Results 41 to 50 of about 192,494 (228)

2-Nitro-5-Thiosulfobenzoic Acid as a Novel Inhibitor Specific for Deoxyribonuclease I

, 2009
Bovine pancreatic deoxyribonuclease I (bpDNase I) contains four cysteine residues forming two disulfide bonds. Though there are no free sulfhydryl groups, incubation of bpDNase I with 2-nitro-5-thiosulfobenzoic acid (NTSB ) in the presence of Ca(2+)or ...
陳威戎;廖大修, CHEN, WEI-JUNG;LIAO, TA-HSIU;CHEN, WEI -JUNG   +1 more
core   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Deoxyribonuclease partially ameliorates thioacetamide-induced hepatorenal injury

, 2017
Several recent studies have shown that liver injury is associated with the release of DNA from hepatocytes. This DNA stimulates innate immunity and induces sterile inflammation, exacerbating liver damage.
Veronika Melišková, Jozef Čonka, Lenka Vokálová, Janka Bábíčková, Veronika Borbélyová, Lucia Lauková, Barbora Vlková, Július Hodosy, L’ubomíra Tóthová, Peter Celec   +9 more
core   +1 more source

Cell Death by Holocrine Secretion: The Final Step of Epithelial Differentiation in Sebaceous Glands

Cells
Sebaceous glands consist of epithelial cells, known as sebocytes, that undergo differentiation to deliver the components of sebum into the sebaceous duct and eventually to the hair and skin surface.
Leopold Eckhart, Supawadee Sukseree, Heinz Fischer   +2 more
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Different deoxyribonucleases in human lymphocytes [PDF]

Nucleic Acids Research, 1974
The distribution pattern of deoxyribonuclease activities in human lymphocytes has been examined by micro-disc-electrophoresis. Four groups of deoxyribonuclease activities, differing in their electrophoretic mobility, in the nature of their optimal substrate and in their optimal incubation conditions, are characterized.
E J, Zöllner, W, Helm, R K, Zahn, J, Beck, M, Reitz   +4 more
openaire   +2 more sources

Ion-dependency of the streptococcal deoxyribonuclease “streptodornase”, an active constituent of the medicament Varidase®

, 2002
The activity of streptodornase, a deoxyribonuclease active protein component of the medicament Varidase® has been shown to be dependant on the presence and concentration of certain cation species.
Locke, I., Carpenter, Brian, Carpenter, B.G., Locke, I.C.   +3 more
core   +1 more source

Assessment of Deoxyribonuclease Activity in Biological Samples by a Fluorescence Detection-Based Method [PDF]

, 2013
Objective: To develop a speedy, sensitive, low-cost fluorescence detection assay for assessing deoxyribonuclease activity in biological samples. Methods: Deoxyribonuclease activity was measured in serum samples of 15 patients with lung cancer and 15 ...
Vancevska, Aleksandra, Nikolić, Aleksandra   +1 more
core   +1 more source

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source

Studies on the Neutral Deoxyribonuclease Activity in Highly Purified Acid Deoxyribonuclease

Journal of Biological Chemistry, 1972
Abstract The presence of neutral deoxyribonuclease activity in highly purified preparation of acid deoxyribonuclease from sheep spleen (deoxyribonuclease II, EC 3.1.4.6) is described. The activity at pH 7.0 differs from the activity at pH 4.5 in its optimal ionic strength, its inhibition by tRNA, inhibition by EDTA, and activation by divalent cations ...
H, Slor, T, Lev
openaire   +2 more sources