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Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders [PDF]
Advanced ScienceInflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs. Cell‐free DNA (cfDNA) is not only a biomarker for various inflammatory diseases, but also a driver in innate immune responses, offering ...
Jiatong Li +7 more
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Immunoregulatory properties of cell free DNA [PDF]
Cellular and Molecular Life SciencesCell free DNA (cfDNA) is detectable at low concentrations in the plasma of healthy subjects and at high concentrations in disorders characterized by a high rate of necrotic events, such as tumors and vasculitis, leading to the release of necrotic DNA ...
Francesca Ferrera +20 more
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Phenotypes from cell-free DNA [PDF]
Open Biology, 2020 Cell-free DNA (cfDNA) has the potential to enable non-invasive detection of disease states and progression. Beyond its sequence, cfDNA also represents the nucleosomal landscape of cell(s)-of-origin and captures the dynamics of the epigenome.
Alexis Zukowski +2 more
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Cell-free fetal DNA and cell-free total DNA levels in spontaneous abortion with fetal chromosomal aneuploidy. [PDF]
PLoS ONE, 2013 Cell-free fetal DNA and cell-free total DNA in maternal circulation have been proposed as potential markers for noninvasive monitoring of the placental condition during the pregnancy. However, the correlation of and change in cell-free fetal DNA and cell-
Ji Hyae Lim +7 more
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Isolation and Quantification of Plasma Cell-Free DNA Using Different Manual and Automated Methods
Diagnostics, 2022 Plasma cell-free DNA (cfDNA) originates from various tissues and cell types and can enable minimally invasive diagnosis, treatment and monitoring of cancer and other diseases.
Eleni Polatoglou +4 more
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Plasma contains ultrashort single-stranded DNA in addition to nucleosomal cell-free DNA
iScience, 2022 Summary: Plasma cell-free DNA is being widely explored as a biomarker for clinical screening. Currently, methods are optimized for the extraction and detection of double-stranded mononucleosomal cell-free DNA of ∼160bp in length. We introduce uscfDNA-seq,
Jordan Cheng +13 more
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Plasma Cell-Free DNA After Embolization
Journal of Vascular Anomalies, 2023 Objectives:. To identify genetic variants in venous malformations for noninvasive diagnosis using peripheral plasma Cell-free DNA (cfDNA) after ethanol embolization. Method:.
Yi Sun +10 more
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Biomarker Research, 2023 Background Recent advances in circulating cell-free DNA (cfDNA) analysis from biofluids have opened new avenues for liquid biopsy (LB). However, current cfDNA LB assays are limited by the availability of existing information on established genotypes ...
Neeti Swarup +14 more
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Кардиоваскулярная терапия и профилактика, 2022 The search for early disease markers and the development of diagnostic systems has recently been expanding within genomics. Genomic deoxyribonucleic acid (DNA), cell-free DNA (cfDNA) and microbiome DNA obtained from different types of samples (tissues ...
V. A. Kondratskaya +6 more
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Frontiers in Oncology, 2018 BackgroundCell-free DNA (cfDNA) can be detected in the circulation of healthy individuals, but is found in higher concentrations in cancer patients. Furthermore, mutations in tumor cells can be identified in circulating DNA fragments.
Jonathan M. Fussey +9 more
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