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Active Site of Deoxyribonuclease I: I. The Nature of Active Site of Deoxyribonuclease I
Radiation Research, 1961Ionizing radiation and specific inhibitors for amino acid residues were used to demonstrate which amino acid residues are involved in the active site of the enzyme deoxyribonuclease I. Bromoacetic acid, lodoacetic acid, diisopropylfluorophosphate, p-chloromercuribenozate, tryptophan, histidine, cinnamic alcohol, cinnamaldehyde, indole, arginine, and ...
S, OKADA, G L, FLETCHER
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Development of a radioimmunoassay for human deoxyribonuclease I
Clinica Chimica Acta, 1986A reliable radioimmunoassay (RIA) for human deoxyribonuclease I (DNase I) is described. Using delayed addition of tracer antigen, the method is sensitive (9.5 reproducible and specific. A good parallel relationship was observed between the standard curve and dilution curves for human urine and human pancreatic juice.
Keisuke Miyauchi +2 more
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Comparative biochemical properties of vertebrate deoxyribonuclease I
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2012Deoxyribonuclease I (DNase I, EC 3.1.21.1) is an endonuclease that preferentially attacks double-stranded DNA in a Ca(2+)-dependent manner to produce oligonucleotides with 5'-phospho and 3'-hydroxy termini. This review deals with the biochemical properties and molecular evolution of DNase I. A comparative study of vertebrate DNase I from Chondrichthyes
Junkô Fujihara +2 more
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Depolymerization of F-actin by deoxyribonuclease I
Cell, 1976Deoxyribonuclease I causes depolymerization of filamentous muscle actin to form a stable complex of 1 mole DNAase I:1 mole actin. The regulatory proteins tropomyosin and troponin bind to filamentous actin and slow down but do not prevent the depolymerization. In the absense of ATP, heavy meromyosin binds tightly to actin filaments and blocks completely
S E, Hitchcock, L, Carisson, U, Lindberg
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Benzimidazoles as novel deoxyribonuclease I inhibitors
Journal of Cellular Biochemistry, 2018AbstractInhibitory potential of 19 benzimidazoles against bovine pancreatic deoxyribonuclease I (DNase I) was investigated in vitro. Three compounds inhibited DNase I with IC50 below 100 μM and proved to be more potent DNase I inhibitors than crystal violet (IC50 = 351.82 ± 29.41 μM), used as a positive control.
Ana Kolarević +6 more
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Periodicity of Deoxyribonuclease I Digestion of Chromatin
Science, 1979Two methods have been used to measure the single-strand lengths of the DNA fragments produced by deoxyribonuclease I digestion of chromatin. The average lengths obtained are multiples of about 10.4 bases, significantly different from the value of 10 previously reported.
A, Prunell +5 more
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