Results 1 to 10 of about 191,069 (135)
Elucidating the functional dynamics of DNASE1L2 intron retention in tuberculosis progression [PDF]
Chinese Medical Journal. Background:. Intron retention (IR) is an important biological process associated with disease development. However, the role of IR in the progression of tuberculosis (TB) remains unexplored.
Mengyuan Lyu +15 more
doaj +2 more sources
A tissue-penetrably engineered deoxyribonuclease 1 to prevent nasal polyp formation in chronic rhinosinusitis [PDF]
BMC Pharmacology and ToxicologyBackground Neutrophilic chronic rhinosinusitis (CRS) is characterized by persistent inflammation and often responds poorly to corticosteroid therapy. In this disease, neutrophil extracellular traps (NETs) are increasingly recognized as key mediators of ...
Su-Bin Kwak +4 more
doaj +2 more sources
Gene therapy enhances deoxyribonuclease I treatment in antimyeloperoxidase glomerulonephritis [PDF]
JCI InsightExtracellular DNA (ecDNA) released from injured and dying cells powerfully induces injurious inflammation. In this study we define the role of ecDNA in systemic vasculitis affecting the kidney, using human kidney biopsies and murine models of ...
Anne Cao Le +13 more
doaj +2 more sources
Frontiers in Molecular Biosciences, 2022 The genome of pathogenic Leptospira interrogans serovars (Copenhageni and Lai) are predicted to have CRISPR-Cas of subtypes I-B and I-C. Cas2, one of the core Cas proteins, has a crucial role in adaptive defense against foreign nucleic acids.
Vineet Anand +4 more
doaj +1 more source
Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy
Frontiers in Immunology, 2023 Deep venous thrombosis (DVT) is a part of venous thromboembolism (VTE) that clinically manifests as swelling and pain in the lower limbs. The most serious clinical complication of DVT is pulmonary embolism (PE), which has a high mortality rate.
Mengting Yao +11 more
doaj +1 more source
Cell-Free Double-Stranded DNA to DNase Ratio Predicts Outcome after Primary Survived Cardiac Arrest
Cells, 2022 (1) Double-stranded DNA (dsDNA) and deoxyribonuclease (DNase) as surrogate parameters for accumulating inflammatory hazards are insufficiently studied in resuscitation research. (2) Blood samples of 76 individuals after CA were analyzed 24 and 96 h after
Richard Rezar +13 more
doaj +1 more source
Evaluation of HiaureusTM Coagulase Confirmation Kit in Identification of Staphylococcus aureus [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: Staphylococcus aureus is a facultative anaerobic Gram positive coccal bacterium whose incidence ranges to different infections. It is a cause of various uncomplicated skin infections, abscesses, septicaemia/bacteraemia, gastroenteritis,
Arunagiri Subramanian +6 more
doaj +1 more source
New therapy of pleural empyema by deoxyribonuclease
Brazilian Journal of Infectious Diseases, 2013 Empyema is a severe complication of different diseases and traumas. Management of this complication is difficult and should comprise general and local procedures. The general procedure is mainly based on administering wide-spectrum antibiotics.
Grzegorz Kacprzak +5 more
doaj +5 more sources
Pharmaceutics, 2021 Biofilms of Cutibacterium (C.) acnes (formerly Propionibacterium acnes) are responsible for the persistence and antibiotic resistance of acne vulgaris. In addition to the standard treatments for acne vulgaris, a common adjunctive treatment is the topical
Yi-Hsien Shih +5 more
doaj +1 more source
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks
eLife, 2020 Type V CRISPR-Cas interference proteins use a single RuvC active site to make RNA-guided breaks in double-stranded DNA substrates, an activity essential for both bacterial immunity and genome editing.
Joshua C Cofsky +5 more
doaj +1 more source