the edge of routine clinical application: an emerging validity of circulating tumor DNA (ctDNA) tests suggests its use for earlier cancer detection and better monitoring of minimal residual disease (MRD) and resistance development, thus offering earlier guidance for therapy choices with the intent to ...
Robert H. Eibl, Markus Schneemann
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Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]
, 2015 Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Gerdes, K. +27 more
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Circulating Cell-Free DNA in Cancer
, 2014 This papers deals with the preanalytical and analytical phase of cell-free DNA analysis, highlighting some criticism on sample collection and extraction. We describe a method to accurately quantify total cfDNA in plasma and our particular approach to the measurement of tumor deriving cfDNA.
PINZANI, PAMELA +3 more
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Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells [PDF]
, 2009 © 2009 by The American Society for Cell Biology.The telomere end-protection complex prevents the ends of linear eukaryotic chromosomes from degradation or inappropriate DNA repair. The homodimeric double-stranded DNA-binding protein, Trf1, is a component
Modino, S +17 more
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Molecular basis for SMC rod formation and its dissolution upon DNA binding. [PDF]
, 2015 SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a constitutive "hinge" dimerization domain with an ATP-regulated "head ...
Soh, Young-Min +69 more
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Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase [PDF]
, 2014 Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic ...
Jaiswal, H. +9 more
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, 2014 Early prediction of prognosis is helpful in cardiac arrest patients. Plasma cell-free DNA, which increases rapidly after cell death, is a novel biomarker for the prognosis of critical ill patients.
Huang, Chien-Hua;Tsai, Min-Shan;Hsu, Chiung-Yuan;Chen, Huei-Wen;Wang, Tzung-Dau;Chang, Wei-Tien;Ma, Matthew Huei-Ming;Chien, Kuo-Liong;Chen, Shyr-Chyr;Chen, Wen-Jone +1 more
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DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. [PDF]
, 2002 Alkylating agents, such as methyl methanesulfonate (MMS), damage DNA and activate the DNA damage checkpoint. Although many of the checkpoint proteins that transduce damage signals have been identified and characterized, the mechanism that senses the ...
Lindsay, Howard D. +11 more
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