Results 21 to 30 of about 3,251,205 (352)

Evaluation of cell-free DNA approaches for multi-cancer early detection.

Cancer Cell, 2022
In the Circulating Cell-free Genome Atlas (NCT02889978) substudy 1, we evaluate several approaches for a circulating cell-free DNA (cfDNA)-based multi-cancer early detection (MCED) test by defining clinical limit of detection (LOD) based on circulating ...
A. Jamshidi, Minetta C. Liu, Eric A. Klein, O. Venn, E. Hubbell, J. Beausang, S. Gross, Collin Melton, Alexander P. Fields, Qinwen Liu, Na Zhang, E. Fung, K. Kurtzman, Hamed Amini, Craig M. Betts, D. Civello, Peter Freese, Robert Calef, Konstantin Davydov, Saniya Fayzullina, C. Hou, R. Jiang, B. Jung, Susan Tang, V. Demas, Joshua Newman, O. Sakarya, Eric Scott, Archana Shenoy, S. Shojaee, Kristan K. Steffen, V. Nicula, Tom C. Chien, Siddhartha Bagaria, N. Hunkapiller, Mohini Desai, Zhao Dong, D. Richards, T. Yeatman, A. Cohn, David D. Thiel, D. Berry, M. Tummala, K. McIntyre, M. Sekeres, Alan Bryce, A. Aravanis, M. Seiden, C. Swanton   +48 more
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Plasma Cell-Free DNA After Embolization

Journal of Vascular Anomalies, 2023
Objectives:. To identify genetic variants in venous malformations for noninvasive diagnosis using peripheral plasma Cell-free DNA (cfDNA) after ethanol embolization. Method:.
Yi Sun, Ren Cai, Zhenfeng Wang, Deming Wang, Xiong Zhao, Xiaojie Yue, Hao Gu, Hao Shi, Yun Liu, Xindong Fan, Lixin Su   +10 more
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Inferring gene expression from cell-free DNA fragmentation profiles

Nature Biotechnology, 2022
Profiling of circulating tumor DNA (ctDNA) in the bloodstream shows promise for noninvasive cancer detection. Chromatin fragmentation features have previously been explored to infer gene expression profiles from cell-free DNA (cfDNA), but current ...
M. S. Esfahani, Emily G. Hamilton, Mahya Mehrmohamadi, B. Nabet, S. Alig, D. King, C. Steen, C. Macaulay, A. Schultz, Monica C. Nesselbush, Joanne Soo, J. Schroers-Martin, Binbin Chen, M. Binkley, H. Stehr, J. Chabon, B. Sworder, A. Hui, M. Frank, E. Moding, C. Liu, Aaron M. Newman, J. Isbell, C. Rudin, Bob T. Li, D. Kurtz, M. Diehn, A. Alizadeh   +27 more
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Multi-faceted attributes of salivary cell-free DNA as liquid biopsy biomarkers for gastric cancer detection

Biomarker Research, 2023
Background Recent advances in circulating cell-free DNA (cfDNA) analysis from biofluids have opened new avenues for liquid biopsy (LB). However, current cfDNA LB assays are limited by the availability of existing information on established genotypes ...
Neeti Swarup, Jordan Cheng, Irene Choi, You Jeong Heo, Misagh Kordi, Mohammad Aziz, Akanksha Arora, Feng Li, David Chia, Fang Wei, David Elashoff, Liying Zhang, Sung Kim, Yong Kim, David T.W. Wong   +14 more
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Influence of preanalytical variables on the quality of cell-free DNA. Biobanking of cell-free DNA material

Кардиоваскулярная терапия и профилактика, 2022
The search for early disease markers and the development of diagnostic systems has recently been expanding within genomics. Genomic deoxyribonucleic acid (DNA), cell-free DNA (cfDNA) and microbiome DNA obtained from different types of samples (tissues ...
V. A. Kondratskaya, M. S. Pokrovskaya, Yu. V. Doludin, A. L. Borisova, A. S. Limonova, А. N. Meshkov, O. M. Drapkina   +6 more
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Detection and characterization of lung cancer using cell-free DNA fragmentomes

Nature Communications, 2021
Non-invasive approaches for cell-free DNA (cfDNA) assessment provide an opportunity for cancer detection and intervention. Here, we use a machine learning model for detecting tumor-derived cfDNA through genome-wide analyses of cfDNA fragmentation in a ...
D. Mathios, J. S. Johansen, S. Cristiano, J. Medina, J. Phallen, K. Larsen, D. Bruhm, N. Niknafs, Leonardo Ferreira, V. Adleff, J. Chiao, A. Leal, Michael Noe, J. White, Adith S. Arun, C. Hruban, A. Annapragada, S. Jensen, M. W. Ørntoft, A. H. Madsen, B. Carvalho, M. de Wit, J. Carey, N. Dracopoli, T. Maddala, K. Fang, A. Hartman, P. Forde, V. Anagnostou, J. Brahmer, R. Fijneman, H. Nielsen, G. Meijer, C. Andersen, A. Mellemgaard, S. Bojesen, Robert B. Scharpf, V. Velculescu   +37 more
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The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review

Frontiers in Oncology, 2018
BackgroundCell-free DNA (cfDNA) can be detected in the circulation of healthy individuals, but is found in higher concentrations in cancer patients. Furthermore, mutations in tumor cells can be identified in circulating DNA fragments.
Jonathan M. Fussey, Jennifer L. Bryant, Nikolaos Batis, Rachael J. Spruce, Andrew Hartley, James S. Good, Christopher J. McCabe, Kristien Boelaert, Neil Sharma, Hisham Mehanna   +9 more
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Genome-wide cell-free DNA fragmentation in patients with cancer

Nature, 2019
Cell-free DNA in the blood provides a non-invasive diagnostic avenue for patients with cancer1. However, characteristics of the origins and molecular features of cell-free DNA are poorly understood. Here we developed an approach to evaluate fragmentation
S. Cristiano, A. Leal, J. Phallen, J. Fiksel, V. Adleff, D. Bruhm, S. Jensen, J. Medina, C. Hruban, J. White, Doreen Palsgrove, N. Niknafs, V. Anagnostou, P. Forde, J. Naidoo, Kristen A Marrone, J. Brahmer, Brian D. Woodward, H. Husain, K. V. van Rooijen, M. W. Ørntoft, A. H. Madsen, C. J. van de Velde, M. Verheij, A. Cats, C. Punt, G. Vink, N. V. van Grieken, M. Koopman, R. Fijneman, J. Johansen, H. Nielsen, G. Meijer, C. Andersen, Robert B. Scharpf, V. Velculescu   +35 more
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Cell-free (RNA) and cell-associated (DNA) HIV-1 and postnatal transmission through breastfeeding [PDF]

, 2012
<p>Introduction - Transmission through breastfeeding remains important for mother-to-child transmission (MTCT) in resource-limited settings. We quantify the relationship between cell-free (RNA) and cell-associated (DNA) shedding of HIV-1 virus in ...
Van de Perre, P, James Ndirangu, Ndirangu James, Ruth M. Bland, Van de Perre Philippe, Ruth M Bland, Thorne, C., Danaviah, S, Thorne Claire, Newell Marie-Louise, Newell, M.-L., Viljoen, J., Ndirangu, J., Newell, M-L, Thorne, C, Van de Perre, P., Danaviah Siva, Bland, R.M., Philippe Van de Perre, Viljoen, J, Marie-Louise Newell, Ndirangu, J, Claire Thorne, Bland, RM, Danaviah, S., Siva Danaviah, Viljoen Johannes, Bland Ruth M., Johannes Viljoen   +28 more
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Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers

Cells, 2019
As the majority of cancers and gestational diseases are prognostically stage- and grade-dependent, the ultimate goal of ongoing studies in precision medicine is to provide early and timely diagnosis of such disorders.
Valentina Karin-Kujundzic, Ida Marija Sola, Nina Predavec, Anamarija Potkonjak, Ema Somen, Pavao Mioc, Alan Serman, Semir Vranic, Ljiljana Serman   +8 more
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